I'd be interested to see some analytics, such as how many users are there with 100+ karma because that's likely a better measure of the number of active users than the number of registered users (many of which are likely inactive). However, that doesn't account for lurkers. Or, the number of users that have logged in within the past week though this is probably something pg would have to give us because I can't think…
Rough Estimate of users with Karma > 100: http://www.google.com/search?sclient=psy&hl=en&biw=1...
However, this is indeed a very rough estimate because the parameter 100...100000 also captures the number that indicates how long ago a user account was created, so it would also count accounts that were created a while ago (over 100 days) but were inactive.