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SARS-CoV-2 Gamma variant infected 16 fully Pfizer vaccinated Guiana gold miners

wwwnc.cdc.gov

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Re: SARS-CoV-2 Gamma variant infected 16 fully Pfizer vaccinated Guiana gold miners

#31

Post by pbourke »

kaczordon wrote: post #14
wussboy wrote: post #8

Earlier quoted context omitted.

That is an incredible leap.

Nope, globally we know that re-infection rarely occurs after being infected. This study shows a 60% attack rate for fully vaccinated miners, which is horrendous. The whole point of this study is that vaccination does not stop transmission of the virus. To quote the study: In conclusion, we describe a VOC Gamma COVID-19 outbreak with a strikingly high attack rate among persons fully vaccinated with BNT162b2 vaccine.[……

We also know that confirmed cases are mainly among the unvaccinated and serious outcomes are nearly all (99%) among unvaccinated, despite fully vaccinated and unvaccinated being roughly equal populations in the US at present.

Re: SARS-CoV-2 Gamma variant infected 16 fully Pfizer vaccinated Guiana gold miners

#32

Post by gojomo »

kaczordon wrote: post #6
dgant wrote: post #3

"No clinically severe COVID-19 (1) was observed, and no patient was hospitalized" In other words, this case study is a relatively ordinary result in line with what we know: that the major COVID-19 vaccines greatly reduce the chance of severe illness but leave nontrivial chance of infection and transmission.

What’s more interesting is that 0/6 of the miners who had natural immunity were re-infected. That points to natural immunity preventing spread. The fact that vaccinated individuals don’t stop transmission means that there is no “public good” from getting vaccinated, it’s solely for personal benefit. Vaccine mandates or checking for vaccination status are pointless because of this.

It is interesting that none of the infection-recovered were infected - though with only 6 individuals, that could be luck. There have been other hints natural immunity is stronger versus later variants.

But your other point doesn't follow. The vaxed still tested positive at a slightly lower rate than the unvaxed. With no severe cases, no one died & no burden on limited emergency facilities was created.

There's not enough info to know how much the vaxed spread it to others; they conjecture that their "patient 40", an unvaxed individual who had an asymptomatic case, was the "index case" that brought the infection in. Especially in the conditions of a mine – which might have limited ventiliation – perhaps that one unvaxed person shedded enough infectious material to create all the subsequent infections.

Re: SARS-CoV-2 Gamma variant infected 16 fully Pfizer vaccinated Guiana gold miners

#33

Post by 8note »

Ostrogodsky wrote: post #17
dgant wrote: post #3

"No clinically severe COVID-19 (1) was observed, and no patient was hospitalized" In other words, this case study is a relatively ordinary result in line with what we know: that the major COVID-19 vaccines greatly reduce the chance of severe illness but leave nontrivial chance of infection and transmission.

I suppose those miners are strong healthy men, wouldnt we expect the same results if they were exposed to the virus while being not-vaccinated? > In other words, this case study is a relatively ordinary result in line with what we know: that the major COVID-19 vaccines greatly reduce the chance of severe illness but leave nontrivial chance of infection and transmission. I dont think this particular case is a proof of…

Depending on the mine, I'd guess miner is a prexisting condition in and of itself

Re: SARS-CoV-2 Gamma variant infected 16 fully Pfizer vaccinated Guiana gold miners

#35

Post by yalogin »

kaczordon wrote: post #6
dgant wrote: post #3

"No clinically severe COVID-19 (1) was observed, and no patient was hospitalized" In other words, this case study is a relatively ordinary result in line with what we know: that the major COVID-19 vaccines greatly reduce the chance of severe illness but leave nontrivial chance of infection and transmission.

What’s more interesting is that 0/6 of the miners who had natural immunity were re-infected. That points to natural immunity preventing spread. The fact that vaccinated individuals don’t stop transmission means that there is no “public good” from getting vaccinated, it’s solely for personal benefit. Vaccine mandates or checking for vaccination status are pointless because of this.

Wow you were able to jump to a devastating conclusion with absolutely nothing.

Re: SARS-CoV-2 Gamma variant infected 16 fully Pfizer vaccinated Guiana gold miners

#36

Post by throwitaway1235 »

Does anyone know if their is a correlation between how contagious a variant is and how lethal it is?

For example, MERS has a 35% CFR but wasn't a global health disaster because it wasn't highly contagious. Same goes for Ebola, which is even more fatal but even less contagious.

My point/question - the more contagious a Covid-19 variant = lower CFR?

Re: SARS-CoV-2 Gamma variant infected 16 fully Pfizer vaccinated Guiana gold miners

#37

Post by wyldfire »

throwitaway1235 wrote: post #36

Does anyone know if their is a correlation between how contagious a variant is and how lethal it is? For example, MERS has a 35% CFR but wasn't a global health disaster because it wasn't highly contagious. Same goes for Ebola, which is even more fatal but even less contagious. My point/question - the more contagious a Covid-19 variant = lower CFR?

IIRC pathogenicity has an inverse relationship with virulence.

Re: SARS-CoV-2 Gamma variant infected 16 fully Pfizer vaccinated Guiana gold miners

#38

Post by YZF »

wyldfire wrote: post #37
throwitaway1235 wrote: post #36

Does anyone know if their is a correlation between how contagious a variant is and how lethal it is? For example, MERS has a 35% CFR but wasn't a global health disaster because it wasn't highly contagious. Same goes for Ebola, which is even more fatal but even less contagious. My point/question - the more contagious a Covid-19 variant = lower CFR?

IIRC pathogenicity has an inverse relationship with virulence.

There are no hard rules here. The UK variant is supposedly both more severe and more infectious ( https://www.bmj.com/content/372/bmj.n579 ). The common wisdom there is that something that kills you faster has less chance to transmit but there's nothing precluding something that kills you slowly and is very infectious while it does that.

Re: SARS-CoV-2 Gamma variant infected 16 fully Pfizer vaccinated Guiana gold miners

#39

Post by pixl97 »

throwawayboise wrote: post #24
Ostrogodsky wrote: post #23

Earlier quoted context omitted.

What is your point? You are not comparing against the general population to see if there is a difference. Also from the study: > Such a low vaccine efficiency against infection by the Gamma variant was not expected because in vitro studies have shown a similar reduction of neutralization for Beta or Gamma variants by BNT162b2-elicited antibodies (5) and a conserved CD4+ T-cell response against spike proteins from the…

It was in response to "I suppose those miners are strong healthy men" They were not. They were obese and hypertensive. That is unhealty no matter what vaccines you take.

Well, isn't something like over half of America obese?

Re: SARS-CoV-2 Gamma variant infected 16 fully Pfizer vaccinated Guiana gold miners

#40

Post by sterlind »

refurb wrote: post #30
sterlind wrote: post #13

Earlier quoted context omitted.

I feel like a 60% attack rate among fully vaccinated people in one outbreak is pretty chilling, though. Like I'm glad they didn't have severe illness but this news is disappointing. Delta seems to heavily dominate in Singapore [0], and they don't seem to have Gamma at all. The outbreak in this article was Gamma. This study doesn't jive well with the in-vitro tests of vaccinated serum against gamma and the numbers we'…

I wouldn't read too much into the 50% being fully vaccinated. Front-line workers (both medical and retail) are most likely to be exposed versus someone unvaccinated. In addition, as vaccination rates go up, you'd expect to see more fully vaccinated people test positive since there are so few unvaccinated people. Not sure why I got downvoted - this is exactly what we expected - the vaccine protects against serious dis…

60% of the gold miners that were fully vaccinated at this jobsite got infected and became mild to moderately ill. that's why this is interesting - it's a case study of vaccine effectiveness among a bunch of people exposed to one variant in one place.
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