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Cannabis use and myocardial infarction in young adults: a cross-sectional study

cmaj.ca

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Re: Cannabis use and myocardial infarction in young adults: a cross-sectional study

#11

Post by LegitShady »

arpinum wrote: post #3

I appreciate the study calls out that most cannabis is smoked, and it may be general smoke inhalation driving these results rather than an inherent property of cannabis

It doesn't say that at all.

>The effect estimates for history of MI were similar across methods of consumption, including among people using other forms of cannabis, including edibles, as a primary method of consumption. This finding is consistent with a case study reporting an acute MI triggered after consumption of a lollipop containing a large dose of Δ-9-tetrahydrocannabinol.36 The Canadian government recently legalized cannabis edibles;2 however, the risks associated with edibles are poorly understood and are of concern to Canadian physicians.37 Edibles are often perceived as a safer alternative for cannabis consumption, but recent evidence suggests that edible cannabis is attributed to a larger proportion of cannabis-related emergency department visits for cardiovascular symptoms compared with inhaled cannabis

Re: Cannabis use and myocardial infarction in young adults: a cross-sectional study

#12

Post by eurasiantiger »

arpinum wrote: post #3

I appreciate the study calls out that most cannabis is smoked, and it may be general smoke inhalation driving these results rather than an inherent property of cannabis

It very likely is due to smoke inhalation or even mixing with tobacco; IIRC inhalation of any kind of micro- and nanoparticles is linked to higher risk of myocardial infarction.

Re: Cannabis use and myocardial infarction in young adults: a cross-sectional study

#13

Post by crazy_horse »

arpinum wrote: post #3

I appreciate the study calls out that most cannabis is smoked, and it may be general smoke inhalation driving these results rather than an inherent property of cannabis

> Smoking cannabis was the most prevalent primary method of consumption (76.3%, 95% CI 74.3%–78.4%) relative to vapourization (11.3%, 95% CI 9.8%–12.8%) and other forms of consumption, including edibles (12.4%, 95% CI 10.8%–13.9%).

> Compared with nonusers, the prevalence of recent cannabis use was higher among males (62.9% v. 49.3%), unmarried respondents (68.0% v. 46.4%), current combustible cigarette users (31.6% v. 13.2%), current e-cigarette users (18.1% v. 5.1%) and heavy alcohol drinkers (17.4% v. 5.2%).

You run into cannabis users that have massively high tolerances because they dab all day. I wonder how d8, d10, etc would come out, cause that's probably a big part of the future, that an other cannaboid mixes.

Re: Cannabis use and myocardial infarction in young adults: a cross-sectional study

#17

Post by hirundo »

52-6F-62 wrote: post #7

This strikes me as a bit weak, and an answer looking for a question. > the current evidence is limited to case–control studies that are prone to bias and studies relying solely on administrative data.9–14 It is also limited in its definition of exposure, as these studies assess patients with heavy cannabis use (cannabis abuse or cannabis use disorder).9–14 Very few studies have assessed the prevalence of recent canna…

There is no control because there was no experiment. There is no independent variable that was controlled. This is epidemiology, not a trial. At best it can show a link, not causation.

Re: Cannabis use and myocardial infarction in young adults: a cross-sectional study

#18

Post by zerobits »

It’s strange that all of the comments are looking for ways to dismiss this result (and this seems to happen generally with negative cannabis findings online).

Is it not entirely possible a drug and method of consumption which stresses the cardiovascular system increases odds of an adverse cardiovascular event?

Re: Cannabis use and myocardial infarction in young adults: a cross-sectional study

#19

Post by oxymoran »

LegitShady wrote: post #11
arpinum wrote: post #3

I appreciate the study calls out that most cannabis is smoked, and it may be general smoke inhalation driving these results rather than an inherent property of cannabis

It doesn't say that at all. >The effect estimates for history of MI were similar across methods of consumption, including among people using other forms of cannabis, including edibles, as a primary method of consumption. This finding is consistent with a case study reporting an acute MI triggered after consumption of a lollipop containing a large dose of Δ-9-tetrahydrocannabinol.36 The Canadian government recently le…

“Although a similarly elevated odds of history of MI was observed across methods of recent cannabis consumption, only smoking as a primary method achieved statistical significance.“
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