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Aspartame and cancer – new evidence for causation

ncbi.nlm.nih.gov

81–90 of 315 posts

Re: Aspartame and cancer – new evidence for causation

#81
post #4

Note that it is in rodent. Aspartame hadn't been confirmed as a carcinogenic agent in humans. That said, I don't think it's a good idea to subject to ourselves to drinking diet soda as a daily habit. It costs money, may or may not interfere with your blood sugar and the health of your gut microbiomes. As a goal, I limit my intake of any sweet and/or artifically sweetened drinks. Instead of being a chronic diet coke d…

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Re: Aspartame and cancer – new evidence for causation

#82
post #10
post #4

Note that it is in rodent. Aspartame hadn't been confirmed as a carcinogenic agent in humans. That said, I don't think it's a good idea to subject to ourselves to drinking diet soda as a daily habit. It costs money, may or may not interfere with your blood sugar and the health of your gut microbiomes. As a goal, I limit my intake of any sweet and/or artifically sweetened drinks. Instead of being a chronic diet coke d…

not only is it rodent the amount of Aspartame / kilogram is huge even at their lowest value (20mg/kg). Coke no sugar has ~87 mg of Aspartame in it, you need to do drink ~20 cans of it to meet the same Aspartame level in a 90kg human.

Artificial sweeteners are in more than just sodas.

The number of food products that traditionally didn't have sweetners in, that now have aspartame is increasing. That is concerning for me.

Re: Aspartame and cancer – new evidence for causation

#83
post #54
post #50

Earlier quoted context omitted.

It's not unreasonable to assume that the current rate of disease in our populations might be able to be lower since we weren't tracking the association of the introduction of products to safety in years past as well as we do today. A better question is, suppose it was known that it did create a small but measurable in lifetime cancer risk, would you actually want to keep consuming it? EDIT: Also aspartame is hardly u…

I don't know, like everybody else, I eat things with substantial amounts of acrylamide, which is a carcinogen we actually know is problematic, unlike aspartame. You're commenting on a story that suggests that even small exposures to aspartame might be dangerous. And you stopped drinking diet soda only recently. I think you might have a hard time finding an American (for instance) that hadn't consumed a substantial am…

Depends how much I was drinking (that varies substantially across the population) but cancer risk usually doesn't track exactly with total exposure compared to ongoing exposure - i.e. when you quit smoking your lung cancer risk decreases the longer you stay quit, until after 5-7 years it tends to level out at about the normal population level.

Re: Aspartame and cancer – new evidence for causation

#84
post #62

Earlier quoted context omitted.

O? What’s alcohol got to do with aspartame?

Scientists think that up to 50% of cancer might come from alcohol consumptions, but it’s apparently quite hard to study.

I went effectively teetotal around 2007 (I got spectaculary blackout drunk - woke up nearly a day later and couldn't remember getting home or much of the 8hrs prior to that - decided that was a silly way to live and quit).

Honestly not something I miss, I raise a glass of whiskey every xmas in remembrance of my grandfathers (Irish one side, Scottish the other).

Otherwise never, it's fun when the doc/nurse asks "How any units do you drink?" "About one per year" it's such a massive in-grained part of our culture (I'm British) still.

Though the youngsters coming up now drink way less than I did at 18 in 1998 - partly cost and partly a greater awareness of the damage (plus there is just so much more for the average teenager to do now).

The evidence on alcohol and pariculary mouth/oesphagal problems is pretty compelling but I'm not a doctor.

Re: Aspartame and cancer – new evidence for causation

#85
post #23

Earlier quoted context omitted.

Considering how widespread Aspartame on a societal level, you'd think there'd be epidemiologic evidence of increasing cancer rates over that time. Maybe there is some literature on it, but I hadn't heard.

The problem is that we have introduced so many new chemicals recently and have seen so many unexplained changes to health. Its virtually impossible to work out which thing did what. I'm not going to stress over aspartame though. Plastics, PFOA, PTFE, processed meats, and air pollution are way above on my concern scale. If I was concerned about cancer from aspartame, I would never touch any form of alcohol again.

PTFE? It’s so non-reactive that it is commonly used in medical implants, precisely because of its high biocompatibility. I don’t think that there are any connections at all between PTFE and cancer.

Re: Aspartame and cancer – new evidence for causation

#86
post #67
post #45

Aspartame isn't just widely consumed, it's practically universally consumed. If it was carcinogenic in humans, wouldn't there be obvious epidemiological evidence to back that up?

I used to work on DNA dyes. Typically when you see a 6 carbon ring with a chain of carbons attached, there is high probability of that molecule interfering with DNA replication. Basically the mechanism works because the hexagon ring slides between the base pairs and this leads to a lowest energy state due to a phenomenon call pi orbital stacking resulting in the molecule getting stuck there. The carbon chain is mostl…

If that hypothesis were true, it would implicate not just phenylalanine, but dopamine, epinephrine, diphenhydramine, ibuprofen, paracetamol, limonene, vanillin, cinnamaldehyde, and literally thousands of other different molecules, natural and synthetic, we constantly interact with. Heck, most polyphenols have pi-conjugation, and those are widely thought to have antioxidant and anticancer effects. Oh and I completely forgot about the indole moiety (tryptophan).

Intercalation is way more complicated than just some flat pi-bonded moieties. If that's all it took, we'd see everyone getting cancer like...rats...oooohhhh, I wonder...

Maybe rodents (especially Sprague rats) are way more vulnerable to intercalation? That would explain why so many things cause cancer - weak recovery mechanisms for DNA replication errors. I need to look into this further.

Anyway... the pattern I see across known intercalators is large, multi-ring (3 or more) fused flat structures. Like PAHs.

Re: Aspartame and cancer – new evidence for causation

#87
One of the lowest effort healthy lifestyle changes you can make is to wean your body off of craving sweets. Artificial sweeteners still make you crave sweets.

Replace sweetened drinks with unsweetened tea (there are hundreds of varieties, you will find something that you like).

Replace desserts with your favorite fruit or berries.

Your body, mind, and teeth will thank you.

Re: Aspartame and cancer – new evidence for causation

#88

One of the lowest effort healthy lifestyle changes you can make is to wean your body off of craving sweets. Artificial sweeteners still make you crave sweets. Replace sweetened drinks with unsweetened tea (there are hundreds of varieties, you will find something that you like). Replace desserts with your favorite fruit or berries. Your body, mind, and teeth will thank you.

> Artificial sweeteners still make you crave sweets.

How do you know that this is true?

Re: Aspartame and cancer – new evidence for causation

#89
post #4

Note that it is in rodent. Aspartame hadn't been confirmed as a carcinogenic agent in humans. That said, I don't think it's a good idea to subject to ourselves to drinking diet soda as a daily habit. It costs money, may or may not interfere with your blood sugar and the health of your gut microbiomes. As a goal, I limit my intake of any sweet and/or artifically sweetened drinks. Instead of being a chronic diet coke d…

Same. The only times I drink sugary drinks are on the weekends. Otherwise it’s water for me.

Unfortunately moderation is lost on most people.

Re: Aspartame and cancer – new evidence for causation

#90
post #85

Earlier quoted context omitted.

The problem is that we have introduced so many new chemicals recently and have seen so many unexplained changes to health. Its virtually impossible to work out which thing did what. I'm not going to stress over aspartame though. Plastics, PFOA, PTFE, processed meats, and air pollution are way above on my concern scale. If I was concerned about cancer from aspartame, I would never touch any form of alcohol again.

PTFE? It’s so non-reactive that it is commonly used in medical implants, precisely because of its high biocompatibility. I don’t think that there are any connections at all between PTFE and cancer.

"While PTFE is stable and nontoxic at lower temperatures, it begins to deteriorate after the temperature of cookware reaches about 260 °C (500 °F), and decomposes above 350 °C (662 °F).[58] Over 400 °C (752 °F) pyrolysis occurs and more decomposition becomes significantly more rapid. The main decomposition products are tetrafluoroethylene (TFE) and difluorocarbene radicals (RCF2).[58] The degradation by-products can be lethal to birds,[59] and can cause flu-like symptoms[60] in humans—see polymer fume fever."

https://en.wikipedia.org/wiki/Polytetrafluoroethylene#Safety

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