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Launch YC S21: Meet the Batch, Thread #6

news.ycombinator.com

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Re: Launch YC S21: Meet the Batch, Thread #6

#91

Post by rdifazio »

dbieber wrote: post #82
rdifazio wrote: post #5

Hey everyone! We’re Juliana and Robert, co-founders of Parallel Bio. We're improving drug discovery by replacing animal models, in the hope of making cures for humans, not mice. The biggest reason why 92% of new drugs fail is that drugs are currently discovered in mice, which are not realistic models of human disease but are used due to the challenges of working in humans. We've created a human ‘immune system in a di…

Heads up I went to email you a congratulatory email at hello@parallel.bio but my email was rejected. Might want to double check your google groups settings.

Thanks for the heads up. We're looking into it, but in the meantime robert at parallel.bio or founders at are both good email addresses.

Re: Launch YC S21: Meet the Batch, Thread #6

#92

Post by rdifazio »

car wrote: post #89
rdifazio wrote: post #5

Hey everyone! We’re Juliana and Robert, co-founders of Parallel Bio. We're improving drug discovery by replacing animal models, in the hope of making cures for humans, not mice. The biggest reason why 92% of new drugs fail is that drugs are currently discovered in mice, which are not realistic models of human disease but are used due to the challenges of working in humans. We've created a human ‘immune system in a di…

Amazing and very cool! A couple of questions, if you can share at this time, since this resonates with my interests. - Which patient/donor cell type are these immune organoids derived from? - Are the organoids made with induced pluripotent stem cell technology? - What is part of the workup post treatment, e.g. histology, NGS? If NGS, what kind (WGS, WES, RNASeq) and technologies (Illumina, PacBio, ONT)? - Are you loo…

Thanks for the feedback! I'm happy to share more.

- They're derived from secondary lymphoid tissue. We're trying to biobank as broadly as we can to capture sex, age, race, HLA, genetics, and other characteristics in a wide net.

- These are not iPSC-derived organoids.

- This depends on the readout but workup post treatment so far has included histology, immunofluorescence, serology (ELISA, SPR, etc.), CyTOF and other flow, broad RNA-seq, bulk and single cell repertoire sequencing for B and T cells, and MSD/Luminex.

- We haven't looked for mutations from drug and vaccine treatment. We'd love to know more about what you're thinking there.

Re: Launch YC S21: Meet the Batch, Thread #6

#93

Post by _2rxu »

mathackernews wrote: post #88
_2rxu wrote: post #6

We are the founders of Kodex ( https://www.kodex.us ). Kodex makes it easy for companies to process and respond to subpoenas from governments around the world. Government agencies subpoena user data from thousands of companies around the world, and companies largely rely on email, fax, and spreadsheets to manage them. At a previous job, we would frequently see companies struggle to comply with legal orders, because t…

Congrats on the launch. What's the hardest thing you have found getting Kodex to this point? How many government bodies are you connected to? Can you use your platform even if they do not use it? Do you use a subscription pricing model?

Great questions! The hardest part was probably getting our initial customer. This is inherently sensitive company info, and getting the initial social proof & trust from a big name opened a lot of doors for others to trust us.

We have about 60 agencies verified with us so far. What's interesting about this problem is that the company dictates how government agencies contact them. As a result, the moment our customers adopt Kodex, they automatically pull in any government agency that wants to contact them. We have new government agents signing up everyday to send our customers requests.

We do use an annual subscription pricing model.

Happy to connect offline!

Re: Launch YC S21: Meet the Batch, Thread #6

#94

Post by wizwit999 »

_2rxu wrote: post #6

We are the founders of Kodex ( https://www.kodex.us ). Kodex makes it easy for companies to process and respond to subpoenas from governments around the world. Government agencies subpoena user data from thousands of companies around the world, and companies largely rely on email, fax, and spreadsheets to manage them. At a previous job, we would frequently see companies struggle to comply with legal orders, because t…

How big is the market? It seems people who really need this and see it frequently have the resources to build their own and its otherwise rare enough to not be worth a whole product.

Re: Launch YC S21: Meet the Batch, Thread #6

#95

Post by jdmcd »

Etai wrote: post #2

Hey HN, I’m Etai, together with Andrew a co-founder of Secoda ( https://www.secoda.co ). Secoda is a collaborative workspace for data teams that makes it easy to share metadata, queries, charts and documentation with any employee. Companies store a growing amount of knowledge in BI tools, data warehouses, data pipelines, queries and documentation. Because these tools are not connected, it has become more difficult to…

This looks really cool, but not being able to self-host without an enterprise plan is a deal breaker for us :( We use Metabase right now not because we like it but because we can host it on our own servers, with our own firewalls, behind our own Cloudflare Access rules, etc etc. Understand why you might have chosen to go this route, though. Best of luck!

Re: Launch YC S21: Meet the Batch, Thread #6

#96

Post by jacquesm »

rdifazio wrote: post #90
jacquesm wrote: post #87

Earlier quoted context omitted.

If it's ok with you I will point some investors in your direction that are doing deals in this space.

Please do, and I appreciate the introductions! My email is robert at parallel.bio.

I've sent you an email, we'll take it from there.

Re: Launch YC S21: Meet the Batch, Thread #6

#97

Post by mike_d »

_2rxu wrote: post #6

We are the founders of Kodex ( https://www.kodex.us ). Kodex makes it easy for companies to process and respond to subpoenas from governments around the world. Government agencies subpoena user data from thousands of companies around the world, and companies largely rely on email, fax, and spreadsheets to manage them. At a previous job, we would frequently see companies struggle to comply with legal orders, because t…

I think this is really great. Do you have a public transparency report feature on the roadmap?

Re: Launch YC S21: Meet the Batch, Thread #6

#98

Post by _2rxu »

mike_d wrote: post #97
_2rxu wrote: post #6

We are the founders of Kodex ( https://www.kodex.us ). Kodex makes it easy for companies to process and respond to subpoenas from governments around the world. Government agencies subpoena user data from thousands of companies around the world, and companies largely rely on email, fax, and spreadsheets to manage them. At a previous job, we would frequently see companies struggle to comply with legal orders, because t…

I think this is really great. Do you have a public transparency report feature on the roadmap?

We do already offer company specific transparency reports, so they can analyze the threats on their platform and the agencies investigating them! We have also been thinking more generically about offering a public transparency report that doesn't give away any customer specific details.

Love to know your thoughts!

Re: Launch YC S21: Meet the Batch, Thread #6

#99

Post by _2rxu »

wizwit999 wrote: post #94
_2rxu wrote: post #6

We are the founders of Kodex ( https://www.kodex.us ). Kodex makes it easy for companies to process and respond to subpoenas from governments around the world. Government agencies subpoena user data from thousands of companies around the world, and companies largely rely on email, fax, and spreadsheets to manage them. At a previous job, we would frequently see companies struggle to comply with legal orders, because t…

How big is the market? It seems people who really need this and see it frequently have the resources to build their own and its otherwise rare enough to not be worth a whole product.

I'm glad you brought that up!

I think that is the most common misconception with this problem, and that is why it has gone so long without a solution. You are correct in that the biggest players (i.e. big tech) are the ones who have the resources to solve their own problems. However, this problem spreads much further and wider than just big tech. There are thousands of companies in the US alone that get these requests (from ISPs, banks, insurance, fintechs, crypto, tech, etc.). "Big tech" typically gets all the focus because of the volume they get (FB gets 300k+ per year). What goes unnoticed is that even at 100+, or 1000+ per year, these requests are very overwhelming for companies to manage. These are also the companies that don't have the internal resources to fix their pain like FB and Google.

Re: Launch YC S21: Meet the Batch, Thread #6

#100

Post by _2rxu »

_2rxu wrote: post #99
wizwit999 wrote: post #94

Earlier quoted context omitted.

How big is the market? It seems people who really need this and see it frequently have the resources to build their own and its otherwise rare enough to not be worth a whole product.

I'm glad you brought that up! I think that is the most common misconception with this problem, and that is why it has gone so long without a solution. You are correct in that the biggest players (i.e. big tech) are the ones who have the resources to solve their own problems. However, this problem spreads much further and wider than just big tech. There are thousands of companies in the US alone that get these request…

To answer your question about the market, there are ~30k companies that are vulnerable to data requests in the US alone. At $100k price point, that is roughly a $3B market
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