> Any philosophy that just asserted that the Universe has meaning was a non-starter, for me.
> Humans create meaning in the face of an uncaring, indifferent Void.
I hope you realize that your assertion, which asserts a complete lack of meaning, is just as strong as the philosophies that assert meaning. To me, both are non-starters.
To make progress one has to question the framing of the problem, which is actually what most of the continental philosophy enlightenment onwards was about.
Maybe meaning already requires consciousness that looks out at the world, so it would be a contradiction to claim the things in themselves has meaning. (subjective)
Or maybe there is meaning in things themselves, but there is an intelligibility problem and we can't have a sufficiently comprehensive representation of it internally. (objective). Think it as the model file not fitting a single machine.
Or maybe meaning is a process that requires both the conscious looker and a meaning in things themselves, and is dynamically loaded. (neither subjective nor objective). It can still be constrained by cognitive capacity or intelligibility, but maybe we're doing a pretty good job at it nonetheless because we are able to conform to reality in an adaptive manner, and survive better than any other species with our modeling. Also we have been coming up with technologies to beef us up on the intelligibility and capacity fronts; like invention of literacy!
So maybe existential depression is a mere stuckness in a local minima of this meaning making process between the conscious looker and objective reality, in no small part thanks to our current philosophical and other institutions really sucking at training us on the dynamic loading process. Nor we have the supporting education to leverage the collective intelligence of the best of the humanity (remember, we've invented literacy, but what is the use if we don't read the most important stuff on this matter?). Without these constraints addressed, "there is definitely no meaning" sounds to me like giving up on looking for one's keys because they are tired and don't feel like they have made any progress. I am not saying there are definitely keys either, but it is a worthy endeavor to try getting better at looking for it at least.