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Launch YC S21: Meet the Batch, Thread #6

news.ycombinator.com

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Re: Launch YC S21: Meet the Batch, Thread #6

#41

Post by jacquesm »

ramraj07 wrote: post #18
jacquesm wrote: post #11

Earlier quoted context omitted.

On behalf of all the mice, thank you very much for doing this. I'm all for modern medicine but the number of mice, primates and other mammals that we kill in the name of science every year does not sit right with me.

I’ve always felt that if there was _any_ morally acceptable reason to harm and kill animals it is for the sake of (reasonable) medical research. In principle the ethics board is there to make sure this is true but in practice they rarely do anything about it. Perhaps the real way to solve that problem is hold the IrBs to a higher standard and make them do their job?

I always try to reverse a situation to see if it makes sense, and then I ask myself: what would we think if aliens came to earth to experiment on us with untested medicine, kill us afterwards and only when it is perfectly safe on us they would apply it to themselves. I believe a large fraction of humanity would say that that is unethical and they'd have all kinds of cognitive dissonance to deal with (and associated reasons why this is different) to explain why what we do is ok.

I personally don't think it is ok, but it apparently is a necessity, at the same time if this can be stopped then that would be great.

Re: Launch YC S21: Meet the Batch, Thread #6

#42

Post by [deleted] »

dr_ wrote: post #40
ycorvar wrote: post #7

Hi there! We are Orestis and Urs from Zeit Medical ( https://www.zeitmedical.com ). We enable fast stroke detection at home. 90% of strokes go untreated due to stroke recognition delays. Many patients live in fear that a stroke might happen and go unnoticed for hours, particularly if they are asleep when it starts. Stroke is currently impossible to detect based on symptoms. Unlike a heart attack, there is no distinct…

Congrats on your launch. Question, if the device is suggesting the user may be developing a stroke - what do they do? Do they go to the ER and show the docs that there’s abnormal electrical activity so imaging of the brain must be done? Without physical symptoms, I’m not sure most ERs would be prepared to deal with this…or would they? Or is it assumed symptoms would develop by the time the patient arrives to the ER?

[deleted]

Re: Launch YC S21: Meet the Batch, Thread #6

#43

Post by ycorvar »

WORMS_EAT_WORMS wrote: post #19
ycorvar wrote: post #7

Hi there! We are Orestis and Urs from Zeit Medical ( https://www.zeitmedical.com ). We enable fast stroke detection at home. 90% of strokes go untreated due to stroke recognition delays. Many patients live in fear that a stroke might happen and go unnoticed for hours, particularly if they are asleep when it starts. Stroke is currently impossible to detect based on symptoms. Unlike a heart attack, there is no distinct…

Super neat… - How common are strokes generally? Seems like a lot to wear this all the time — but also I’m not familiar with the risk factor. - How much quicker is this at detecting a stroke versus someone simply observing it happening with a naked eye? Like how much time does this save over simply seeing physical symptoms with your naked eye or feeling the symptoms for yourself? 1 second, 1 hour, 5 hours, days?

Hi WORMS_EAT_WORMS

Great questions!

1) For the US-> There are approximately 1 million strokes every year. Stroke is the #1 cause of disability

2) Good point. We are starting with a system that can be work at night time + whenever the users feel most vulnerable. There are many patients who who through periods of increased risk (i.e. after a 1st stroke, after a transient ischemic attack).

3)Stroke recognition is one of the biggest pain points in bringing stroke victims to treatment. Strokes that happen during sleep (commonly referred to also as wake up strokes) are practically impossible to detect based on symptoms. There is not pain associated with it (like in a heart attack).

4) We have heard crazy stories from patients and caregivers about how different their outcome would have been had they been alerted a couple of hours earlier. Our vision is to help everyone go to the hospital in under 1h. Our first target is to enable everyone to go to the hospital within 4h which is currently the time window for tpa d (clot busting medication). What's the current status? -> only 4% nationwide get tpa because they arrive too late.

If you know when the stroke started and its more than 5h past that -> no tpa.

If you don't know when the stroke started -> no tpa.

Re: Launch YC S21: Meet the Batch, Thread #6

#44

Post by whymauri »

rdifazio wrote: post #5

Hey everyone! We’re Juliana and Robert, co-founders of Parallel Bio. We're improving drug discovery by replacing animal models, in the hope of making cures for humans, not mice. The biggest reason why 92% of new drugs fail is that drugs are currently discovered in mice, which are not realistic models of human disease but are used due to the challenges of working in humans. We've created a human ‘immune system in a di…

Very cool and promising. Is there any literature on this "immune system in a dish", or is it ,understandably, proprietary?

Three main Q:

* How's reception been with med chemists?

* How do you expect cost to compare with some of the individual existing immunological wet lab screens? No individual numbers, just comparative would be interesting to know.

* How granular is data collection for this kinda all-in-one system, and is throughput high enough to collect data and build predictive models alongside it?

I used to work in the earlier stages of drug discovery and advances in these assays are fascinating. Really exciting work, guys!

Re: Launch YC S21: Meet the Batch, Thread #6

#45

Post by ycorvar »

agustif wrote: post #38
ycorvar wrote: post #7

Hi there! We are Orestis and Urs from Zeit Medical ( https://www.zeitmedical.com ). We enable fast stroke detection at home. 90% of strokes go untreated due to stroke recognition delays. Many patients live in fear that a stroke might happen and go unnoticed for hours, particularly if they are asleep when it starts. Stroke is currently impossible to detect based on symptoms. Unlike a heart attack, there is no distinct…

Could this be used outside of the US? Like in Mexico Would it be useful for someone who had small lacunar strokes which provoked parkinson? Thanks, awesome company

Thank you for your comments!

1) Currently focusing on clearing the FDA in the US. One of our clinical advisors is very passionate about helping bring this also to Mexico. Please sign up in our waitlist and we will make sure to keep you posted.

2) You are raising a very good point about lacunar strokes. In general these are deeper in the brain structures and not easily picked by cortical-level brain activity monitoring. However we feel confident that once our product is regulatory cleared and out there collecting data, we will be able to pick the finer effects caused by such strokes.

Re: Launch YC S21: Meet the Batch, Thread #6

#46

Post by debarshri »

Etai wrote: post #2

Hey HN, I’m Etai, together with Andrew a co-founder of Secoda ( https://www.secoda.co ). Secoda is a collaborative workspace for data teams that makes it easy to share metadata, queries, charts and documentation with any employee. Companies store a growing amount of knowledge in BI tools, data warehouses, data pipelines, queries and documentation. Because these tools are not connected, it has become more difficult to…

How does it compare to traditional reporting tools. Lot of modern day BI tools like looker for instance, do have features like this. Where do you position yours company as compared to traditional tools?

Re: Launch YC S21: Meet the Batch, Thread #6

#47

Post by rdifazio »

gtirloni wrote: post #14
rdifazio wrote: post #5

Hey everyone! We’re Juliana and Robert, co-founders of Parallel Bio. We're improving drug discovery by replacing animal models, in the hope of making cures for humans, not mice. The biggest reason why 92% of new drugs fail is that drugs are currently discovered in mice, which are not realistic models of human disease but are used due to the challenges of working in humans. We've created a human ‘immune system in a di…

Why is your website empty?

We're in the process of launching and are working on coming out of stealth as fast as we can. It shouldn't be empty in the near future!

Re: Launch YC S21: Meet the Batch, Thread #6

#48

Post by andrewmcewen »

debarshri wrote: post #46
Etai wrote: post #2

Hey HN, I’m Etai, together with Andrew a co-founder of Secoda ( https://www.secoda.co ). Secoda is a collaborative workspace for data teams that makes it easy to share metadata, queries, charts and documentation with any employee. Companies store a growing amount of knowledge in BI tools, data warehouses, data pipelines, queries and documentation. Because these tools are not connected, it has become more difficult to…

How does it compare to traditional reporting tools. Lot of modern day BI tools like looker for instance, do have features like this. Where do you position yours company as compared to traditional tools?

The main way that Secoda differs from a traditional reporting tool is that we offer a more complete view into the data knowledge/context of an organization. A traditional reporting tool like Looker does great for reports, but it misses context about how certain models are created, where data is coming from downstream, and more general knowledge that is stored inside of a wiki. Secoda takes all of the context across a data stack and puts it in one central place. So we actually see ourselves as complementary to these reporting tools as we are a layer on top of them.

Re: Launch YC S21: Meet the Batch, Thread #6

#49

Post by kall »

imharkunwar wrote: post #34
natemwilson wrote: post #32

Earlier quoted context omitted.

Based on their logo it looks like: "one is to x"

On point - Its /wan-iz-tu-ex/ - referring to scale like 1:100, 1:500, 1:5 etc. In design, especially tangible design subjects like industrial design and architecture, everything is prototyped at some scale or proportions that is friendly to understand the design development.

If you have already considered this enough, disregard my comment..This name really trips me up as a german reader. If you like that it‘s a bit out there, that’s cool. If you want most people to read it like you just explained, you might need to capitalize the individual words.

Edit: just saw your logo. That reads well on first glance.

Re: Launch YC S21: Meet the Batch, Thread #6

#50

Post by jitl »

ycorvar wrote: post #28
jitl wrote: post #17

Earlier quoted context omitted.

How do outcomes for stroke patients vary based on treatment?

Time to treatment is the most important factor in defining stroke treatment outcomes. Stroke outcomes are quantified at 90d post event with a metric called Modified Rankin Scale. The treatment strategy is defined based on the type, location, and severity. The two options we have for ischemic strokes (i.e.85% of all strokes) are TPA (clotbusting medication) and thrombectomy (catheter based mechanical removal of the cl…

I think you should further synthesize and emphasize these facts in your marketing - otherwise, the impact and importance of your work isn't apparent to laypeople.
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