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Ivermectin Systematic Study: Inconclusive

cochranelibrary.com

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Re: Ivermectin Systematic Study: Inconclusive

#2
Two family members are physicians.. they've seen just an astounding number of people sick with Covid who picked up some horse dewormer at the local Tractor Supply Co. to "treat" or "prevent" their illness. It obviously didn't work for them since they ended up in the hospital... these are very commonly the same people who won't get vaccines since they're unproven. Worms in the brain actually might be a decent diagnosis.

Re: Ivermectin Systematic Study: Inconclusive

#3
The paper's actual headline is different than the one on the submitted link. (And I'm not sure it accurately reflects the last line of this paper.)

"Overall, the reliable evidence available does not support the use ivermectin for treatment or prevention of COVID‐19 outside of well‐designed randomized trials."

Re: Ivermectin Systematic Study: Inconclusive

#4
Other studies, with a larger sample of studies, found a moderate certainty of effect even when controlling for a study which later removed.

https://journals.lww.com/americantherapeutics/fulltext/2021/...

Another study from Queen Mary University also found certainty of effect

https://www.researchgate.net/publication/353195913_Bayesian_...

Study in Asian Pacific Journal of Tropical Medicine shows certainty of effect.

https://www.apjtm.org/article.asp?issn=1995-7645;year=2021;v...

I could go on. To really understand what is happening in relation to Ivermectin I can highly recommend Ben Goldacres book Bad Pharma..it shows in detail exactly what we are seeing happen with ivermectin.

There is a significant financial interest in having ivermectin perceived as ineffective. Firstly, if it works it makes the emergency use authorisation for the vaccines look quite precarious. Secondly, and probably more likely, there are novel therapies being developed for Covid right now. Nasal sprays. Anti virals.

They are patented. Ivermectin is not - it's post patent and can be manufacured by multiple companies. Merck who manufacture ivermectin themselves have a new anti viral they hope to bring to market.

If ivermectin - a $3 treatment - proves to be effective then the emergency use Authorization for novel Covid therapies goes out the window.

When we are looking at meta analysis that take about 20% of the available studies and conclude 'inconclusive' we should be mindful that there's a massive financial interest for this. Science works. But like everything else, if you influence how science is funded you influence the results it finds.

The cat is out of the bag on ivermectin. Its already being used in india (where I am) and where the second wave was brought under control without vaccines. There was just 5% vaccine penetration at the peak of second wave but ivermectin started to get administered at that time in delhi.

You'll hear more about the mega doses of horse paste. Its in super high concentration since....it's for horses. In the UK it's not even imported in tablet 12mg form. Hence the stupid situation in which people desperately try to get it via vets and the dosage is way out.

At 12mg doses it's very well tolerated. I should know since I use it india the moment I feel I have any symptoms. 18 months and so far so good. I am just one person of course but I know many many others who have been prescribed it when they got sick and they then recovered.

Science works but financial interests influence what does and does not publish.

Re: Ivermectin Systematic Study: Inconclusive

#5

The paper's actual headline is different than the one on the submitted link. (And I'm not sure it accurately reflects the last line of this paper.) "Overall, the reliable evidence available does not support the use ivermectin for treatment or prevention of COVID‐19 outside of well‐designed randomized trials."

Another quote from this paper:

"Ivermectin showed no evidence of an effect on increasing or decreasing mortality at 28 days, the most important outcome during this pandemic, neither in inpatients (two studies), outpatients (two studies), or the preventive setting (one study). The certainty for this finding was very low. The same accounts for clinical worsening up to 28 days in an inpatient setting and up to 14 days in an outpatient setting."

Re: Ivermectin Systematic Study: Inconclusive

#6

Other studies, with a larger sample of studies, found a moderate certainty of effect even when controlling for a study which later removed. https://journals.lww.com/americantherapeutics/fulltext/2021/... Another study from Queen Mary University also found certainty of effect https://www.researchgate.net/publication/353195913_Bayesian_... Study in Asian Pacific Journal of Tropical Medicine shows certainty of effect. h…

The study at that link includes Elgazzar's "retracted" results (which appear to have been fabricated).

https://www.theguardian.com/science/2021/jul/16/huge-study-s...

Re: Ivermectin Systematic Study: Inconclusive

#8
For some balance --

[1]excerpts from abstract

" Background: Repurposed medicines may have a role against the SARS-CoV-2 virus. The antiparasitic ivermectin, with antiviral and anti-inflammatory properties, has now been tested in numerous clinical trials."

" Conclusions: Moderate-certainty evidence finds that large reductions in COVID-19 deaths are possible using ivermectin. Using ivermectin early in the clinical course may reduce numbers progressing to severe disease. The apparent safety and low cost suggest that ivermectin is likely to have a significant impact on the SARS-CoV-2 pandemic globally. "

[1] https://journals.lww.com/americantherapeutics/fulltext/2021/...

-- Referenced in below article

https://www.jpost.com/health-science/israeli-scientist-says-...

--Also related

https://www.wsj.com/articles/fda-ivermectin-covid-19-coronav...

( bypass paywall -- https://twitter.com/westmeeteast/status/1420470317005352964 )

Re: Ivermectin Systematic Study: Inconclusive

#9

Two family members are physicians.. they've seen just an astounding number of people sick with Covid who picked up some horse dewormer at the local Tractor Supply Co. to "treat" or "prevent" their illness. It obviously didn't work for them since they ended up in the hospital... these are very commonly the same people who won't get vaccines since they're unproven. Worms in the brain actually might be a decent diagnosi…

Yesterday in a local paper they featured a front-page story about some dipshit who won't get vaccinated, refuses to wear a mask, and is covered in tattoos from his jaw to his ankles. The rate of severe reactions to tattooing (amputations and whatnot) is 2 in 10000.

Re: Ivermectin Systematic Study: Inconclusive

#10
I posted this previously but HN moderated my personal story. —> Story of how I came close to losing my life and how Ivermectin saved me. Ivermectin just saved my life. I woke up with thick mucous and blood that I couldn’t extricate or cough up and called my doctor and the hospital. They threw up their hands and said there is nothing we can do, monitor your saturation levels and let us know if you feel faint. And within 8 hours I could not walk or talk, my wife called the hospital and they said I need to be brought into ER. A friend of ours who was taking prophylactic treatment with Ivermectin brought in his medication and begged us not to go ER and wait for 6 more hours. I was put in touch with one of FLCCC doctors who immediately asked me to take Ivermectin and prescribed a steroid to ease my respiratory issue. 6 hours has passed, the symptoms started to stabilize and reverse. I was able to talk, walk and drink. Within 10 hours my saturation levels turned around. I still continued the protocol for the next 2 days, I was out of the woods with barely a sore throat. Continued the protocol and even the sore throat was gone. I am as good as new. My PCP is dumbfounded and refuses to acknowledge the work of ivermectin.
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