> tetratogenic
That’s like a teratogen, but four times as bad!
Temozolomide Is Explosive
41–50 of 128 posts
Re: Temozolomide Is Explosive
#42Found the safety sheet for TMZ:
https://www.merck.com/docs/product/safety-data-sheets/hh-sds...
Nothing about explosions other than dust explosion warnings, but this one is kind of amusing:
"H351 Suspected of causing cancer"
Re: Temozolomide Is Explosive
#43Earlier quoted context omitted.
And just handling/storage. Things that are flammable or explosive have more-stringent requirements. A familiar example: one should take much greater care when storing rubbing alcohol (or Bacardi 151 or vodka) than wine. One will magnify a house-fire. The other will help to douse a flame.
At every people’s house, I see a cupboard with the chemicals. WD-40, 90° alcohol, acetone, white spirit, all in the same IKEA (=plywood) cupboard (although it would be hard to protect children if they were each in a different cupboard too). I wonder how many fires start from the chemicals cupboard. We know that a lot of artists had their rag pile spontaneously heating up then catching fire…
Those things are fine in their separate containers. They will not spontaneously combust. If the containers are leaking, or fire starts elsewhere, yeah they could become fuel. But really no more than any other hydrocarbons in your house (e.g. wood, plastic, cloth, upholstrey and foam cushions, etc.)
Re: Temozolomide Is Explosive
#44Earlier quoted context omitted.
Nitrogen-Nitrogen bonds inside larger molecules are never quite stable because 1) nitrogen “wants” to form stable di-nitrogen (N2) molecules containing a very stable triple bond (an exothermic reaction) and 2) the result of such decompositions is nitrogen gas increasing the amount of entropy released (due to more molecules being created). Reactions are driven both by the amount of heat released (enthalpy) and the amo…
Does the same apply to oxygen? Since it also likes to be in a diatomic form.
Oh, yes. Every substance carrying a „peroxo“ in its name is usually nasty stuff. Concentrated hydrogenperoxide for example can explode creating gaseous water (aka steam) and dioxygen (aka oxygen) in the process. While O2 is a corrosive, it is quite inert under normal conditions (which is why our clothes don’t burst into flames spontaneously).
Re: Temozolomide Is Explosive
#45Chemotherapy is basically cave man medicine. That a therapeutic drug is explosive only adds to that sentiment. The idea that we'll basically poison you just up to a point that's nearly fatal in order to kill the cancer is such a terrible way to treat someone. Now I'm not saying don't ever do it -- unfortunately that's where we're at in 2021. It's just kind of unbelievable that cancer remains so elusive that we're sti…
>Perhaps one day we'll be able to simulate the body well enough to the point where we can brute force treatments computationally to fix this gap.
This is why as a total outsider/non-expert I believe we will cure everything in the next 50 years if we do not regress or destroy ourselves.
Re: Temozolomide Is Explosive
#46Maybe helpful to note that the phrase "Class 1 Explosive" isn't denoting a certain type, or power of "Explosive". "Class 1" in Hazmat is all explosives. Class 2 is Gases. Class 3 is Flammable or Combustible liquid, and so on.
So a liquor cabinet is full of Class 3 explosives.
Re: Temozolomide Is Explosive
#47"What they found was rapid onset of decomposition at 170 degrees" So this seems to be more about people in a lab situation rather than it being so unstable it reacting sitting in someone's hot car. Suspecting it to react at 212 and finding it reacting at 170 could ruin a lab tech's day to be sure. Those are the jobs that sound fun "for the science" lets see what happens when...
"Decomposition" doesn't usually mean 'explodes', either.
Curiously, Wikipedia still shows the old definition [1]:
> Temozolomide is an imidazotetrazine derivative. It is slightly soluble in water and aqueous acids, and decomposes at 212 °C (414 °F).[15]
The [15] citation from Wikipedia is to a 1982 book, untranslated from German. That may be one example of "the literature" that Derek cites. The factoid was added in this edit [2] by an Austrian Wikipedia editor who works on a lot of chemistry articles. I'd wager that the number of people who are English-German bilingual chemists with this book from 1982 on their shelf who edit Wikipedia is exactly one, and further, that he did not experimentally test or have other familiarity with the compound to sanity check the fact. This puts "the literature" in a very different context than the broad consensus of well-known, agreed-upon facts that I'd usually assume a constant value to have.
[1]: https://en.wikipedia.org/wiki/Temozolomide#Chemical_properti...
[15]: Dinnendahl, V; Fricke, U, eds. (2016). Arzneistoff-Profile (in German). 9 (29 ed.). Eschborn, Germany: Govi Pharmazeutischer Verlag. ISBN 978-3-7741-9846-3.
[2]: https://en.wikipedia.org/w/index.php?title=Temozolomide&diff...
Re: Temozolomide Is Explosive
#48Somewhat surprisingly, this was NOT filed under "Stuff I Won't Work With"
It sounds like this stuff is only mildly dangerous and easy to keep safe with if you know what you're doing. Considering that it's been used as a chemotherapy drug for years, it'd be surprising if it wasn't.
Most of the "Stuff I Won't Work With" is fantastically dangerous even when you know exactly what you're dealing with and take all of the right precautions.
Re: Temozolomide Is Explosive
#49Chemotherapy is basically cave man medicine. That a therapeutic drug is explosive only adds to that sentiment. The idea that we'll basically poison you just up to a point that's nearly fatal in order to kill the cancer is such a terrible way to treat someone. Now I'm not saying don't ever do it -- unfortunately that's where we're at in 2021. It's just kind of unbelievable that cancer remains so elusive that we're sti…
My understanding is that chemotherapy is indiscrimate when it attacks cells - it affects cancerous and healthy cells alike. However, doctors assume the healthy cells will recover from the weakening effects of chemotherapy. Meanwhile the cancer cells are stressed to a greater degree by the chemotherapy and thus suspectible to death. All this is presented as the "best outcome" scenario for chemotherapy treament.
However, for some patients (and depending on their type of cancer) chemotheraphy can leave lingering side-effects and can even cause cancerous cells to recur or turn even more aggressive. For some cancer patients, chemotherapy is not about curing the cancer but slowing the cancer spread ("treatable but not curable" is the phrase used by doctors for some cancer conditions).
Although chemotheraphy can be succesful for some (many?) patients, as you say it still feels like a crude, blunt approach to treating cancer. Doctors might baulk at that description. But consider: if someone has a non-metasized cancer (i.e. cancer in one part of the body that has not spread to other parts of the body), chemotherapy is applied with blunt force to the entire body including to the majority of healthy cells in the body. I can't see how anyone can say this isn't a coarse and crude treatment method even when the outcome is deemed successful.
Re: Temozolomide Is Explosive
#50Chemotherapy is basically cave man medicine. That a therapeutic drug is explosive only adds to that sentiment. The idea that we'll basically poison you just up to a point that's nearly fatal in order to kill the cancer is such a terrible way to treat someone. Now I'm not saying don't ever do it -- unfortunately that's where we're at in 2021. It's just kind of unbelievable that cancer remains so elusive that we're sti…
Chemotherapy combined with surgery and radiation is still a standard and still does cure a significant portion of people - my father's cancer was cured by this "ordinary method".
The problem is that more selective methods of killing cancers run up against the tendency of cancer cells to mutate and find a defense against them.
And this is definitely stuff that's killing you and the cancer and hoping the cancer dies first. To keep going, you need a strong reason to live.