Live data from Hacker News

With a nudge from AI, ketamine emerges as a potential rare disease treatment

statnews.com

131–140 of 140 posts

Re: With a nudge from AI, ketamine emerges as a potential rare disease treatment

#131
post #82

Earlier quoted context omitted.

I dunno about illegal drugs, they're illegal for a reason.

"I dunno about illegal drugs, they're illegal for a reason. " They're illegal for many reasons, which are mostly: stupid, unjust, racist, harmful, and hypocritical. Alcohol is one of the most harmful "recreational" drugs, but it's still perfectly legal, and no one is seriously proposing we make it illegal again, despite all the violence, addiction, sickness, and death it causes. Virtually all of the illegal drugs are…

Also, some of the most illegal drugs that are classified as highly addictive with no medical use are literally orders of magnitude less harmful and addictive than for example meth, which is acknowledged to at least have some medical use.

Re: With a nudge from AI, ketamine emerges as a potential rare disease treatment

#132
post #32

Earlier quoted context omitted.

Thanks for pointing this out. I don’t know enough about kratom to have an opinion on how it should be regulated. I will add a comment though. Just because I am fundamentally opposed to America regulating drug use outside of its territory.

https://www.drugabuse.gov/publications/drugfacts/kratom

I will assume anything written under such a link to be false unless proven otherwise.

Re: With a nudge from AI, ketamine emerges as a potential rare disease treatment

#133

Earlier quoted context omitted.

>I’m glad we are moving away from the incredibly destructive drug policies that have been in place for so long The point of the polices was to counter the incredibly destructive result of the surge of cocaine, crack, heroin use in the mid 1970s and early to mid 1980s. And the deaths from the drug use and the gangs fighting over the spoils. It really was a war. Mexico didn't seem to make it, I think the drugs won. I k…

Ironically you are describing the consequences of the "war on drugs" which started in 1971. Many overdose deaths are directly related to the unknown quality of black market drugs. There would be no gangs "fighting over the spoils" if it were legal. You are conflating the consequences of prohibition with the consequences of drug use. That isn't to say all drugs are good, but as we learned in the 1920s prohibition is a…

Thanks for saying this. The parent comment just shows how deeply the propaganda has worked. There would be no gangs fighting and much lower levels of overdose and abuse if you could pick up your cheap, clean, legal cocaine/heroin/etc. at an official dispensary if you needed it. Portugal is showing the way.

Re: With a nudge from AI, ketamine emerges as a potential rare disease treatment

#134
post #103
post #76

Earlier quoted context omitted.

opioids are a large class of drugs with widely varying effects and potential for abuse. for instance, the active ingredient in Imodium is an opioid, but you don't see a lot of recreational Imodium users. kratom is certainly not a miracle herb, but its characteristics do make it a lot less addictive and lethal than its more popular relatives. it's not unreasonable to think it might be used in replacement therapy, simi…

- kratom is certainly not a miracle herb, but its characteristics do make it a lot less addictive and lethal than its more popular relatives. Yea, that's what you read online. But after going 2.5 months without sleep (I would doze off for half an hour once a twice per night), 4 months of acute depression, and umm like a year of PAWS, I beg to differ. If you're going off of personal experience, congrats, you didn't ab…

Did you try weed?

Re: With a nudge from AI, ketamine emerges as a potential rare disease treatment

#135
post #123

Earlier quoted context omitted.

Is this satire?

Of course it was. I edited the comment because my thoughts on this are not welcome in "civilized society". God forbid people have some personal responsibility instead of relying on a system that tramples on the minority. But hey, it's a small minority, so fuck them, right.

> Of course it was.

Poe's law [1] -- it didn't seem like satire when I read it.

[1] https://en.wikipedia.org/wiki/Poe%27s_law

Re: With a nudge from AI, ketamine emerges as a potential rare disease treatment

#136
post #30

Earlier quoted context omitted.

One danger of chronic ketamine use is bladder damage.

But note https://astralcodexten.substack.com/p/drug-users-use-a-lot-o...

I totally agree with the perspective in that blog. I just wanted to mention one of the known dangers of chronic ketamine use in the spirit of harm-reduction, because I don't think the bladder damage risk is that well-known, and sometimes people become seduced by the charms of ketamine and end up taking the drug far more often than when they set out.

Re: With a nudge from AI, ketamine emerges as a potential rare disease treatment

#137
post #30

Earlier quoted context omitted.

One danger of chronic ketamine use is bladder damage.

From what I've read about people using Ketamine for antidepression, they tend to use a very small dose at as long an interval as possible while still being effective, while the reports of bladder damage seem to be when people use large quantities (a few grams) per day for months. That is, if you're using it medically, rather than for recreation, its probably not a risk. Even recreationally, unless you're abusing it,…

You're right, taken in a medical context there would be no risk of this. Just wanted to put the bladder damage risk on the radar, so that people are aware that there are physical consequences to abuse. You know, a lot of people self-medicate and there's a fine line between self-medication, recreation, and abuse.

Re: With a nudge from AI, ketamine emerges as a potential rare disease treatment

#138

Earlier quoted context omitted.

Sorry to burst your bubble but U.S. drug policy is not as progressive as you might think. Cannabis is still illegal under federal law. And right now America is petitioning the WHO for a GLOBAL ban on KRATOM, a herb which has been used in Asia for hundreds of years with no recorded deaths. It has been in use in Europe and America for a couple of decades and still there are no deaths recorded from pure Kratom use. Krat…

Please don’t glorify Kratom as some sort of miracle herb without downsides. Kratom is an opioid, full stop. People are under the mistaken impression that it’s less addictive because it’s less potent on a per-gram basis, but addicts simply end up consuming more grams to get similar highs. It’s not a “mood regulator” in any magical sense other than it’s an opioid and opioids temporarily put people in good moods. There…

> addicts simply end up consuming more grams to get similar highs.

That doesn’t really work with kratom. There’s a ceiling to the effects, unlike regular opiates (which kratom is not) and consuming more doesn’t produce stronger enjoyable effects. It tops out at about codeine level, or perhaps 1 hydrocodone.

Re: With a nudge from AI, ketamine emerges as a potential rare disease treatment

#139

Earlier quoted context omitted.

Please don’t glorify Kratom as some sort of miracle herb without downsides. Kratom is an opioid, full stop. People are under the mistaken impression that it’s less addictive because it’s less potent on a per-gram basis, but addicts simply end up consuming more grams to get similar highs. It’s not a “mood regulator” in any magical sense other than it’s an opioid and opioids temporarily put people in good moods. There…

Disclaimer: Don't start using opioids. You could become addicted and end up using street drugs and overdose and die. But the physiological reality is most opioids are harmless if dosed correctly. They do tend to make people happier although often less productive or driven. We should focus on harm reduction. If registered addicts can get a regular dose of a pure opioid in a safe setting they can often be productive me…

Psychedelics would be a much better choice for that sort of therapy. Opiates would be about as effective for psychological treatment as alcohol.

Re: With a nudge from AI, ketamine emerges as a potential rare disease treatment

#140

Earlier quoted context omitted.

GitHub says it's mostly written in Scheme and Racket! Would love to hear the story behind that... is this just one researcher's idiosyncratic choice, or are these languages providing some kind of material advantage in this application? (I'm aware that Lisps have a long history in AI but I understood that to be kind of in the past at this point...)

I'm the researcher mentioned in the article. We used Racket in part because before we transitioned into academic medicine, Will Byrd and I were in academic computer science with a focus on programming languages. Will was building up miniKanren to do lots of cool stuff in program synthesis and program analysis. When we jumped over, it felt natural to bring the power of relational reasoning to knowledge graphs over bio…

I am also a big fan of yours Prof Might! I am very passionate about genomics and rare diseases and your contributions (code, writings, setting up the PMI, and all the others too numerous to list them all here) in this oft neglected area have been very motivating and inspiring to me . Wish more software folks were aware of and work on these important problems at the intersection of biology and software

p.s. would love it if you do a reddit AMA

Post reply on HN