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Launch HN: Fella (YC W20) – Tackling men's obesity using medication and coaching

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141–150 of 318 posts

Re: Launch HN: Fella (YC W20) – Tackling men's obesity using medication and coaching

#141

Earlier quoted context omitted.

I’m aware about it in theory, but I think for people already in us on a work visa it’s a chicken and egg problem between starting and getting the o1. I can’t start anything as I can only work for my employer, and I can’t get an o1 because I can’t start anything. Looks like the founders are not interested in answering this one.

We're actually not based in the US right now as we had to return home for covid, and we're building a remote co. To be honest we sadly don't have any useful advice for US visas: it's not a fun system. Only thing is it's now more possible than ever to soak up US culture, run a US-focused company, but not be based in the US. But that's not what you wanna hear if you've built your life there. I'm sorry we can't be more…

Thanks for answering! I guess it’s true remote work is taking over, good luck with everything!

Re: Launch HN: Fella (YC W20) – Tackling men's obesity using medication and coaching

#142

Earlier quoted context omitted.

Spot on about fasting, and keto has solid evidence as well - https://www.virtahealth.com/ are a great company focused on this. The issue is we're starting to have a more nuanced understanding of the metabolic resistance people face when they undergo dietary changes - basically the body fights hard against you as you try to lose weight by dieting. So it's now industry-standard among obesity specialist doctors to see o…

> basically the body fights hard against you as you try to lose weight by dieting. I used to weigh 310lbs, now I'm 215lbs. All I did was count calories to maintain a deficit and the results were essentially the same as predicted by the math. I was a bit hungry sometimes at first as I adjusted to it but that's really it. Prioritizing protein and fat over carbs helps with that. What ways does the body tend to fight aga…

Extreme hunger, like others said. I'd class it as a subset of impulsive behavior, which is basically your primitive brain doing it's caveman shit and not listening to you, the conscious mind.

Apparently some people don't have this problem, which makes me incredibly envious (or would if I could feel anything).

It's this nagging thought of "JESUS CHRIST YOU'RE GONNA DIE IF YOU DON'T EAT A LOT RIGHT NOW!"

I've experienced it after hard days at work (construction), multi hour lifting, cycling 50km. Same shit every time. Surprisingly, unlike what my dumbass brain says, I don't die if I eat only a little and just go to sleep.

Counting calories didn't work btw. It actually made it worse as my primitive brain would know it's "starving".

Re: Launch HN: Fella (YC W20) – Tackling men's obesity using medication and coaching

#143

Earlier quoted context omitted.

Spot on about fasting, and keto has solid evidence as well - https://www.virtahealth.com/ are a great company focused on this. The issue is we're starting to have a more nuanced understanding of the metabolic resistance people face when they undergo dietary changes - basically the body fights hard against you as you try to lose weight by dieting. So it's now industry-standard among obesity specialist doctors to see o…

> basically the body fights hard against you as you try to lose weight by dieting. I used to weigh 310lbs, now I'm 215lbs. All I did was count calories to maintain a deficit and the results were essentially the same as predicted by the math. I was a bit hungry sometimes at first as I adjusted to it but that's really it. Prioritizing protein and fat over carbs helps with that. What ways does the body tend to fight aga…

I used to be able to do that in my twenties. Now, in my thirties, it appears I have lost that ability. Cutting my calories seems to causey body to go into a sort of hibernation where it becomes more efficient and conserves more calories.

In other words, my metabolic burn rate at rest and while active seems to go down significantly.

Re: Launch HN: Fella (YC W20) – Tackling men's obesity using medication and coaching

#144
post #65

[flagged]

Of course obesity is an emotional topic but attacking someone personally about it is way, way beyond the pale. Breaking the HN guidelines will get you banned here, regardless of how right you are, or feel you are, about obesity and other topics. No more of this, please. https://news.ycombinator.com/newsguidelines.html

[flagged]

Re: Launch HN: Fella (YC W20) – Tackling men's obesity using medication and coaching

#145

How is the drug different than victoza or any of the other weight management drugs that are currently under investigation for causing pancreatic cancer?

(Richie's co-founder here)

Victoza is the brand name for Liraglutide. The drug we are primarily interested in is Semaglutide. Both Semaglutide and Liraglutide are GLP-1 receptor agonists.

It's worth doing your own research and consulting a doctor but the experts I've spoken to (academics and clinicians) along with the studies state that: "GLP-1 analogues did not increase the risk for pancreatic cancer when compared to other treatments" (from a Nature Scientific Reports meta-analysis paper published in 2019) [1].

Here is the postmarket FDA safety information on Victoza if you are interested: https://www.fda.gov/drugs/postmarket-drug-safety-information...

[1] https://www.nature.com/articles/s41598-019-38956-2

Re: Launch HN: Fella (YC W20) – Tackling men's obesity using medication and coaching

#146
I don't know how young you are. Great story, but, sorry, no. Every single weight loss program claims exactly what you claim. And they all deliver pretty much exactly the same results. My guess is that about 10 to 20 percent of weight loss program participants achieve sustainable life-long objectives, keep the weight off and change their lifestyle. The rest are in a range between utter failure and yo-yo diet programs to some short term success, no long term behavioral modification and ultimately, a return to their prior state or worse.

Every single bullet point you list requires one thing that you cannot control --nobody can: A personal decision to change. And no pill is going to force this decision.

Look, maybe you are well-meaning, however, what you are looking to do here is no different from the myriad weight loss supplements out there. I know people who made millions peddling Garcinia Cambogia, Forskolin and other weight loss supplements on Amazon. I know people who swear by the stuff. I would be willing to bet that, statistically speaking the results are not very different from almost any other purported solution.

At the end of the day, the day weight loss isn't difficult at all.

In its harshest form its as simple as eating less. Even if you eat junk, if you eat less, you lose weight. Physics.

A more sophisticated approach is to learn and decide to eat better. In both cases no exercise is required beyond normal activity.

Even a person who is confined to bedrest --no exercise at all-- will lose weight if they consume less matter than their bodies process into energy and excrete. My mother passed away a couple of months ago. A couple of months before that she simply did not want to eat very much at all. The amount of weight she lost was incredible.

The issue with obesity is bad food, unhealthy eating habits being promoted from childhood and a situation where adults almost can't escape all the things that make them sick.

And yet, after all of that, it becomes a matter of making a decision. And it is a very difficult decision to make for most. To use an analogy, it takes far more effort to help someone who becomes a drug addict than to guide them down the right path from early childhood. That also happens to be far better for society.

To use a business parallel: You can build the best hotel, have the greatest and most amazing rooms, serve incredible food and have amazing customer service. And yet, you cannot force people to take a vacation.

And so, all the bullet points in your argument sound fantastic. If you go to Jenny Craig, or Weight Watchers, they pretty much claim exactly the same things. And their road to success is paved with the sorry bodies of the millions of people who thought they found magic, only to end-up exactly where they started --or worse.

The right solution isn't a pill. Its investing time, money and effort to change what we are doing about food and how we are destroying our kids health by not acting with their best interest in mind.

That said, congratulations. With YC's backing there's probably no doubt your startup will have a unicorn-scale exit. If there's one market segment were the same story can be used again and again to make billions it is the weight loss industry. So, again, congrats. Brilliant move.

Re: Launch HN: Fella (YC W20) – Tackling men's obesity using medication and coaching

#147

How is the drug different than victoza or any of the other weight management drugs that are currently under investigation for causing pancreatic cancer?

(Richie's co-founder here) Victoza is the brand name for Liraglutide. The drug we are primarily interested in is Semaglutide. Both Semaglutide and Liraglutide are GLP-1 receptor agonists. It's worth doing your own research and consulting a doctor but the experts I've spoken to (academics and clinicians) along with the studies state that: "GLP-1 analogues did not increase the risk for pancreatic cancer when compared t…

I get how when compared to other treatments for diabetes it may not increase your risk but when we are comparing with other treatments for weight management or just no treatment at all, I find it hard to believe that it doesn't significantly increase the risk for pancan. I understand it's FDA approved but so have been all other drugs in its class that are allegedly linked to pancreatic cancer.

Re: Launch HN: Fella (YC W20) – Tackling men's obesity using medication and coaching

#148
post #95

I have done just about everything over the years to lose weight. I tend to exercise a ton naturally, so it has been more about eating less than exercising more. I would say that my natural weight is slightly overweight but not obese. I've tried various brands of keto (Atkins/4 Hour Body), Weight Watchers, eating slowly, cutting out sugar and wheat, juice fasts. Everything has worked for a time, but the weight has eve…

> I've read the research on willpower being a resource that you use up, and definitely agree with it I don't enjoy subjecting you to cognitive dissonance here...but some highly cited research shows this belief may be a self fulfilling prophecy. > Study 1 found that individual differences in lay theories about willpower moderate ego-depletion effects: People who viewed the capacity for self-control as not limited did…

Maybe the beliefs come from experiences of different 'types' and the types cause the beliefs?

Re: Launch HN: Fella (YC W20) – Tackling men's obesity using medication and coaching

#149

I don't know how young you are. Great story, but, sorry, no. Every single weight loss program claims exactly what you claim. And they all deliver pretty much exactly the same results. My guess is that about 10 to 20 percent of weight loss program participants achieve sustainable life-long objectives, keep the weight off and change their lifestyle. The rest are in a range between utter failure and yo-yo diet programs…

Please stop posting these rants. Hounding someone like this after you already personally attacked them is crossing into harassment. I already asked you to stop once, and you've responded by doing more of it, not once but twice. Seriously not cool.

We detached this comment from https://news.ycombinator.com/item?id=28258175.

Re: Launch HN: Fella (YC W20) – Tackling men's obesity using medication and coaching

#150

[flagged]

Congrats on having a relatively easy time losing weight, but you're not the only person in the world, and not everyone's body works the same as yours. Your scolding of a clinically proven weight loss approach for not being what you did is solipsistic and ignorant. Your approach is, like the others, one among many that will work for some people.

> Your scolding of a clinically proven weight loss approach for not being what you did is solipsistic and ignorant.

Far from ignorant. It is an absolute fact --thermodynamics-- that no human being needs a pill to lose weight. So, stop with the holier-than-thou come-back and think.

This is no different from selling crap weight loss supplements to people. Why? Because they do not need that either. The fact that something is clinically proven means nothing. Why? Because people don't need it.

> Your approach is, like the others, one among many that will work for some people.

It isn't my approach. I only had to lose about 30 lbs. I could have done that going back to strength training, which was I was into before the pandemic hit. I decided to see if there was any merit to what my wife, the MD, was telling me.

Major "duh" moment: Of course it had merit! And of course it can work for absolutely everyone!

And, guess what, it does not cost $150 per month. No pills necessary.

The problem with obesity, particularly in the US, is systemic. Our food is unmitigated garbage and we train our kids to eat and crave this garbage from early childhood times. By the time they become young adults they are well on their way to a life of dealing with weight problems and a straight line into diabetes and other ailments.

You can't fix inflammation from food with pills, unless you want to be popping them for the rest of your life and end-up with other problems because of it.

This is going to sound weird: I am always astounded by how much I have learned by raising and training GSD's (German Shepherd Dogs). Stay with me for a second.

One of our GSD's developed a very serious problem a number of years ago. His skin smelled horrible and he lost all hear from his chest and belly. His coat looked dull, almost dead.

Not knowing what was going on I sought advice from our vet. He suggested I take him to a veterinary dermatologist. $2,500 and bunch of shots and pills later, we went home with a plan. Pop pills every day. Get this magical shot once a month.

Sure enough, in about four weeks his coat was nice and shinny again, his skin didn't smell and hair started to come back to his chest.

Back we went for another shot and more pills. This was running about $600 per month. The dermatologist said he'd have to be on this program for the rest of his life. Wow.

I decided to reach out to a number of GSD groups and breeders. A theme emerged from these conversations very quickly: Change his food. He is having allergic reaction to his food. Stop the nonsense the dermatologist is selling you.

So, I did. I figured I could try for a couple months and, if nothing changed, go back to the treatment.

We went with a high quality food with twice the protein content and far less junk carbs, etc.

Less than a month later this dog was in what I might describe as the best shape of his life. He looked great, was happy, didn't have smelly skin, his coat grew back on this chest and belly and was pretty much the picture of a healthy dog. This was many years ago. He has been on this better-food diet every since and looks and feels wonderful.

We have lost sense of just how important good food is for our bodies and minds. We accept that the garbage we buy at the market and restaurants is normal. Well, it isn't. This is the problem. The vet dermatologist was administering a government approved drug to my dog. It worked. And yet that was not really the solution, because it did not address the underlying problem. And that's the issue I have this startup. It isn't a solution. At all. Nobody needs this to lose weight.

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