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SARS-CoV-2 Gamma variant infected 16 fully Pfizer vaccinated Guiana gold miners

wwwnc.cdc.gov

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Re: SARS-CoV-2 Gamma variant infected 16 fully Pfizer vaccinated Guiana gold miners

#41

Post by dv_dt »

sterlind wrote: post #13
refurb wrote: post #4

Fully vaccinated individuals getting infected shouldn't be all that surprising. The phase 3 trials of Pfizer and Moderna saw a 95% reduction in severe symptoms. No routine testing for infection was done, only testing if someone showed symptoms. Singapore's gov't is tracking all of their infections and 80% of the population has had 1 shot, 50% fully vaccinated (Pfizer and Moderna). They've had 1096 cases in the last 2…

I feel like a 60% attack rate among fully vaccinated people in one outbreak is pretty chilling, though. Like I'm glad they didn't have severe illness but this news is disappointing. Delta seems to heavily dominate in Singapore [0], and they don't seem to have Gamma at all. The outbreak in this article was Gamma. This study doesn't jive well with the in-vitro tests of vaccinated serum against gamma and the numbers we'…

The guinea study does list one possibility that the working conditions of the miners sharing machine cabs could have contributed to the case too.

Re: SARS-CoV-2 Gamma variant infected 16 fully Pfizer vaccinated Guiana gold miners

#42

Post by MeinBlutIstBlau »

dopylitty wrote: post #5
dgant wrote: post #3

"No clinically severe COVID-19 (1) was observed, and no patient was hospitalized" In other words, this case study is a relatively ordinary result in line with what we know: that the major COVID-19 vaccines greatly reduce the chance of severe illness but leave nontrivial chance of infection and transmission.

It’s worth noting that the bar for severe illness is set incredibly high. [1] All of the major symptoms including high fever, cough, severe fatigue, loss of taste/smell, and shortness of breath still count as mild under their definition. This is very much a disease you don’t want to get, even the so called mild version that happens in vaccinated people. 1. https://www.covid19treatmentguidelines.nih.gov/overview/clin.…

I had COVID before the lockdowns. It wasn't apparent to me until I started hearing about the symptoms. The fatigue was awful, but on top of that, the night my fever broke I was laying down on my bed during February with a window open and no sheets covering me. All while hyperventilating. I kinda thought this was a weird flu but fortunately I didn't have to worry up front about potential death while having it. Worst case scenario I just wouldn't have woken up.

Re: SARS-CoV-2 Gamma variant infected 16 fully Pfizer vaccinated Guiana gold miners

#43

Post by lugged »

kadoban wrote: post #28
lugged wrote: post #9

Earlier quoted context omitted.

Sure if you don't think permanent social distancing and mask wearing is not a problem. The severity of mild covid is still potentially long lasting and I'm willing to guess elderly aren't going to handle it well. Letting covid become endemic could reduce our life expecty considerably.

Isn't covid already endemic?

Some claim it can still be irradicated. But those people get banned on YouTube for saying bad words so you probably won't believe me.

Re: SARS-CoV-2 Gamma variant infected 16 fully Pfizer vaccinated Guiana gold miners

#44

Post by refurb »

sterlind wrote: post #40
refurb wrote: post #30

Earlier quoted context omitted.

I wouldn't read too much into the 50% being fully vaccinated. Front-line workers (both medical and retail) are most likely to be exposed versus someone unvaccinated. In addition, as vaccination rates go up, you'd expect to see more fully vaccinated people test positive since there are so few unvaccinated people. Not sure why I got downvoted - this is exactly what we expected - the vaccine protects against serious dis…

60% of the gold miners that were fully vaccinated at this jobsite got infected and became mild to moderately ill. that's why this is interesting - it's a case study of vaccine effectiveness among a bunch of people exposed to one variant in one place.

I got my wires crossed, I thought OP was talking about Singapore where ~50% of those infected were fully vaccinated.

Yes, you are correct that the miners are a defined population, all exposed to one variant in one place. It would suggest that the Singapore numbers aren't skewed that much by front-line workers being vaccinated at a higher rate.

Re: SARS-CoV-2 Gamma variant infected 16 fully Pfizer vaccinated Guiana gold miners

#45

Post by spoonjim »

dopylitty wrote: post #11
version_five wrote: post #7

Earlier quoted context omitted.

> Severe Illness: Individuals who have SpO2 30 breaths/min, or lung infiltrates >50%. Isn't the point that levels below severe are not generally fatal and don't require hospitalization. Nobody thinks it's good to get sick, but it generally ceases to be a threat to public health with vaccination.

That may be but it’s not a particularly useful definition on an individual level. If I’m sick in bed for two weeks I can’t work or take care of my family so those mild symptoms very much would be a danger, not to mention the dangers from long COVID which hasn’t been ruled out in vaccinated folks and the dangers of exposing people who can’t be vaccinated.

It’s very useful on the individual level. All that sounds bad but not as bad as dying.

Re: SARS-CoV-2 Gamma variant infected 16 fully Pfizer vaccinated Guiana gold miners

#46

Post by throwawayboise »

YZF wrote: post #38
wyldfire wrote: post #37

Earlier quoted context omitted.

IIRC pathogenicity has an inverse relationship with virulence.

There are no hard rules here. The UK variant is supposedly both more severe and more infectious ( https://www.bmj.com/content/372/bmj.n579 ). The common wisdom there is that something that kills you faster has less chance to transmit but there's nothing precluding something that kills you slowly and is very infectious while it does that.

Yes, Ebola is quite contageous but kills so fast it tends to burn out and not spread.

AIDS kills you slowly and is infectious while it does that, so it spreads widely.

Re: SARS-CoV-2 Gamma variant infected 16 fully Pfizer vaccinated Guiana gold miners

#47

Post by seventytwo »

kaczordon wrote: post #14
wussboy wrote: post #8

Earlier quoted context omitted.

That is an incredible leap.

Nope, globally we know that re-infection rarely occurs after being infected. This study shows a 60% attack rate for fully vaccinated miners, which is horrendous. The whole point of this study is that vaccination does not stop transmission of the virus. To quote the study: In conclusion, we describe a VOC Gamma COVID-19 outbreak with a strikingly high attack rate among persons fully vaccinated with BNT162b2 vaccine.[……

Are you making a point? Or just trying to be a pedant?

Re: SARS-CoV-2 Gamma variant infected 16 fully Pfizer vaccinated Guiana gold miners

#48

Post by seventytwo »

flybrand wrote: post #27

“Attack rate was 0/6 among persons with a previous history of COVID-19 versus 63.2% among those with no previous history (Table).”

… and 99% of cases in the US are among the unvaccinated.

What’s your point?

Re: SARS-CoV-2 Gamma variant infected 16 fully Pfizer vaccinated Guiana gold miners

#49

Post by kadoban »

lugged wrote: post #43
kadoban wrote: post #28

Earlier quoted context omitted.

Isn't covid already endemic?

Some claim it can still be irradicated. But those people get banned on YouTube for saying bad words so you probably won't believe me.

Do they say how? Doesn't seem like it even makes sense anymore. I'm going to guess based on your youtube wording that their answer is not vaccines?

Re: SARS-CoV-2 Gamma variant infected 16 fully Pfizer vaccinated Guiana gold miners

#50

Post by seventytwo »

standapart wrote: post #18

The main takeaway here, mentioned above, is that this might throw shade on the "public good" idea of vaccination-- that you should still vaccinate those at minimal risk from Covid. If you're at high risk, you should definitely still get vaccinated. Maybe just stop telling twenty-somethings they should get vaccinated too.

No, you’re completely wrong. This throws no shade on vaccinations whatsoever.
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