61–70 of 140 posts
"The tool, called mediKanren, scanned millions of biomedical abstracts hunting for relationships between existing compounds and the gene involved in the disease." Is this AI or someone put the effort into compiling a database and added automatic search function?
Reminds me of minikanren and I think this may be related
It feels like in the last few years I have been constantly hearing about new research showing “fun” drugs as cures to a wide array of medical conditions. There’s marijuana for chronic pain, mushrooms for depression, mdma for ptsd, and now ketamine. They are often talked about as if they have little or no harmful side effects. I’m glad we are moving away from the incredibly destructive drug policies that have been in…
One danger of chronic ketamine use is bladder damage.
It feels like in the last few years I have been constantly hearing about new research showing “fun” drugs as cures to a wide array of medical conditions. There’s marijuana for chronic pain, mushrooms for depression, mdma for ptsd, and now ketamine. They are often talked about as if they have little or no harmful side effects. I’m glad we are moving away from the incredibly destructive drug policies that have been in…
Ketamine has been in medical use for a long time as an anesthetic and has also been shown to be beneficial for depression in recent years. Its not "now" Ketamine.
It feels like in the last few years I have been constantly hearing about new research showing “fun” drugs as cures to a wide array of medical conditions. There’s marijuana for chronic pain, mushrooms for depression, mdma for ptsd, and now ketamine. They are often talked about as if they have little or no harmful side effects. I’m glad we are moving away from the incredibly destructive drug policies that have been in…
Sorry to burst your bubble but U.S. drug policy is not as progressive as you might think. Cannabis is still illegal under federal law. And right now America is petitioning the WHO for a GLOBAL ban on KRATOM, a herb which has been used in Asia for hundreds of years with no recorded deaths. It has been in use in Europe and America for a couple of decades and still there are no deaths recorded from pure Kratom use. Krat…
This is a strange claim. Kratom alkaloids appear to be opioid receptor partial agonists [1]. De-escalation from opioids to kratom makes sense. Cocaine and alcohol addiction usually do not require "maintenance" post-rehab [2,3], unlike opioid dependence which is highly persistent [4], and this seems to muddy the story of a promising treatment [5] (it may compete favorably with buspirone and methadone) by mixing in stories of polydrug users who switched from cocaine to kratom.
I think kratom deserves further investigation not because it is so miraculous but because the options for effective management of opioid use disorder are extremely limited, so I would think defenses of kratom should focus on this application in particular. It is certainly much less deadly than true opioids.
1: https://jpet.aspetjournals.org/content/376/3/410.abstract
2: https://jamanetwork.com/journals/jamapsychiatry/article-abst...
3: https://www.sciencedirect.com/science/article/pii/S037687160...
4: https://www.sciencedirect.com/science/article/pii/S014067369...
5: https://link.springer.com/article/10.1007/s40122-020-00151-x
It feels like in the last few years I have been constantly hearing about new research showing “fun” drugs as cures to a wide array of medical conditions. There’s marijuana for chronic pain, mushrooms for depression, mdma for ptsd, and now ketamine. They are often talked about as if they have little or no harmful side effects. I’m glad we are moving away from the incredibly destructive drug policies that have been in…
Yes, there's probably negative side effects, but that's true for medicines in general.
It feels like in the last few years I have been constantly hearing about new research showing “fun” drugs as cures to a wide array of medical conditions. There’s marijuana for chronic pain, mushrooms for depression, mdma for ptsd, and now ketamine. They are often talked about as if they have little or no harmful side effects. I’m glad we are moving away from the incredibly destructive drug policies that have been in…
It feels like in the last few years I have been constantly hearing about new research showing “fun” drugs as cures to a wide array of medical conditions. There’s marijuana for chronic pain, mushrooms for depression, mdma for ptsd, and now ketamine. They are often talked about as if they have little or no harmful side effects. I’m glad we are moving away from the incredibly destructive drug policies that have been in…
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>The opioid epidemic was largely caused by the idea of them being non addictive being heavy pushed by the pharmaceuticals industry.
False - there was never the "idea" that these were non-addictive - it was an active, malicious, evil fucking LIE.
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One of the co-founders of Cisco, and one of the fathers of the Border Gateway Protocol (BGP), (as well as RIP, etc) - - which is aurguably the foundations of routing which makes the Internet possible, stated, in response to Hoffman's 100th birthday celebration (the discoverer of LSD):
(Paraphrased, mostly: "I was opposed to drug testing of employees at Cisco as we scaled -- if it weren't for LSD we wouldn't have been able to come up with many of the complex concepts behind BGP"
Here is one article on it:
https://www.wired.com/2006/01/lsd-the-geeks-wonder-drug/
I know first hand how much Drug/"anti-Culture" is imbued in Silicon Valley, computing in general.
I have done many a drug with many a people who have built the shit that the world lives and thrives on daily.
There is a STARK difference between a mood altering suppressant such as an opioid and expand nootropic drugs, such as LSD and Shrooms. Both of which are IMO some of the most important psycho-actives we have.
You are touching something (your machine) and consuming content (netflix etc) built by many people who have benefited, and thus had you benefit, from their experiences with 'altered-conscious'....
The Sackler Family is an evil piece of shit family that should be worse than in prison....
But The internet and Computing as we know it, would not exist if it were not for people who do not accept the simplicity of base reality and can operate at higher levels at times with the help of LSD/Shrooms.
its funny how one may equate "harmful addiction" with the USE of such substance.... in fact, my counter-culture DNA has shown me my entire life - that "the establishment" literally is quelling human growth because of the fact that using these reveals the fragility and tenuous control they actually have.
In fact, I am sitting here with a book that one of my best friends just sent me - "The Fabric of Reality" (by David Deutsch) and in all likelihood, this evening you will be using tech that he has helped build...
The only thing that is "too good to be true" is when someone else tells you definitively that you must do and act "this way" because we said so. (Look at the fucking state of the world at this moment -- you think that all these governments and institutions know what the fuck they are talking about? - no...)
Go microdose some shrooms for good measure.
It feels like in the last few years I have been constantly hearing about new research showing “fun” drugs as cures to a wide array of medical conditions. There’s marijuana for chronic pain, mushrooms for depression, mdma for ptsd, and now ketamine. They are often talked about as if they have little or no harmful side effects. I’m glad we are moving away from the incredibly destructive drug policies that have been in…
One danger of chronic ketamine use is bladder damage.
I think a big part of the issue is that you quickly develop a tolerance to Ketamine, so if you're a daily user, there's a strong tendency to up the dosage to maintain its effect. If you're a casual user or are careful to spread it out to avoid tolerance buildup, I think it can be avoided.
With that said, you're absolutely right that it is a danger that needs to be kept in mind, but from what I've read, if you're not abusing it, the risk seems low.
It feels like in the last few years I have been constantly hearing about new research showing “fun” drugs as cures to a wide array of medical conditions. There’s marijuana for chronic pain, mushrooms for depression, mdma for ptsd, and now ketamine. They are often talked about as if they have little or no harmful side effects. I’m glad we are moving away from the incredibly destructive drug policies that have been in…
That's not true. The new idea was that a manageable addiction was preferred to chronic pain. The theory was that addiction to opioids could be managed. That turned out to be not the case. People started selling pills and buying street heroin and it spiraled out of control.