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Death rates are declining for many common cancers in the U.S., report finds

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Re: Death rates are declining for many common cancers in the U.S., report finds

#21

I agree, my dad was diagnosed with stage 3 colon cancer in 2020. One of the drugs that he was given as part of the anti-cancer regimen "Avastin" - starves the tumor of blood supply, effectively limiting growth, this differs from conventional chemo which attacks both healthy and cancer cells. After 22 cycles, he went into remission earlier this year.

Are there no downsides to Avastin? How long is a cycle?

Re: Death rates are declining for many common cancers in the U.S., report finds

#22

A close family member has stage 4 cancer. Even if the absolute death rates for some cancers are relatively unchanged, one of the amazing things I’ve observed is that medical advances have increased the long term survival rates of terminal/metastaticized cancers. It’s partially due to the development of various drugs that have been identified as effective against various specific mutations. Even if the cancer is incur…

One of the interesting developments is precision medicine: we can now use genomic sequencing and AI to "search" for the treatment that is most likely to be effective against a particular individual's cancer rather than following the rough "standard of care" playbook (for example, depending on the type of cancer, the standard of care might be 6 months of chemo, and if that doesn't work try something else, repeat until…

This sounds like something insurance will either refuse to cover for being expensive or make you try 5 other approaches first before agreeing to cover it, at which point it'll probably be too late.

Re: Death rates are declining for many common cancers in the U.S., report finds

#23

A close family member has stage 4 cancer. Even if the absolute death rates for some cancers are relatively unchanged, one of the amazing things I’ve observed is that medical advances have increased the long term survival rates of terminal/metastaticized cancers. It’s partially due to the development of various drugs that have been identified as effective against various specific mutations. Even if the cancer is incur…

for a 40 year old diagnosed with stage 4 cancer ,a few extra years ain't much

Are you kidding me?????

My dad was diagnosed with a very rare type of stomach cancer called GIST at 42. The average survivability at that stage for GIST at that time was 6-12 months. Zero patients lived more than 5 years.

He was given experimental(at the time) drug called Glivec as it was being tested specifically against GIST and it was literally one of these "there's nothing else, so might as well".

He lived another 8 years after that, until cancer came back and the drugs stopped working.

When he was first diagnosed I was a teenager, my sister was a child - thanks to this drug he was able to see his kids go into adulthood, and obviously spend 8 more years with his wife.

How is that "ain't much"??????

Re: Death rates are declining for many common cancers in the U.S., report finds

#24

Earlier quoted context omitted.

One of the interesting developments is precision medicine: we can now use genomic sequencing and AI to "search" for the treatment that is most likely to be effective against a particular individual's cancer rather than following the rough "standard of care" playbook (for example, depending on the type of cancer, the standard of care might be 6 months of chemo, and if that doesn't work try something else, repeat until…

This sounds like something insurance will either refuse to cover for being expensive or make you try 5 other approaches first before agreeing to cover it, at which point it'll probably be too late.

To the extent this is true today, I suspect it's precisely because the precision medicine approach is not yet the standard. I.e., insurance companies want you to do the standard of care, but if/when precision medicine _becomes_ the standard then insurance companies will embrace it (or that's my hypothesis, anyway).

Re: Death rates are declining for many common cancers in the U.S., report finds

#26

Earlier quoted context omitted.

for a 40 year old diagnosed with stage 4 cancer ,a few extra years ain't much

Are you kidding me????? My dad was diagnosed with a very rare type of stomach cancer called GIST at 42. The average survivability at that stage for GIST at that time was 6-12 months. Zero patients lived more than 5 years. He was given experimental(at the time) drug called Glivec as it was being tested specifically against GIST and it was literally one of these "there's nothing else, so might as well". He lived anothe…

I appreciate you taking the time to tell your story. It’s easy to view expensive treatments that only extend someone’s life by a year or two as too costly but those remaining years can be the most important for that person and their friends/family.

Re: Death rates are declining for many common cancers in the U.S., report finds

#27

In addition to medical developments, I think that clean living has become more popular than ever. In 2021, you see people who would never have been interested in a healthy diet eating properly. And obesity is an significant risk factor for cancer.

The obesity rate has continued to increase.

Re: Death rates are declining for many common cancers in the U.S., report finds

#28

Earlier quoted context omitted.

One of the interesting developments is precision medicine: we can now use genomic sequencing and AI to "search" for the treatment that is most likely to be effective against a particular individual's cancer rather than following the rough "standard of care" playbook (for example, depending on the type of cancer, the standard of care might be 6 months of chemo, and if that doesn't work try something else, repeat until…

This sounds like something insurance will either refuse to cover for being expensive or make you try 5 other approaches first before agreeing to cover it, at which point it'll probably be too late.

This is partly why it’s important to save for retirement so you can be well capitalized to fund such treatments on your own if they should become necessary.

Re: Death rates are declining for many common cancers in the U.S., report finds

#29

Earlier quoted context omitted.

for a 40 year old diagnosed with stage 4 cancer ,a few extra years ain't much

Are you kidding me????? My dad was diagnosed with a very rare type of stomach cancer called GIST at 42. The average survivability at that stage for GIST at that time was 6-12 months. Zero patients lived more than 5 years. He was given experimental(at the time) drug called Glivec as it was being tested specifically against GIST and it was literally one of these "there's nothing else, so might as well". He lived anothe…

Consider that a 40 year old today can live 40+ more years. so even 4 extra years with experimental treatments is small relative to potential life expectancy without cancer. 4 years is still optimistic given that stage 4 survival for major cancers instill in the 3-20% range depending on the cancer.

Speaking of the number 4, awesome my comment already at -4, which is the cap.

Re: Death rates are declining for many common cancers in the U.S., report finds

#30

In addition to medical developments, I think that clean living has become more popular than ever. In 2021, you see people who would never have been interested in a healthy diet eating properly. And obesity is an significant risk factor for cancer.

What does clean living mean? Living in small towns away from pollution? Washing produce more thoroughly?
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