Disclaimer: I studied media theory and publishing, but well before the Web became the all-decisive factor. Meaning, I have some idea about those things and have still an interest in them. (Also, I actually programmed ad embedding mechanisms for ad networks, but quit this field, when things became too invasive and ads too aggressive and I couldn't justify this any longer. – At this time, tracking was commonly done for multistage campaigns only.)
That said, I've never come upon a study that showed significant gains due to targeting, rather to the contrary. – So, after a decade, I'm still waiting for any proof in favor of targeting. (The suspicion must be still that targeting is rather a lazy alternative to media analysis and its perceived advantage is rather rooted in minimising efforts than in effectiveness.)
Regarding "Facebook has created the most sophisticated ad targeting engine", this is a rather biased proposition. It has enforced Facebook as a broker, made advertising cheap, while less effective, and has driven ad revenues for content providers downhill. (Google is to blame, as well.)