Cannabis first domesticated 12,000 years ago

>I like weed as a productive drug, it's stronger than caffeine for me, but I develop tolerance and addiction quickly. Any solution to the tolerance problem? Quitting/breaks is obvious.

This is not something I've solved but are you consuming large amounts? I can stay high for months on end, using every hour and while it's not going to hit me like the first hit, I say up. I'd like to be more regular in consumption (every 4 hours), but your guess is as good as mine

>Is investing in weed stocks encouraging drug addiction/use? Is it ethical to promote drug use?

Is investing in any US-based company encouraging war? Is investing in any company that uses Chinese production promoting slavery? Caffeine is a drug. We take lots of drugs. We are in the infancy of understanding many of them because we're young and because we've been prudes.

I'd rather see companies and people I'd trust pushing and producing drug products of any kind rather than abusers. You can see this happening in the hemp adjacent markets - lots and lots of shady fly by night companies have popped up but slowly the good ones are rising to the top. 3chi, for example is a popular and I think solid d8 company.

But as I told my dad, every single person that was selling pot on the street is trying to get into the drug business and has been for more than a decade...good luck picking winners.

>Has anyone been able to convince a fortune 500 company that they need(medical) marijuana for work? As mentioned I'm significantly more focused, but I don't like the social stigma. I already have the job, it's purely a cultural/social problem.

> Are my memory problems due to weed or is this just age? (When not using) I feel like I've lost lots of childhood memories and I have more difficulty than ever with names.

This is my main concern (and lung damange). I do notice lapses in short-term memory (though I am high when this happens, I haven't noticed a huge drop). The literature sugests it's relatively small over decades IIRC. Willie Nelson and Snoop (sample of 2) are doing ok.

>If my focus is better on weed, is there something else I can do for focus that isn't drug related?

Get off HN. ;)

Medicinal Chemist (and former cannabis consumer) here.

>I like weed as a productive drug, it's stronger than caffeine for me, but I develop tolerance...

Interestingly, I used to notice that once I became tolerant to one strain, over a couple weeks, switching to another strain could at least partially alleviate it.

This to me is fascinating. Psychoactive effects of cannabinoids are thought to be mediated by the CB1 receptor. Cannabis strains can vary strongly in their perceived effects. Are there subtypes of the CB1 receptor differentially activated by the various cannabinoids present at different levels in the strains? For instance CB1a and CB1b? I do not think this is known.

>If my focus is better on weed, is there something else I can do for focus that isn't drug related?

This sounds like a line from John Stewart in some stoner movie

Smoked weed every day for 10 years.

>I like weed as a productive drug, it's stronger than caffeine for me, but I develop tolerance and addiction quickly. Any solution to the tolerance problem? Quitting/breaks is obvious.

Switch strains frequently, try to find stuff far from the other.

>Is investing in weed stocks encouraging drug addiction/use? Is it ethical to promote drug use?

No, but also investing in weed stocks are probably not the best stocks you could invest in - that said: Invest in what you know!

>Is there a way to microdose? I'd like to be able to have tiny, controlled amounts every time.

Yes, but you'll have to take a huge long break to get your tolerance back down. Then make tea: https://www.thrillist.com/eat/nation/how-to-make-cannabis-te...

>Is there a solution to munchies?

Switch strains - tends to be more common in Indicas with a higher than normal CBD (or if you're into more "creative" solutions, low dose adderall with it, seems to balance out well in strains that cause munchies.)

>Has anyone been able to convince a fortune 500 company that they need(medical) marijuana for work? As mentioned I'm significantly more focused, but I don't like the social stigma. I already have the job, it's purely a cultural/social problem.

If you have a Drs note, there isn't much they can do.

> Are my memory problems due to weed or is this just age? (When not using) I feel like I've lost lots of childhood memories and I have more difficulty than ever with names.

I've read reports of this, I've anecdotally heard people say that - It's never been a problem for me (but aging certainly has)

>If my focus is better on weed, is there something else I can do for focus that isn't drug related?

Diaphragmatic breathing for 5 minutes when you find your mind wandering.

I’ve also found edibles to be the best way to control dosing. Though in my case I’ve never found cannabis to be a productive drug - I mini-dosed for leisure only and to great effect.