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Immunity Generated from Covid-19 Vaccines Differs from an Infection

directorsblog.nih.gov

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Re: Immunity Generated from Covid-19 Vaccines Differs from an Infection

#2
It would be interesting to see the duration of the immunity or resistance across multiple vaccine variants. The latest data from the UK indicates that the AZ vaccine suffers less degradation over time than Pfizer, at least when it comes to the Delta variant which is now the prevalent one in the UK.

Israel has now giving boosters to 30 year olds and older in order to boost the immunity to infection and resistance to severe illness.

Re: Immunity Generated from Covid-19 Vaccines Differs from an Infection

#3
The spike protein targeting antibodies produced by the vaccine do indeed target a wider range of spike mutations than the spike protein antibodies from previous infection. However, vaccines only target spike protein, while a previous infection will cause your body to produce antibodies for a much larger set of targets on the virus, which in practice leads to a more robust immunity. This is supported by data from Israel and some recent studies.

https://www.israelnationalnews.com/News/News.aspx/309762

https://www.israelnationalnews.com/News/News.aspx/310963

https://www.medrxiv.org/content/10.1101/2021.08.24.21262415v...

Re: Immunity Generated from Covid-19 Vaccines Differs from an Infection

#7
> antibodies elicited by the mRNA vaccine were more focused to the RBD compared to antibodies elicited by an infection, which more often targeted other portions of the spike protein.

I wonder how this might impact the design of future mRNA vaccines. For example, could vaccines target multiple proteins that both are associated with the virus?

Re: Immunity Generated from Covid-19 Vaccines Differs from an Infection

#8

It would be interesting to see the duration of the immunity or resistance across multiple vaccine variants. The latest data from the UK indicates that the AZ vaccine suffers less degradation over time than Pfizer, at least when it comes to the Delta variant which is now the prevalent one in the UK. Israel has now giving boosters to 30 year olds and older in order to boost the immunity to infection and resistance to s…

My understanding is that it may be due to the difference of time during the two shots. It's possible that 2 weeks between the two shots of Pfizer is too short. We're learning.

Re: Immunity Generated from Covid-19 Vaccines Differs from an Infection

#9
Antigen targets aside, there is also a difference in the production of antibodies in the mucosal system.

Current vaccines are intra muscular and lacks a robust mucosal response while natural infection will provide mucosal immunity as well.

As one can imagine, mucosal immunity is very important in an upper respiratory track disease w.r.t. symptomatic infection and transmission.

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