mRNA is the ultimate biohacking tool. You can potentially use it for weight loss by improving metabolism without exercising and a few other things.
What mRNA is good for, and what it maybe isn’t
91–100 of 152 posts
Re: What mRNA is good for, and what it maybe isn’t
#92“The huge success of the mRNA vaccination platform” Does anyone know what the agreed upon criteria for asserting the success of mRNA vaccinations is? Aren’t we anticipating an uptick in cases in the US as we approach winter? Why are we assuming success already?
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> We haven’t even had a legitimate debate about whether the vaccinations created the DELTA STRAIN
Please explain the exact mechanism through which this would happen
Re: What mRNA is good for, and what it maybe isn’t
#93> mRNA can only be used to make the body make proteins that, well, the body can make. This might seem obvious, but it’s a pretty key part of where Moderna’s “software of life” analogy falls flat. It’s a limited software with limited toolkits. You’re not going to use mRNA in humans to make, say, an antibiotic that’s naturally produced in fungi. Hmm? I keep hearing about plants and bacteria that have been genetically m…
I believe this a reply to klevertree's comment, rather than the article: https://news.ycombinator.com/item?id=27682445
Re: What mRNA is good for, and what it maybe isn’t
#94Earlier quoted context omitted.
> LSD "the only drug measured in micrograms" Carfentanil is probably more potent then LSD, here is a lethal dose: https://mediad.publicbroadcasting.net/p/wosu2/files/styles/x... "For pain relief, a unit of carfentanil is one hundred times as potent as the fentanyl, five thousand times as potent as heroin, and ten thousand times as potent as morphine, despite having only 14 to 135 times the affinity for the mu recepto…
That carfentanil looks like about a milligram, but impossible to say without knowing its density.
1.0 µg of carfentanil is equivalent to 10 mg of morphine
Re: What mRNA is good for, and what it maybe isn’t
#95Earlier quoted context omitted.
I don't think it is correct to say only one drug is measured in µg. Levothyroxine (for underactive thyroid) is typically administered in µg doses - but patient confusion with the more common mg means most medical staff will translate any mg dose a patient claims to be taking to µg automatically. It may be atypical, but it's certainly not rare for drugs to be µg doses.
I think the earlier commenter meant ‘drug’ as in street drug. But though that may have once been true, these days there are plenty of other designer drugs that come in tiny doses, many of them not as friendly as LSD.
I don't understand why both are called drugs in English. My language also has the word "drugs" but it's used exclusively for street drugs.
Re: What mRNA is good for, and what it maybe isn’t
#96Of course now after the fact that mRNA vaccines are hugely outperforming other technologies in COVID, we know that they are our best bet for other infectious diseases as well (including having a much better flu vaccine), but Moderna+BioNTech got a lot of money last year to find it out, and this was not that clear 1 year ago.
What the article doesn't answer to me, is how to cure my 40 year old ex girlfriend with metabolic breast cancer. Sorry, but giving up on people just because it's technically challenging is not an answer to me. If the CAR-T or TIL therapies can cure her, I agree that the mRNA therapy route should be stopped, but right now trying all possible routes is my best bet to not be at her funeral.
Re: What mRNA is good for, and what it maybe isn’t
#97> mRNA can only be used to make the body make proteins that, well, the body can make. This might seem obvious, but it’s a pretty key part of where Moderna’s “software of life” analogy falls flat. It’s a limited software with limited toolkits. You’re not going to use mRNA in humans to make, say, an antibiotic that’s naturally produced in fungi. Hmm? I keep hearing about plants and bacteria that have been genetically m…
A protein is often not just amino acids, but also a bunch of so-called post-translational modifications(PTM). These could be carbohydrates that have distinct functional roles, e.g. targeting. Members of different kingdoms have distinct PTMs which makes it difficult to just make a bacteria produce human protein. But bacteria you can modify genetically, human - not so much.
Re: What mRNA is good for, and what it maybe isn’t
#98Earlier quoted context omitted.
I think the earlier commenter meant ‘drug’ as in street drug. But though that may have once been true, these days there are plenty of other designer drugs that come in tiny doses, many of them not as friendly as LSD.
I don't understand why both are called drugs in English. My language also has the word "drugs" but it's used exclusively for street drugs.
Drugs having to be government approved is a relatively recent development.
Perhaps about a hundred years, give or take. See https://en.wikipedia.org/wiki/International_Opium_Convention
The English language just hasn't caught on, yet. At least not completely.
In eg German, people generally differentiate between Medikamente and Drogen, but they still have a Drogerie which is essentially the same as a drug store.
Re: What mRNA is good for, and what it maybe isn’t
#99Earlier quoted context omitted.
Correct me if i am wrong but those highly effective mRNA vaccines were created in a few weeks and relatively inexpensively... and can other protein targets can be repackaged easily by coding the mRNA unit into the already encapsulated delivery mechanism. is that not better than the other alternatives?
No, the same advantages apply to the other alternatives I mentioned. If you have a target protein design ready, it can be readily plugged into mRNA, DNA, or protein subunit technology.
alright... thanks for that explanation. I thought it was more unique to the mRNA version that those but I was wrong.
Re: What mRNA is good for, and what it maybe isn’t
#100Earlier quoted context omitted.
the theraputics part is different than the immune system response part. they said in the theraputics part you don't get to use the immune system memory because the immune system memory is there to make a foreign enough protein that looks like the virus receptors so the body learns how to kill those proteins. a therapeutic doesn't want you to kill the proteins it creates because the proteins created need to be able to…
Thanks. If I'm correct then the mRNA vaccine introduces proteins that reflect the virus and trigger the immune response? I think I was reading the article as mostly focused on vaccines, but it was focused on cancer treatment, hence my confusion...
Kinda... the mRNA is the code for the cells to make the protein that resembles the virus. traditionally it was a virus or a part of a virus that was made that gets directly killed by the immune system for being different.