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Is one vaccine dose enough if you’ve had Covid? What the science says

nature.com

31–40 of 44 posts

Re: Is one vaccine dose enough if you’ve had Covid? What the science says

#31

Why doesn't getting Covid and then allowing your body to produce your own immunity not protect you from getting it again? As I understand the variants are not like the flu or the cold (yet!)

It probably does.

We just haven't had enough time to prove it yet, or to investigate the differences between variants.

Re: Is one vaccine dose enough if you’ve had Covid? What the science says

#32
post #25

Earlier quoted context omitted.

iirc for some reason the amount of antibodies you have falls sharply after 1-3 months and you're vulnerable again. anecdotally, a friend of a friend (EMT) had covid like 4 times before vaccines were available.

Bullshit. SARS 1 produces immunity against COVID and every other coronavirus has natural immunity. Your friend had some colds, the flu, maybe COVID once, and potentially false positive tests. Antibodies do drop but they're not the only part of the immune system. T cells have memory and will remember the antigen

this video is good simple(ish) explaination - note it says bacteria, but the vid is for most things that are invasive

https://www.youtube.com/watch?v=zQGOcOUBi6s&list=PLsboZGJ1JM...

It's from the Kurzgesagt – In a Nutshell channel

Re: Is one vaccine dose enough if you’ve had Covid? What the science says

#33

Earlier quoted context omitted.

Did you not get an antibody test at some point prior to the vaccine? That would have given you an answer with 99% certainty if you used a good one.

I think they are relatively expensive, ~$200. Probably worth it though. We would need some form of official recognition of antibody tests though. Pretty sure most places that require vaccination don't accept antibody test results.

Antibody tests have been widely made available for free across the developed world.

In NYC, for example, they've been available for free at a ton of different sites. It may always be as convenient or quick, but it's free.

Re: Is one vaccine dose enough if you’ve had Covid? What the science says

#34
post #29

> Research shows that a previous coronavirus infection plus one dose of vaccine provides powerful protection — but concerns linger This is one thing that’s been incredibly frustrating throughout this whole pandemic. Studies and research will show B, with no sign of A, however inertia/politics/fear/ignorance will continue to push A to the point of harm. An example - a local store was insisting on wiping down the entir…

> a local store was insisting on wiping down the entire checkout conveyor with alcohol between every single customer until very recently, when we’ve know for a long time that you won’t get COVID from that. As someone from a country where running orders are still to disinfect often-touched surfaces (switches, door handles, office desks, etc.) I was surprised by this. I went to check what CDC from US recommends. It tur…

https://www.nature.com/articles/d41586-021-00251-4

Cleaning for an airborne illness is just theater. Upgrading air handlers, increasing airflow, and spacing people further apart matter. Cleaning stuff randomly just makes people feel better (but can make good business sense because of this!)

Re: Is one vaccine dose enough if you’ve had Covid? What the science says

#35

seems like there's some consensus on two "exposures" worth of immunity being valuable. any data on second shots for folks who took the J&J?

The cynical part of me thinks that J&J is only 1 shot because your body develops strong immunity to it adenovirus-26 vector, so a 2nd shot would get immediately killed off before its spike protein payload could take any action. Until your immunity to it wanes anyway.

This is suspected to be a problem with the Oxford vaccine which also uses one virus vector for both doses.

Like Sputnik V, J&J's Janssen unit's Ebola vaccine uses two different virus vectors. And Janssen is doing an ENSEMBLE 2 Phase III clinical trial with two doses eight weeks apart that lol768 mentions. But their primary objective stated from the very beginning was to create the most effective single dose vaccine possible, and vaccinated a billion people in 2021.

They appear to have achieved the former, although Sputnik Lite with the same Ad26 based vector could be a competitor, the latter goal is failing due to inherent issues with using cell culturing to make something, a strained supply chain for that which is also required to make Oxford's Sputnik V, and Novavax's vaccine (bug cell grown protein plus adjuvant), and being forced to use the dangerously incompetent Emergent BioSolutions as a subcontractor.

Re: Is one vaccine dose enough if you’ve had Covid? What the science says

#37

Why doesn't getting Covid and then allowing your body to produce your own immunity not protect you from getting it again? As I understand the variants are not like the flu or the cold (yet!)

It probably does. We just haven't had enough time to prove it yet, or to investigate the differences between variants.

According to this (preprint) paper(n=52000), recovering from covid-19 protects just as well (or even slightly better) than getting vaccinated.

Also note that vaccines focus on the Spike protein only, and you're immunesystem takes the entire virus into account, which might offer better protection against variants.

https://www.medrxiv.org/content/10.1101/2021.06.01.21258176v...

Re: Is one vaccine dose enough if you’ve had Covid? What the science says

#38

Earlier quoted context omitted.

The cynical part of me thinks that J&J is only 1 shot because your body develops strong immunity to it adenovirus-26 vector, so a 2nd shot would get immediately killed off before its spike protein payload could take any action. Until your immunity to it wanes anyway.

This is suspected to be a problem with the Oxford vaccine which also uses one virus vector for both doses. Like Sputnik V, J&J's Janssen unit's Ebola vaccine uses two different virus vectors. And Janssen is doing an ENSEMBLE 2 Phase III clinical trial with two doses eight weeks apart that lol768 mentions. But their primary objective stated from the very beginning was to create the most effective single dose vaccine p…

Was J&J the most effective vaccine after 1 dose? Sure they don't have much competition if you only compare against 'approved' schedules, but mRNA vaccines seem better after 1 dose than J&J is. But yeah, there's just not a lot of trial data out there for 1dose mRNA or Oxford vaccine since they're (officially) pretty quick to get you to 2 doses.

Emergent BioSolutions was contamination between the J&J side of production with the Oxford/AstraZeneca vaccine side of production...

Re: Is one vaccine dose enough if you’ve had Covid? What the science says

#39
post #29

Earlier quoted context omitted.

> a local store was insisting on wiping down the entire checkout conveyor with alcohol between every single customer until very recently, when we’ve know for a long time that you won’t get COVID from that. As someone from a country where running orders are still to disinfect often-touched surfaces (switches, door handles, office desks, etc.) I was surprised by this. I went to check what CDC from US recommends. It tur…

https://www.nature.com/articles/d41586-021-00251-4 Cleaning for an airborne illness is just theater. Upgrading air handlers, increasing airflow, and spacing people further apart matter. Cleaning stuff randomly just makes people feel better (but can make good business sense because of this!)

yes, cleaning surfaces regularly (but not excessively) is good for a variety of reasons, but not for covid. the airflow concern is also overblown though. you really just need modest distancing indoors (or masks, absent modest distancing). no need for fancy airflow handling. covid isn't a robust virus that, as it's tiny water-bubble craft rapidly evaporates, quickly falls apart outside the body (similar to why surfaces aren't a concern).

Re: Is one vaccine dose enough if you’ve had Covid? What the science says

#40
post #37

Earlier quoted context omitted.

It probably does. We just haven't had enough time to prove it yet, or to investigate the differences between variants.

According to this (preprint) paper(n=52000), recovering from covid-19 protects just as well (or even slightly better) than getting vaccinated. Also note that vaccines focus on the Spike protein only, and you're immunesystem takes the entire virus into account, which might offer better protection against variants. https://www.medrxiv.org/content/10.1101/2021.06.01.21258176v...

PHE are doing one too:-

https://www.gov.uk/government/news/past-covid-19-infection-p...

>>PHE scientists working on the study have concluded naturally acquired immunity as a result of past infections provide 83% protection against reinfection, compared to people who have not had the disease before. This appears to last at least for 5 months from first becoming sick.

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