I've been working remote for about 10 years. I've had "real" offices. I've worked in open-plan offices. I've had a home office. I've worked from bed. There are tons of good ways to do it. Lately I swap between a kitchen table and a chair on my porch. I no longer use multiple screens, I've just gotten really fast at swapping windows on my 15" laptop; I've gotten good at figuring out how wide my terminal window breaks…
Having the right setup is not only about making your brain more productive - it's about keeping your spine pain free. While my home office is set up for this purpose, only one company that I have worked with so far had this aspect in mind. In the past, I had to take days off because of terrible set ups and long work hours. Having a well positioned and large second monitor helps a lot.
You have much more control over this while designing your home office. Working from bed is not the way unless you're planning to marry a physiotherapist in the future.