France issues moratorium on prion research after fatal brain disease strikes
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Re: France issues moratorium on prion research after fatal brain disease strikes
#302Hm: "long period of uncertainty began on 31 May 2010, when she stabbed her left thumb with a curved forceps while cleaning a cryostat—a machine that can cut tissues at very low temperatures—that she used to slice brain sections from transgenic mice infected with a sheep-adapted form of BSE . She pierced two layers of latex gloves and drew blood" Later in the article: ""We conduct research only on mouse-adapted sheep…
Keep in mind that the researcher was only 23 years old at the time when the lab accident happened. In some ways, she was basically a kid. As everyone knows, she ended up dying because of this. A human has a fully developed adult brain around age 25, but for some people it is not until age 30 [1]. [1] https://bigthink.com/mind-brain/adult-brain?rebelltitem=1#re...
Re: France issues moratorium on prion research after fatal brain disease strikes
#303Earlier quoted context omitted.
Prions aren't airborne. vCJD and mad cow spread by a feedback loop involving slaughtered infected animal brains being fed to the same animal stock. This case was a technician who stabbed herself with a tool heavily coated in brain matter from infected animals. It's not like a virus where just a few particles is enough to bootstrap an infection. At least, it's never been seen.
Prions can be airborne. > "Common knowledge is that prions aren't airborne, and can't cause infection that way," said neuropathologist Adriano Aguzzi of University Hospital Zurich, co-author of a study appearing today in PLoS Pathogens. "We were totally surprised and also a bit frightened at how efficient [airborne infections] were." https://www.wired.com/2011/01/airborne-prions-disease/
Re: France issues moratorium on prion research after fatal brain disease strikes
#304Earlier quoted context omitted.
Don't prions reproduce by re-folding other proteins to match themselves?
they dont replicate.
https://en.wikipedia.org/wiki/Prion#Prion_replication
There is a complex dependence on forming fibres that makes them slow (long lead time to symptoms) and then fast (dead soon after getting sick).
Re: France issues moratorium on prion research after fatal brain disease strikes
#305Earlier quoted context omitted.
I think this article, or another, said that probably applying disinfectant immediately would've been enough.
Prions are not affected by disinfectant
"The thumb should have been soaked in a bleach solution immediately, which did not happen, [the family's lawyer] adds"