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Everything you need to know about Covid-19 vaccines

pharmaceutical-journal.com

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Re: Everything you need to know about Covid-19 vaccines

#61

Post by fsh »

kaskakokos wrote: post #34

This is the EudraVigilance web [1]: European database of suspected adverse drug reaction reports. On this website you can view data on suspected drugs side-effects, COVID vaccines included. This is the Med Alerts web [2]: The U.S. Government database incidents of adverse health events that follow the administration of a vaccine. [1] https://www.adrreports.eu/en/index.html [2] https://medalerts.org/vaersdb/findfield.p…

Pretty much any possible medical problem has a non-zero background rate in the population. When you vaccinate hundreds of millions of people, you probably sample all of those at least once. One needs to do a proper statistical analysis to determine if there is any causal link to the vaccination.

Re: Everything you need to know about Covid-19 vaccines

#62

Post by fsh »

drukenemo wrote: post #4
ggm wrote: post #2

Everything you need to know about Covid-19 vaccines Which can be found by the authors. But, for the ones we can't find any information which actually we're all fascinated in, like Sputnik or the Chinese vaccines, or the Cuban vaccine, bupkes. Oddly, nothing about Johnson & Johnson, the only single dose design I know about. Absence of information leads to presence of .. assumptions. Like, "they're all bad" which is fa…

I know I’m not addressing the article , but the comment above and many others on this topic. I’m still surprised by the blank check this community generally gives to big pharma and governments, seeing their track records. It’s not that I expect an anti (COVID-19) vaccine attitude, but I would have expected to see here a more questioning tone more regularly, as I see how strongly voiced HN can be with other topics. Fo…

All of these issues have been discussed extensively for months.

According to the mRNA vaccine data I've seen, for adults the benefit of protection against COVID-19 vastly outweighs any observed risks due to the vaccine. This was already the case after the very large phase-3 studies, and much more so after real-world data from hundreds of millions of vaccinations became available. So it should not be surprising that there is a broad consensus that getting the vaccine is a good idea.

Of course the initial studies excluded riskier groups such as pregnant women and children. Now there is some data, but no general consensus between the different countries' regulatory agencies yet.

Overall, I don't see a "blank check" for the pharma companies at all. They had to conduct and publish very large studies before getting even emergency use authorizations for their products.

Re: Everything you need to know about Covid-19 vaccines

#63

Post by kaskakokos »

fsh wrote: post #61
kaskakokos wrote: post #34

This is the EudraVigilance web [1]: European database of suspected adverse drug reaction reports. On this website you can view data on suspected drugs side-effects, COVID vaccines included. This is the Med Alerts web [2]: The U.S. Government database incidents of adverse health events that follow the administration of a vaccine. [1] https://www.adrreports.eu/en/index.html [2] https://medalerts.org/vaersdb/findfield.p…

Pretty much any possible medical problem has a non-zero background rate in the population. When you vaccinate hundreds of millions of people, you probably sample all of those at least once. One needs to do a proper statistical analysis to determine if there is any causal link to the vaccination.

I agree with you, and with all this uncertainty, does anyone know if:

Covid-associated problems > Vaccine-associated problems?

I imagine that this is not so easy, probably we can split the response by age, previous medical issues, etc. An also I am sure that Covid-associated problems (including dead) have been decreasing since it was first discovered in humans. So, which is the status?

Re: Everything you need to know about Covid-19 vaccines

#64

Post by kaskakokos »

Archelaos wrote: post #37

The title of the article completely devalues it in my eyes. How does the author know that the reader does not want to know something else? This seems to me to be a very paternalistic attitude. What is not discussed at all, for example, are cross-vaccinations with different vaccines, e.g. AstraZeneca + mRNA.

Agree. I need to know a lot of additional things about Covid. Indeed it seems to me like the article is quite superficial.

A lot of people here is doing smart questions that the article does not response.

Re: Everything you need to know about Covid-19 vaccines

#65

Post by fsh »

kaskakokos wrote: post #63
fsh wrote: post #61

Earlier quoted context omitted.

Pretty much any possible medical problem has a non-zero background rate in the population. When you vaccinate hundreds of millions of people, you probably sample all of those at least once. One needs to do a proper statistical analysis to determine if there is any causal link to the vaccination.

I agree with you, and with all this uncertainty, does anyone know if: Covid-associated problems > Vaccine-associated problems? I imagine that this is not so easy, probably we can split the response by age, previous medical issues, etc. An also I am sure that Covid-associated problems (including dead) have been decreasing since it was first discovered in humans. So, which is the status?

The clinical studies clearly show that the benefit from getting the vaccine outweighs the possible risks. Otherwise the regulatory agencies would not have approved them.

Why don't you simply look up the reports from the approval agency of your choice if you want to know the details?

Re: Everything you need to know about Covid-19 vaccines

#66

Post by kaskakokos »

fsh wrote: post #65
kaskakokos wrote: post #63

Earlier quoted context omitted.

I agree with you, and with all this uncertainty, does anyone know if: Covid-associated problems > Vaccine-associated problems? I imagine that this is not so easy, probably we can split the response by age, previous medical issues, etc. An also I am sure that Covid-associated problems (including dead) have been decreasing since it was first discovered in humans. So, which is the status?

The clinical studies clearly show that the benefit from getting the vaccine outweighs the possible risks. Otherwise the regulatory agencies would not have approved them. Why don't you simply look up the reports from the approval agency of your choice if you want to know the details?

I am not sure that this is accurate. For me it is like a coin:

- One side shows the benefits of the vaccine, and let's not forget that this side is promoted by the vaccine sellers. No problem with that, they do their job, in a few months we will see a 3rd and 4th dose being promoted to ensure immunity.

- The other side shows the cons of the vaccine, but as you said it is not sufficiently studied.

It seems to me insufficient to make decisions.

Re: Everything you need to know about Covid-19 vaccines

#67

Post by intev »

taxicabjesus wrote: post #36

Maybe you all can help me out. For someone who's not yet vaccinated, what's the point? 1. We now know that most of the carnage of February/March/April 2020 had to do with the aggressive use of ventilators. Once doctors stopped ventilating the majority of their patients, survival became the likely outcome of a SARS-CoV-2 infection. 2. We now know that severe COVID-19 is basically a Serotonin Syndrome (without the cust…

1) Do we know that? So all the doctors in Indonesia and India are currently killing 100,000s by begging for ventilators? Interesting.

2) Wait a minute. You are arriving at this conclusion based on a study of T-W-O people?

I'm not even going to bother with the rest of it because it's infuriating reading this. If you don't have a medical degree, I will completely disregard your few hours of research online. It's people like you who will make this take longer than necessary.

Re: Everything you need to know about Covid-19 vaccines

#68

Post by fsh »

kaskakokos wrote: post #66
fsh wrote: post #65

Earlier quoted context omitted.

The clinical studies clearly show that the benefit from getting the vaccine outweighs the possible risks. Otherwise the regulatory agencies would not have approved them. Why don't you simply look up the reports from the approval agency of your choice if you want to know the details?

I am not sure that this is accurate. For me it is like a coin: - One side shows the benefits of the vaccine, and let's not forget that this side is promoted by the vaccine sellers. No problem with that, they do their job, in a few months we will see a 3rd and 4th dose being promoted to ensure immunity. - The other side shows the cons of the vaccine, but as you said it is not sufficiently studied. It seems to me insuf…

This is not at all what I said!

Before conditional approval, possible risks have been extensively studied in very large phase 3 trials with a few ten thousand participants. For reference, the phase 3 study of the conventional TBE vaccine I recently got had just a few thousand participants. Like for any other medication, regulatory agencies have used this safety and efficacy data to judge whether the vaccine is beneficial or not. I strongly suggest you look up the corresponding reports for the various COVID-19 vaccines if you are interested in the details. Most countries' agencies post them publicly on their websites.

Due to the limited number of participants, is not possible to detect extremely rare side effects in a clinical trial. This is why most countries have adverse effect reporting systems. If they detect statistically significant anomalies (e.g. rare thromboses in vector vaccines), they then update their recommendations taking into account the new data. This is again standard procedure for all medications.

Re: Everything you need to know about Covid-19 vaccines

#69

Post by NiceWayToDoIT »

fsh wrote: post #60
NiceWayToDoIT wrote: post #42

Earlier quoted context omitted.

Interesting enough testes are ranging from £50-250 and usually u need few, even self-test kits have similar range. I wonder is there a way to have a really cheap tests (£3-5) ? I guess it would be interesting to find out PCR test cost break down.

Rapid antigen test kits have reached retail prices well below 1€ now. They probably cost cents to produce. I guess a significant factor in the cost of PCR tests are the thermocyclers and the lab staff. Not nearly as easy to scale as rapid test kits.

Cost of staff is understandable, but here self-kits are selling for £89 which looks greatly as exploit of unfortunate circumstances.

Re: Everything you need to know about Covid-19 vaccines

#70

Post by sofixa »

swader999 wrote: post #47
mindslight wrote: post #40

Earlier quoted context omitted.

What do you think Equifax, LexisNexis, criminal background checks, person-search websites, and automated account termination are? "Social credit" only seems like some foreign concept because it was coined describing a foreign society - it's more difficult to look inwards at what already exists.

You don't have to do those for day to day living, attending school, getting on a plane, most employment, entering a grocery store, a pub or daycare for your kid. These will have to be scanned to work and will be able to be turned off. USA seems to be slow rolling towards it but look at France and UK just this week. Life ending fines, 6 month jail time if you enter one of these places without it. No exemptions for tho…

> ut look at France and UK just this week. Life ending fines, 6 month jail time if you enter one of these places without it. No exemptions for those that aquired natural immunity either

You are wrong, you need a valid digital certificate which can come from 1) two doses and 14 days; 2) negative PCR less than 73hrs; 3) certificate you had covid (in some cases a vaccine dose is required on top). Considering people have had Covid multiple times, a generic exemption for them might be too broad.

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