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Aspartame and cancer – new evidence for causation

ncbi.nlm.nih.gov

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Re: Aspartame and cancer – new evidence for causation

#151
post #67
post #45

Aspartame isn't just widely consumed, it's practically universally consumed. If it was carcinogenic in humans, wouldn't there be obvious epidemiological evidence to back that up?

I used to work on DNA dyes. Typically when you see a 6 carbon ring with a chain of carbons attached, there is high probability of that molecule interfering with DNA replication. Basically the mechanism works because the hexagon ring slides between the base pairs and this leads to a lowest energy state due to a phenomenon call pi orbital stacking resulting in the molecule getting stuck there. The carbon chain is mostl…

> Take a look at ethidium bromide or pretty much any other intercalating dna stain and you’ll see similar characteristics. It’s also extremely carcinogenic.

This is a myth. This is actually a good example of a plausible biological effect that doesn't apply to living organisms:

https://blogs.sciencemag.org/pipeline/archives/2016/04/18/th...

Re: Aspartame and cancer – new evidence for causation

#152
post #148

I treat artificial sweeteners like I do mask wearing -- I'm not sure how much difference wearing a mask makes for my safety and safety of others, but I wear it anyway because it's a very minor inconvenience and it probably helps. I avoid artificial sweeteners because I'm not sure if they have any detrimental effects, but I avoid them anyway because it's a minor inconvenience, and whether they are actually harmful or…

Except mask wearing actually has scientific evidence for its effectiveness, and is why governments around the world recommend it. [1] Your rationale is based on personal bias against "artificial" substances. The same kind of quack reasoning that drives anti vaxers and other nonsense movements. [1] https://jamanetwork.com/journals/jama/fullarticle/2776536

Aren’t most “artificial” substances more likely to be carcinogenic or toxic than something occurring naturally? Or is that just my wacky personal bias talking?

Re: Aspartame and cancer – new evidence for causation

#153
post #148

I treat artificial sweeteners like I do mask wearing -- I'm not sure how much difference wearing a mask makes for my safety and safety of others, but I wear it anyway because it's a very minor inconvenience and it probably helps. I avoid artificial sweeteners because I'm not sure if they have any detrimental effects, but I avoid them anyway because it's a minor inconvenience, and whether they are actually harmful or…

Except mask wearing actually has scientific evidence for its effectiveness, and is why governments around the world recommend it. [1] Your rationale is based on personal bias against "artificial" substances. The same kind of quack reasoning that drives anti vaxers and other nonsense movements. [1] https://jamanetwork.com/journals/jama/fullarticle/2776536

Being insulting isn't going to change anyone's mind. In fact, it'll probably persuade people in the opposite direction.

Re: Aspartame and cancer – new evidence for causation

#154
post #45

Aspartame isn't just widely consumed, it's practically universally consumed. If it was carcinogenic in humans, wouldn't there be obvious epidemiological evidence to back that up?

> practically universally consumed I take issue with this, frankly. Aspartame seems to be particularly popular in the USA (diet sodas), and less popular the further away you go. It's used in other stuff, sure, but most products outside of the USA just use sugar or corn-syrup-based sweeteners. I don't think anyone in my circle of family or friends has had a diet soda in decades, save for exactly one individual who dri…

> Aspartame seems to be particularly popular in the USA (diet sodas), and less popular the further away you go.

At least in Germany, it’s very similar. Most diet sodas here are aspartame sweetened.

Re: Aspartame and cancer – new evidence for causation

#155
post #148

I treat artificial sweeteners like I do mask wearing -- I'm not sure how much difference wearing a mask makes for my safety and safety of others, but I wear it anyway because it's a very minor inconvenience and it probably helps. I avoid artificial sweeteners because I'm not sure if they have any detrimental effects, but I avoid them anyway because it's a minor inconvenience, and whether they are actually harmful or…

Except mask wearing actually has scientific evidence for its effectiveness, and is why governments around the world recommend it. [1] Your rationale is based on personal bias against "artificial" substances. The same kind of quack reasoning that drives anti vaxers and other nonsense movements. [1] https://jamanetwork.com/journals/jama/fullarticle/2776536

Artificial sweeteners have even more evidence for the safety.

I agree with your second point but I generally take a lot more issue with the lack of skepticism put towards the alternatives rather than the skepticism towards science.

Evenly applied skepticism leads you to accept the thing which has the most evidence in support while also letting you change your mind if the evidence changes. The problem with the "alternative" medicine crowd is that evidence didn't lead them to their conclusion so evidence can't lead them out.

Re: Aspartame and cancer – new evidence for causation

#156
post #148

Earlier quoted context omitted.

Except mask wearing actually has scientific evidence for its effectiveness, and is why governments around the world recommend it. [1] Your rationale is based on personal bias against "artificial" substances. The same kind of quack reasoning that drives anti vaxers and other nonsense movements. [1] https://jamanetwork.com/journals/jama/fullarticle/2776536

Aren’t most “artificial” substances more likely to be carcinogenic or toxic than something occurring naturally? Or is that just my wacky personal bias talking?

There are plenty of "natural" carcinogens. Tobacco, for example, is perhaps the largest single cause of cancer in human history.

Re: Aspartame and cancer – new evidence for causation

#157
post #98

Earlier quoted context omitted.

Ah, yes, replace 'sweets' with 'fruits' which are about 50-75% sugar by non-water mass. Eg strawberries - 100 g is 7.7g of carbohydrates (4.9g sugar), 0.7g protein, 0.3g fat. 56% sugar. Or oranges - 165 g without membrane or peel is 20.7g carbs (14g sugar), 1.5g protein, 0.2g fat. 63% sugar. As opposed to, say, a snickers bar. 9.1g carbohydrates (7.6g sugar), 1.1g protein, 3.6g fat. 55% sugar. Or a kitkat. 27.1g carb…

I think the issue isn't just the pure carb content. 100g of strawberries is a lot of strawberries. 100 g of Snickers bars is... two bars. I can easily eat two and then crave another one right away. After 100 g of strawberries, I'm pretty much done for a while. Same with say, apples. I think one thing that is usually overlooked in these discussions is the "feeling" part of it, for lack of a better term. Some things ma…

100 grams of strawberries looks to be about 8-10 large strawberries

http://www.wholefoodsplantbasedhealth.com.au/wp-content/uplo...

Re: Aspartame and cancer – new evidence for causation

#158

I treat artificial sweeteners like I do mask wearing -- I'm not sure how much difference wearing a mask makes for my safety and safety of others, but I wear it anyway because it's a very minor inconvenience and it probably helps. I avoid artificial sweeteners because I'm not sure if they have any detrimental effects, but I avoid them anyway because it's a minor inconvenience, and whether they are actually harmful or…

I'm pretty sure the increased cancer rates and cardiovascular incidents caused by obesity far exceeds the the little aspartame-cancer causation studies have demonstrated so far.

Re: Aspartame and cancer – new evidence for causation

#159
post #111

Earlier quoted context omitted.

> However these cases of polymer fume fever were mostly present in people who had cooked at 390 °C (734 °F) for ≥4 hours. My oven goes up to 250 °C, though I never use it above 220. What cooking processes go to each of these thresholds?

Frying.

I thought oil boiled at 300 °C, how do you get up to 390 °C?

Re: Aspartame and cancer – new evidence for causation

#160

Earlier quoted context omitted.

Aspartame also rapidly "breaks down into residual components, including aspartic acid, phenylalanine, methanol, and further breakdown products including formaldehyde and formic acid" on ingestion. [1] Even with no smoking gun for cancer, why would anyone tempt fate after reading that? [1] https://en.wikipedia.org/wiki/Aspartame#Metabolites

You forgot the second half of the paragraph from your source: > Human studies show that formic acid is excreted faster than it is formed after ingestion of aspartame. In some fruit juices, higher concentrations of methanol can be found than the amount produced from aspartame in beverages. Also: > Aspartame consists of two amino acids—aspartic acid and phenylalanine. When ingested, aspartame is broken down into these…

Yep I earned those downvotes, thanks.

That's a useful website.

Since who drinks tomato juice, really, another way to put it is that you'd need about 20 large Diet Cokes (32 oz each, no ice) per day to get the same amount of methanol as from a diet rich in ripe fruits (1000 mg/day).

https://cot.food.gov.uk/sites/default/files/cot/cotstatement...

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