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Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

technology.org

21–30 of 128 posts

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#21
post #3

Okay this sounds great, what is the specific protocol they talk about in the article, is it some breathing techniques in the chamber or four one hour sessions per day for 5 years?

60 sessions, 90 minutes, 100% oxygen via mask with breaks every 20 minutes, over 3 months, 5 per week. Seems like this is a great thing, hopefully it pans out over larger populations of patients.

100% oxygen under high pressure is dangerous

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#23
post #4

Here’s the paper https://www.aging-us.com/article/203485 > The study population comprised adults (5 males, 1 female) with significant memory decline aged 64 years and older > The protocol consisted of 60 daily sessions at 5 sessions per week within a three-month period. Each session included breathing 100% oxygen by mask at 2ATA for 90 min with 5 min air breaks every 20 min. > At baseline, patients attained a mean gl…

Here is what WP says about this journal: https://en.wikipedia.org/wiki/Aging_(journal)

Since it's not immediately obvious what the issue is since it's in the "reception" section

> The peer review process employed by the journal has been criticized by Jeffrey Beall, a university librarian and expert on predatory open access publishing, who also included the journal and its publisher on his list of "potential, possible, or probable predatory scholarly open-access journals" in July 2015.

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#24
post #10

Anyone interested in this should also take a look at Lions Mane Mushrooms. They have been shown to significantly help with cognitive decline.

Citation needed; I know research into psychedelics is difficult due to restrictions, but anecdotal evidence is not enough to start recommending it without listing the necessary caveats. I mean "Ivermectin has been shown to significantly help with Covid" has the same weight to it, and I'd never recommend anyone take horse dewormer. Maybe if they had worms and it was the only thing available.

> research into psychedelics is difficult due to restrictions, but anecdotal evidence is not enough to start recommending it

Eh? Lions Mane doesn't have any psychedelic or psychoactive effects.

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#25
post #10

Anyone interested in this should also take a look at Lions Mane Mushrooms. They have been shown to significantly help with cognitive decline.

Citation needed; I know research into psychedelics is difficult due to restrictions, but anecdotal evidence is not enough to start recommending it without listing the necessary caveats. I mean "Ivermectin has been shown to significantly help with Covid" has the same weight to it, and I'd never recommend anyone take horse dewormer. Maybe if they had worms and it was the only thing available.

Lion's Mane mushrooms are not psychedelics though

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#26

Earlier quoted context omitted.

Citation needed; I know research into psychedelics is difficult due to restrictions, but anecdotal evidence is not enough to start recommending it without listing the necessary caveats. I mean "Ivermectin has been shown to significantly help with Covid" has the same weight to it, and I'd never recommend anyone take horse dewormer. Maybe if they had worms and it was the only thing available.

Ivermectin is an FDA approved drug and is regularly prescribed to humans. Sure, it probably doesn't do anything for covid but it's not just 'horse dewormer'.

You can remove the "probably". The manufacturer of Ivermectin states there is no scientific evidence [0] supporting the use of the drug for COVID-19. So much for the notion some espouse that "Big Pharma" pushes their drugs on us without fail.

[0] https://www.merck.com/news/merck-statement-on-ivermectin-use...

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#27
post #11
post #6

Earlier quoted context omitted.

The popular paper completely fails to to state sample size or selection. It seems 10+10 mice also were studied. Maybe a little early to call it a breakthrough...

What do you mean? The sample size was 6, and they were selected on having the same symptoms. There is more information on the statistical analysis in the paper, but the conclusion is that it was significant. If this is a significant treatment of Alzheimer's then that's a breakthrough to me, what bar would you set?

statistical significance is not the same as clinical significance. statistical significance in a small non-placebo controlled trial is less likely to result in a clinically meaningful result.

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#28

If this turns out to be true I wonder if it'd be practical (given the financial resources) to have pressure sealed rooms that you spend a lot of time in at home (e.g. your office). These could be precisely controlled (O2, CO2 levels, pressure, …) and possibly both increase current and future performance. The main problem seems the time needed to exit because an abrupt loss of pressure would be hazardous. But if you h…

Isn't the Big Blue Room this precisely controlled environment where you're supposed to spend a lot of time in, breathing oxygen?

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#29
Thoughts that popped up:

1. Isn’t hyperbaric therapy used by athletes to reduce inflammation?

2. Isn’t the failure of the amyloid hypothesis leading to researchers considering whether inflammation is the progenitor of Alzheimer’s?

So if hyperbaric therapy does work… could that be a sign in favor of the inflammation hypothesis? Although, the authors suggest the results are due to improved oxygenation rather than any anti-inflammatory effects.

Also, I’m not a doctor nor am I educated in medical things.

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