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Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln, sees need for boosters

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Re: Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln, sees need for boosters

#31

Post by lmilcin »

RONROC wrote: post #22
ohmyblock wrote: post #2

Pfizer shouldn't be allowed to state publicly their opinion on this. Huge conflict of interests

It’s incredible that we even have to state that. This leaves a bad taste in my mouth, full stop. I got the vaccine, and am shocked that I may need to comply with another dose or “booster” shots. I’m trying my hardest to be a team player but I’m incredibly concerned that one side would be OK with “Life-Saving-Vacinne-as-a-Service” for the low cost of x$ per month, for an unknown amount of time, and the other side is c…

> It’s incredible that we even have to state that. This leaves a bad taste in my mouth, full stop.

How is that bad?

When you go to a car dealer, you know he has an incentive to sell to you.

Is it bad? No, it just is.

It doesn't mean you stop listening to him. You just filter the information to get what you need to make up your own decision.

If you distrust the dealer you can go to another dealer but you can also still work with him and maybe bring your own expert, which is popular practice.

In the end you need to buy a car and you can pretty much assume ALL dealers have the same incentive to sell to you.

Re: Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln, sees need for boosters

#32

Post by beebmam »

standardUser wrote: post #20
superkuh wrote: post #5

It's obvious we need booster vaccinations. But not another intramuscular that only seeps in serum IgG antibodies into the lower lungs. The levels of antibodies in the upper respiratory mucosa are never very high and drop rapidly. Viral infection of the mucosa and shedding still occurs. We need operation warp speed type money for funding the two good intranasal sars-cov-2 vaccine trials going on right now and to start…

It is not obvious we need booster vaccinations. There's simply not enough data yet to call this "obvious". Even "likely" is a stretch. Time will tell how long effective immunity lasts, but we absolutely do not know that number yet. EDIT: To be fair, it is at least likely that high-risk individuals may need boosters. Israel is already distributing them. But the idea that we will need an annual COVID shot, or that most…

That's correct, so far. It appears that humans who have been vaccinated with an mRNA vaccine still have a strong immune response to Delta variant. In fact, far better of an immune response than people who were infected with a previous variant.

Source is MedCram, easily the best source of medical information on YouTube, specifically at 7:05: https://www.youtube.com/watch?v=5RWGh19yTXw

Re: Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln, sees need for boosters

#33

Post by nicoburns »

standardUser wrote: post #20
superkuh wrote: post #5

It's obvious we need booster vaccinations. But not another intramuscular that only seeps in serum IgG antibodies into the lower lungs. The levels of antibodies in the upper respiratory mucosa are never very high and drop rapidly. Viral infection of the mucosa and shedding still occurs. We need operation warp speed type money for funding the two good intranasal sars-cov-2 vaccine trials going on right now and to start…

It is not obvious we need booster vaccinations. There's simply not enough data yet to call this "obvious". Even "likely" is a stretch. Time will tell how long effective immunity lasts, but we absolutely do not know that number yet. EDIT: To be fair, it is at least likely that high-risk individuals may need boosters. Israel is already distributing them. But the idea that we will need an annual COVID shot, or that most…

Effective immunity against current variants isn't too likely to be an issue, but new variants that circumvent that immunity seem pretty likely to me seeing as we're already seeing this to some extent with the Delta variant and we're nowhere near suppressing case levels to the point that we'd slow new variants from emerging.

Re: Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln, sees need for boosters

#34

Post by lmilcin »

loceng wrote: post #27
lmilcin wrote: post #12

Earlier quoted context omitted.

I fully disagree. This is important topic and they definitely have first hand expert knowledge. It is up to us (meaning our governments) to require proper documentation for this and make our own minds based on it.

And is government currently competent in even knowing what proper documentation looks like? Waiting for anyone competent to confirm or correct this person re: CDC's potentially wholly flawed math: https://roundingtheearth.substack.com/p/defining-away-vaccin...

If you are incompetent buyer that is kind of your problem. Governments don't have "buyer protection".

But, typically, governments have armies of people at their disposal and some of these people are experts that can read and understand documentation.

Demand your government to be accountable to find right people to do the right job of checking that documentation provided by Pfizer.

It would seem prudent to do this before you sign a contract for another couple billion dollars.

Re: Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln, sees need for boosters

#35

Post by clairity »

Panther34543 wrote: post #11

In summary: A.) Pfizer is raking in over $33 billion from vaccine sales. B.) Due to the PREP Act, they are completely immune from lawsuits arising from any form of complications arising from those vaccines. C.) If you don't take this vaccine, you may lose your job[0]. D.) If you don't take this vaccine, you may be barred from normal everyday social activities[1][2]. I can't be the only one who is incredibly uncomfort…

> "I can't be the only one who is incredibly uncomfortable about society going down this path."

it's dystopian. this is power that won't be reliquished by either major party, just like 9/11 surveillance and security theater. unlike some of currently fashionable political impetuses, this one is worth actively resisting, to keep federal powers in check.

Re: Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln, sees need for boosters

#36

Post by tdhz77 »

standardUser wrote: post #20
superkuh wrote: post #5

It's obvious we need booster vaccinations. But not another intramuscular that only seeps in serum IgG antibodies into the lower lungs. The levels of antibodies in the upper respiratory mucosa are never very high and drop rapidly. Viral infection of the mucosa and shedding still occurs. We need operation warp speed type money for funding the two good intranasal sars-cov-2 vaccine trials going on right now and to start…

It is not obvious we need booster vaccinations. There's simply not enough data yet to call this "obvious". Even "likely" is a stretch. Time will tell how long effective immunity lasts, but we absolutely do not know that number yet. EDIT: To be fair, it is at least likely that high-risk individuals may need boosters. Israel is already distributing them. But the idea that we will need an annual COVID shot, or that most…

Big pharma is pushing for boosters before the science.

I’m happy that even Congress was skeptical of the claim in the last covid congressional committee discussion.

Re: Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln, sees need for boosters

#37

Post by mint2 »

Panther34543 wrote: post #11

In summary: A.) Pfizer is raking in over $33 billion from vaccine sales. B.) Due to the PREP Act, they are completely immune from lawsuits arising from any form of complications arising from those vaccines. C.) If you don't take this vaccine, you may lose your job[0]. D.) If you don't take this vaccine, you may be barred from normal everyday social activities[1][2]. I can't be the only one who is incredibly uncomfort…

Given that:

A. Pfizer isn’t the only vaccine option.

B. If one doesn’t take the vaccine, one’s chances of dying or being disabled for years or permanently are much higher.

C. If one doesn’t take the vaccine there is a significant chance they give the virus to someone else, killing them.

I think it’s the best option out of all non-great options to mandate vaccines in order to participate in crowded settings. It’s a matter of civic responsibility in order to partake in civic life. Sure it would be better if there was no Covid so no one would need an extra vaccine, but that world no longer exists. I don’t like the current situation either but it is what it is.

Civic responsibility isn’t brought up much these days. Liability shield for vaccine makers isn’t fair, but unvaccinated allowed to romp around spreading the virus without liability is also not fair.

Re: Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln, sees need for boosters

#38

Post by notheretoo »

beachy wrote: post #17

Anti-vaxxers are setting the stage for enormous profits for big pharma by creating the conditions for breeding new variants that will require more big pharma to combat them. I feel my grandkids will grow up in a world quite different from mine, where travel and experiences will be gated and limited by fear of contagious disease. That sucks and didn't need to happen. Thought experiment for anti-vaxxers - what if there…

You’re right - this gated world didn’t need to happen. Sure would have been nice if American scenarists and eco health didn’t continue gain of function research after it was outlawed in the us.

So uh what about this?

https://wwwnc.cdc.gov/eid/article/27/10/21-1427_article

If it’s true the vax causes antibody dependent enhancement and that YOU, as the individual who took the experimental therapy, is producing higher viral loads would you take your punishment if you where responsible for thousands of deaths?

Also - what do we call people who are currently vaccinating their children yet refuse the experimental therapy? Clearly they’re not antivaxxers.

Re: Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln, sees need for boosters

#39

Post by programmarchy »

beachy wrote: post #17

Anti-vaxxers are setting the stage for enormous profits for big pharma by creating the conditions for breeding new variants that will require more big pharma to combat them. I feel my grandkids will grow up in a world quite different from mine, where travel and experiences will be gated and limited by fear of contagious disease. That sucks and didn't need to happen. Thought experiment for anti-vaxxers - what if there…

Leaky vaccines, like ones like the ones we have for COVID, also put evolutionary pressure on viruses. Anti-vaxxers are a convenient scapegoat, but the problem isn't that simple.

Re: Pfizer says 2021 Covid-19 vaccine sales to top $33.5 bln, sees need for boosters

#40

Post by tylerhou »

gowld wrote: post #19
swader999 wrote: post #9

Party might be ending for Pfizer if this early report plays out as stated and data shows viral blood titers are being found to have higher loads in the vaccinated vs non vaxxed. It would suggest the worst nightmare for a vaccine, ADE could be happening. From NBC Twitter: New data suggests that fully vaccinated individuals are not just contracting COVID, but could be carrying higher levels of virus than previously und…

What does it mean to compare "loads" of "viral titers"? What is ADE? How does this square with the fact that the disease is making non-vaccinated people far more ill at far higher rates than vaccinated? The tweet says that vaccinated folks "could be carrying higher levels of virus than previously understood", not higher levels than unvaccinated individuals.

I'm not a biologist, so this is my rough understanding.

ADE is antibody-dependent enhancement, a phenomenon that could occur when your body is exposed to a virus for a second time. Normally, your body has developed antibodies and therefore can fight off the virus easily. However, if the second infection is a different serotype, then (in rare cases) the body's antibodies might actually help the second virus infect your body's cells and cause worse disease. Or, they don't properly neutralize the virus (and your body might not develop new antibodies). This has happened in the past with previous vaccines [1].

We know that ADE is a risk; therefore, we specifically designed Covid animal trials to look for ADE events [2]. Also, we monitored for ADE events during human trials. There hasn't been a single confirmed case of ADE to my knowledge. That hasn't stopped antivaxxers from using ADE fears to claim that the currently approved Covid vaccines aren't safe.

[1] https://www.chop.edu/centers-programs/vaccine-education-cent...

[2] https://blogs.sciencemag.org/pipeline/archives/2021/02/12/an...

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