Tangentially related question: could Nuitka target WebAssembly, given that according to their overview page, they translate Python into C? Usually when it comes to Python -> WebAssembly, the biggest problem is the lack of GC in the WebAssembly spec (as far as I understand), and I'm wondering if this would be an issue for Nuitka as well...
See :
https://github.com/pyodide/pyodide
And an example featuring a pure client side jupyter instance :