Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

technology.org

Post reply on HN
Print view View original

11–20 of 128 posts

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#11

Post by tinco »

nxpnsv wrote: post #6
ed wrote: post #4

Here’s the paper https://www.aging-us.com/article/203485 > The study population comprised adults (5 males, 1 female) with significant memory decline aged 64 years and older > The protocol consisted of 60 daily sessions at 5 sessions per week within a three-month period. Each session included breathing 100% oxygen by mask at 2ATA for 90 min with 5 min air breaks every 20 min. > At baseline, patients attained a mean gl…

The popular paper completely fails to to state sample size or selection. It seems 10+10 mice also were studied. Maybe a little early to call it a breakthrough...

What do you mean? The sample size was 6, and they were selected on having the same symptoms. There is more information on the statistical analysis in the paper, but the conclusion is that it was significant.

If this is a significant treatment of Alzheimer's then that's a breakthrough to me, what bar would you set?

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#12

Post by [deleted] »

nxpnsv wrote: post #6
ed wrote: post #4

Here’s the paper https://www.aging-us.com/article/203485 > The study population comprised adults (5 males, 1 female) with significant memory decline aged 64 years and older > The protocol consisted of 60 daily sessions at 5 sessions per week within a three-month period. Each session included breathing 100% oxygen by mask at 2ATA for 90 min with 5 min air breaks every 20 min. > At baseline, patients attained a mean gl…

The popular paper completely fails to to state sample size or selection. It seems 10+10 mice also were studied. Maybe a little early to call it a breakthrough...

[deleted]

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#13

Post by [deleted] »

tinco wrote: post #11
nxpnsv wrote: post #6

Earlier quoted context omitted.

The popular paper completely fails to to state sample size or selection. It seems 10+10 mice also were studied. Maybe a little early to call it a breakthrough...

What do you mean? The sample size was 6, and they were selected on having the same symptoms. There is more information on the statistical analysis in the paper, but the conclusion is that it was significant. If this is a significant treatment of Alzheimer's then that's a breakthrough to me, what bar would you set?

[deleted]

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#15

Post by JPLeRouzic »

ed wrote: post #4

Here’s the paper https://www.aging-us.com/article/203485 > The study population comprised adults (5 males, 1 female) with significant memory decline aged 64 years and older > The protocol consisted of 60 daily sessions at 5 sessions per week within a three-month period. Each session included breathing 100% oxygen by mask at 2ATA for 90 min with 5 min air breaks every 20 min. > At baseline, patients attained a mean gl…

Here is what WP says about this journal:

https://en.wikipedia.org/wiki/Aging_(journal)

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#16

Post by Cthulhu_ »

35mm wrote: post #10

Anyone interested in this should also take a look at Lions Mane Mushrooms. They have been shown to significantly help with cognitive decline.

Citation needed; I know research into psychedelics is difficult due to restrictions, but anecdotal evidence is not enough to start recommending it without listing the necessary caveats.

I mean "Ivermectin has been shown to significantly help with Covid" has the same weight to it, and I'd never recommend anyone take horse dewormer. Maybe if they had worms and it was the only thing available.

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#17

Post by robbedpeter »

andy_ppp wrote: post #3

Okay this sounds great, what is the specific protocol they talk about in the article, is it some breathing techniques in the chamber or four one hour sessions per day for 5 years?

60 sessions, 90 minutes, 100% oxygen via mask with breaks every 20 minutes, over 3 months, 5 per week.

Seems like this is a great thing, hopefully it pans out over larger populations of patients.

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#18

Post by sgeisler »

If this turns out to be true I wonder if it'd be practical (given the financial resources) to have pressure sealed rooms that you spend a lot of time in at home (e.g. your office). These could be precisely controlled (O2, CO2 levels, pressure, …) and possibly both increase current and future performance. The main problem seems the time needed to exit because an abrupt loss of pressure would be hazardous. But if you have a well-structured day it might work. This could be very interesting for high earning knowledge workers imo.

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#19

Post by R0b0t1 »

sgeisler wrote: post #18

If this turns out to be true I wonder if it'd be practical (given the financial resources) to have pressure sealed rooms that you spend a lot of time in at home (e.g. your office). These could be precisely controlled (O2, CO2 levels, pressure, …) and possibly both increase current and future performance. The main problem seems the time needed to exit because an abrupt loss of pressure would be hazardous. But if you h…

If true this is even bigger, as it indicates new directions to look for cures. No longer stuck on plaques; it may be metabolic, respiratory, or pulmonary. This could be more direct evidence of it.

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#20

Post by vncecartersknee »

Cthulhu_ wrote: post #16
35mm wrote: post #10

Anyone interested in this should also take a look at Lions Mane Mushrooms. They have been shown to significantly help with cognitive decline.

Citation needed; I know research into psychedelics is difficult due to restrictions, but anecdotal evidence is not enough to start recommending it without listing the necessary caveats. I mean "Ivermectin has been shown to significantly help with Covid" has the same weight to it, and I'd never recommend anyone take horse dewormer. Maybe if they had worms and it was the only thing available.

Ivermectin is an FDA approved drug and is regularly prescribed to humans. Sure, it probably doesn't do anything for covid but it's not just 'horse dewormer'.
Post reply on HN