Live data from Hacker News

Death rates are declining for many common cancers in the U.S., report finds

statnews.com

61–70 of 99 posts

Re: Death rates are declining for many common cancers in the U.S., report finds

#61
post #30

Earlier quoted context omitted.

What does clean living mean? Living in small towns away from pollution? Washing produce more thoroughly?

They mean thinking about your diet, exercise, mental welling and other health issues. It doesn't literally mean 'clean' as in 'not dirty'.

That's so vague as to be meaningless.

Re: Death rates are declining for many common cancers in the U.S., report finds

#62

I created this account on July 28, 2014 [1] - I had(have?) stage IV Colon Cancer with liver metastases. I did a FOLFIRI regime with cetaximab, then a colon resection with a general surgeon. My oncologist was great (ucsf medical center) - but the surgeon refused to address my liver mets - they were too large and distributed. My wife found out about a specialist at Sloan-Kettering in Manhattan that uses something calle…

Is it in remission yet?

Re: Death rates are declining for many common cancers in the U.S., report finds

#63

I created this account on July 28, 2014 [1] - I had(have?) stage IV Colon Cancer with liver metastases. I did a FOLFIRI regime with cetaximab, then a colon resection with a general surgeon. My oncologist was great (ucsf medical center) - but the surgeon refused to address my liver mets - they were too large and distributed. My wife found out about a specialist at Sloan-Kettering in Manhattan that uses something calle…

Thanks for sharing your story. It's a good reminder about how oncology is still as much as art as a science, and outcomes vary widely depending on whether you have access to the right providers.

Re: Death rates are declining for many common cancers in the U.S., report finds

#64

Earlier quoted context omitted.

Are you kidding me????? My dad was diagnosed with a very rare type of stomach cancer called GIST at 42. The average survivability at that stage for GIST at that time was 6-12 months. Zero patients lived more than 5 years. He was given experimental(at the time) drug called Glivec as it was being tested specifically against GIST and it was literally one of these "there's nothing else, so might as well". He lived anothe…

Consider that a 40 year old today can live 40+ more years. so even 4 extra years with experimental treatments is small relative to potential life expectancy without cancer. 4 years is still optimistic given that stage 4 survival for major cancers instill in the 3-20% range depending on the cancer. Speaking of the number 4, awesome my comment already at -4, which is the cap.

I doubt Sesame Street is going to hire you with that attitude.

Re: Death rates are declining for many common cancers in the U.S., report finds

#65
post #4
post #3

Earlier quoted context omitted.

CAR-T therapy is absolutely how we imagined the “genetic age” would be. However, its applications to liver cancer (as well as other solid tumors) are far away from clinics. Some cancers haven’t seen much progress in the last 30 years. For example, uveal melanoma is a death sentence, same as 30 years ago. Liver metastases don’t give you any chance.

Similarly, glioblastoma (a brain cancer) is still a death sentence. My dad died of it a little over 5 years ago, lasting about a year and a half from initial diagnosis. Maybe a year later, John McCain came down with the same thing. In a weird way it was comforting to know that all the money and power in the world didn't make any difference in the outcome.

It's strangely satisfying to see a billionaire or a powerful politician die. Reminds you of how human we all are.

Re: Death rates are declining for many common cancers in the U.S., report finds

#66
post #58

I wonder if someone could give me feedback on this. I heard that basically all cancer cells switch over to aerobic respiration, ie fermentation, and that in this metabolic mode they can use glucose and the amino acid glutamine as fuel but not ketones. So some people have treated their cancer by eating zero carbohydrates and taking a special drug that disables glutamine, doing so intermittently, and they have seen inc…

A ketogenic diet or even a less restrictive lower carbohydrate diet can contribute to a slowing of the cancer growth for some cancers because cancer metabolizes large amounts of glucose. But keep in mind that many cancer patients cannot afford to lose weight, which makes such dietary changes very difficult.

The incredible stories that you hear are often true (stage 4 cancer remissions do occur) but usually involve selection bias. Usually it is hard to know what exactly worked, and it isn't going to work for everyone else.

If you are interested in looking more deeply into complementary cancer treatments I would recommend looking into the work of Ralph Moss.

Re: Death rates are declining for many common cancers in the U.S., report finds

#67

If you are interested in more of the history behind the different cancer treatments that we have today, "The Emperor of All Maladies: A Biography of Cancer" is a fantastic book about it. Probably my favourite book of all time, a lot of parallels with the themes in this article about prevention being a huge contributor, and how recently we've had some success in very targeted cancer drugs.

If someone wants a different take on why cancer treatment has progressed very slowly, there is "Cancer, Incorporated" by Ralph Moss.

Re: Death rates are declining for many common cancers in the U.S., report finds

#68

I created this account on July 28, 2014 [1] - I had(have?) stage IV Colon Cancer with liver metastases. I did a FOLFIRI regime with cetaximab, then a colon resection with a general surgeon. My oncologist was great (ucsf medical center) - but the surgeon refused to address my liver mets - they were too large and distributed. My wife found out about a specialist at Sloan-Kettering in Manhattan that uses something calle…

[deleted]

Re: Death rates are declining for many common cancers in the U.S., report finds

#69
post #37

Earlier quoted context omitted.

This sounds like something insurance will either refuse to cover for being expensive or make you try 5 other approaches first before agreeing to cover it, at which point it'll probably be too late.

Unlikely. It will rule out treatments that are unlikely to work, saving money. What we are seeing is Simpson’s paradox. Genomics and precision medicine allow you to segment populations at a higher resolution then before.

Exactly. Insurance companies are very interested in Real World Data (RWD) around genomic based treatments. By using those data they can have a better sense of which patients would be likely to respond to which drugs, and steer treatment that way.

Re: Death rates are declining for many common cancers in the U.S., report finds

#70

I created this account on July 28, 2014 [1] - I had(have?) stage IV Colon Cancer with liver metastases. I did a FOLFIRI regime with cetaximab, then a colon resection with a general surgeon. My oncologist was great (ucsf medical center) - but the surgeon refused to address my liver mets - they were too large and distributed. My wife found out about a specialist at Sloan-Kettering in Manhattan that uses something calle…

> and writing the damn software you're using right now

Which software? :o Curious!

Thank you for sharing, by the way.

Post reply on HN