151–160 of 162 posts
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I second your thought. For sure, I am smarter and wiser then I was in my 20s, which wasn't long ago. But I am also carrying baggage of the past with me, which in some case makes less wise and less brave than I wanted to be.
> There's a heluva lot I wish I could tell my 20 year old self. Like?
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Imagine going to school for 50 years? You're still a child at 100? Imagine being able to use compounding interest for a hundred years before you start work. I do not think we can approach this world with our current perceptions.
The biggest concern I have is that with current societal expectations an infinite life span would mean working for thousands of years for someone else with little to no retirement phase of life. Effectively, infinite slavery. No, we require major societal change for this to be attractive. Regards compounding interest, the economic markets have a basis in reality and so can't keep compounding forever. Also even if it…
I’m really sick of people equating working for someone else with slavery.
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David Sinclair is an expert on this and has said otherwise. Clinical trials are expensive. To fund them you need billions of dollars. Pharmas won’t fund research in anti-aging directly because it’s not considered a disease, can’t get FDA approval, and thus couldn’t be sold. So, yes, you need to find another route to approval, similar to metformin and rapamycin.
One thing I've never understood, given that trials are so insanely expensive, is why healthcare companies with billions of dollars don't open up "offshore" research facilities to do trials in more lax jurisdictions. I've done none of the research, just imagining, but if you were to open up a compound in Somalia or somewhere, make the appropriate political contributions, would you really be bogged down with lots of re…
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One thing I've never understood, given that trials are so insanely expensive, is why healthcare companies with billions of dollars don't open up "offshore" research facilities to do trials in more lax jurisdictions. I've done none of the research, just imagining, but if you were to open up a compound in Somalia or somewhere, make the appropriate political contributions, would you really be bogged down with lots of re…
So, experiment on poor black people? I think you are on the wrong forum.
I think it's a bit racist for you to generalize my description of a poor and under regulated state, like Somalia, as being equal to "black people". Not all countries in Africa are like Somalia, you know. I suggest reading a bit more about Africa. I personally enjoy watching YouTube videos made by creators in different countries, African countries have a wide range.
As Mark Twain said, "Travel is fatal to prejudice". Today, we can virtually "travel" with the click of a button. Not all black people are poor Somalis!
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So, experiment on poor black people? I think you are on the wrong forum.
The necessary part is only that the prospective subjects aren't protected by strict regulatory regimes like in the United States. Somalia, as, essentially, a failed state, I assume, has lax medical regulations and is a possible candidate for experimentation. I think it's a bit racist for you to generalize my description of a poor and under regulated state, like Somalia, as being equal to "black people". Not all count…
https://en.m.wikipedia.org/wiki/Medical_experimentation_in_A...
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When I did construction, many conversations were about the generous retirement benefits. It was always, "When I retiree I will be able to do this, and that, in comfort." There was always the big decision of shouid I retire at 25 years (25 year old working 25 years), or get a few hundred more if I wait until 65? I knew a person who worked accounting at the union. She told me the average retire whom waits for the bigge…
Anecdotally similar happened to my step-father. He was working extra shifts, overtime etc. Died 6months before full pension. He never cashed a single check and my mom only got about 1/2 of what the full pension would have been worth (discounted value) because he passed "before retirement" . This is part of why I'm so adamant that I think pensions and the like are scams. I want to run my portfolio and my next of kin c…
It would be nice if companies paid more into the 401k though, and didn't necessarily require the match. The 401k system is also letting companies off the hook with measly amounts. I'm mostly thinking about the people working at places like Lowe's and Walmart making $10-15/hr. Even 4% of $30k is only $1200 per year. Some of the people I knew who were working there were only contributing 1-2% (so 2-4% total with the match) because they couldn't afford to contribute more.
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Climate change is also going to make the world increasingly less pleasant to live in over the next couple decades, directly (weather, flooding, drought, famine, etc) and indirectly (instability, social unrest, war). Unless you can extend your life long enough (and otherwise have the means) to see the other side of this epoch, suffering through more of it is probably not desirable.
honest question, do you think this is true even for middle class or wealthier people from wealthy nations? I imagine we have the resources to just move and adapt. The way I understood it it's the poor nations that are really screwed. They cannot afford to relocate, and some of them have the worst weather already (feeding into why they're already poor).. .
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David Sinclair is an expert on this and has said otherwise. Clinical trials are expensive. To fund them you need billions of dollars. Pharmas won’t fund research in anti-aging directly because it’s not considered a disease, can’t get FDA approval, and thus couldn’t be sold. So, yes, you need to find another route to approval, similar to metformin and rapamycin.
One thing I've never understood, given that trials are so insanely expensive, is why healthcare companies with billions of dollars don't open up "offshore" research facilities to do trials in more lax jurisdictions. I've done none of the research, just imagining, but if you were to open up a compound in Somalia or somewhere, make the appropriate political contributions, would you really be bogged down with lots of re…
Earlier quoted context omitted.
honest question, do you think this is true even for middle class or wealthier people from wealthy nations? I imagine we have the resources to just move and adapt. The way I understood it it's the poor nations that are really screwed. They cannot afford to relocate, and some of them have the worst weather already (feeding into why they're already poor).. .
Sure, the wealthy will be able to move and adapt, consuming an increasingly large share of the dwindling resources to maintain their comfortable lifestyle. Meanwhile the poor and then the middle class will be left to fend for themselves, or stuffed into refugee camps in marginally habitable areas.
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That would require them to be a small minority, which the OP is suggesting would be the opposite of the case.
I guess it depends on the validity of the arguments put forth in Ernest Becker's The Denial of Death . The important distinction between longevity and the situation surrounding the pandemic is not the rejection of a benefit, but the construction of a fantasy that allows the rejection of the benefit by re-framing it as a detriment. The pandemic itself is recast as 'not that bad' or a 'falsification', further removing…
To me, that is not very appealing... Living a healthier live at my 60s and 70s, and be able to be rock climbing with my grandsons and daughters definitely is... Most probably that will translate to longer life expectancy, but I don't think that by itself should be the goal.