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CRISPR gene-editing breakthrough opens door to treating broad array of diseases

npr.org

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Re: CRISPR gene-editing breakthrough opens door to treating broad array of diseases

#211

Post by DrAwdeOccarim »

iandanforth wrote: post #210
DrAwdeOccarim wrote: post #195

Earlier quoted context omitted.

It's coming very, very soon. Verve just IPO'ed and you check out their S1 to see their data on using the exact same idea (N1mΨ mRNA + gRNA inside LNP) to treat hypercholesterolemia! The data look amazing in non-human primates, which based on the Intellia data, suggest 10-fold lower dose in humans should work just fine. https://www.biospace.com/article/releases/verve-therapeutics...

That's amazing! How does one register as a potential patient for the trials?

www.clinicaltrials.gov once their IND is open, you'll be able to find it there! My guess is it's a year or so away before they start recruiting.

Re: CRISPR gene-editing breakthrough opens door to treating broad array of diseases

#212

Post by _djo_ »

lagadu wrote: post #197
nitrogen wrote: post #86

Earlier quoted context omitted.

Stop with the doom trolling and get busy inventing solutions.

We have solutions, there's an entire field with solutions, it's called climate engineering[0]. The problem is that currently it's not politically supported because the thought of humans actively editing the climate to suit our needs makes the wildly vast majority of environmentalists start foaming at the mouth and, ironically, doom trolling any solutions because the current thought paradigm is "we have to interfere l…

That's a simplistic take and unfair to those who are cautious about it.

Most opposition to climate engineering is based on the risks of introducing more instability to a complex system we already don't completely understand. For instance experiments to fertilize oceans with iron to supposedly stimulate phytoplankton production had all kinds of unexpected side effects and failed to produce the hoped-for outcome.

We will certainly be forced into climate engineering solutions of some sort, as emission reductions alone are no longer sufficient to solve the problem even if we drop to net zero immediately, but they should be treated with caution and skepticism because of the inherent risk involved.

It also varies by the type of engineering. CO2 sequestration is widely accepted and desired because of its low risk, but it's difficult and expensive.

Re: CRISPR gene-editing breakthrough opens door to treating broad array of diseases

#213

Post by jtbayly »

pm90 wrote: post #176
WheelsAtLarge wrote: post #158

It's only a matter of time before we use this to cosmetically modify our bodies. I predict that at the very least we'll use this technic to change our hair color and eye color. I will even say skin color too, with-in the next 50 years. Most people won't use it but there will be an active market , legal or illegal, for the modifications. The Sci-Fi future is here.

On the contrary, I think most people will use it and those that don’t will likely do so out of religious reasons. This is really great. Being born into the wrong set of genes seems like an incredibly silly thing to restrict humans to. Allowing humans to choose their appearance seems like it could resolve a bunch of psycho social issues and hopefully people can live more happy lives (although I am aware that these thi…

You... might want to read the story of the Sneeches by Dr. Seuss.

Re: CRISPR gene-editing breakthrough opens door to treating broad array of diseases

#214

Post by AbrahamParangi »

MeinBlutIstBlau wrote: post #27
changoplatanero wrote: post #8

Reminds me of this guy that cured himself of lactose intolerance. https://www.popularmechanics.com/science/health/a17804128/sc...

I think it's annoying people get upset that people who do this potentially damage their bodies. First of all, it's that individuals body. They can take whatever risks they want. I don't see how trying to alter your own DNA is any worse for you than skydiving. Both have inherent risks, none of which affect others. Secondly, because there is no red tape or ethical scientific practices required, this gives us the opport…

I think it’s sometimes a gatekeeping behavior, instinctual and unconscious.

If writing software required being a licensed engineer then you would without a doubt see reactions to open source, calling it deeply irresponsible and dangerous.

Re: CRISPR gene-editing breakthrough opens door to treating broad array of diseases

#215

Post by jonplackett »

jz_ wrote: post #118
jonplackett wrote: post #80

Wonder how long it will be until this is used to enhance rather than just to cure. Eg selective fast twitch / slow twitch muscle fibres.

Something like this? https://www.studyfinds.org/superhero-vaccine-olympic-dna-eua...

Haha. What could possibly go wrong?

Re: CRISPR gene-editing breakthrough opens door to treating broad array of diseases

#216

Post by civilized »

DoctorNick wrote: post #152
civilized wrote: post #132

Earlier quoted context omitted.

There are populated areas whose livability is threatened by climate change. These are in very poor, low-latitude regions like Northern India. Sorry to burst your bubble, but PNWers will have the privilege of surviving and thriving with relatively minimal issue. As always, the consequences of the environmental sins of the global wealthy, like you and me and most HNers, will be borne by the global poor in other places.…

I don't know if you've noticed, but the political process is completely fucking broken. Good fucking luck getting any of that passed in any meaningful form.

Yes, life is hard.

Yes, we have to live through it anyway.

Just like everyone else who lived before us.

Re: CRISPR gene-editing breakthrough opens door to treating broad array of diseases

#217

Post by _0ffh »

null_object wrote: post #189
alex_sf wrote: post #170

Earlier quoted context omitted.

All crops are GMO. The only difference is how fast they were modified.

> All crops are GMO. The only difference is how fast they were modified. This is often said in defense of GMO, but surely cross-breeding and hybridization - a farmer or gardener attempting to combine the entire genetic entity of one plant with another one (which must therefore be naturally compatible), to increase the potential utility of the result - is totally different to inserting a single gene from a totally arb…

And then there's Atomic Gardening which has been done for ages and does not officially count as producing GMOs, IIRC.

Re: CRISPR gene-editing breakthrough opens door to treating broad array of diseases

#219

Post by [deleted] »

ausbah wrote: post #43

>Doctors infused billions of microscopic structures known as nanoparticles carrying genetic instructions for the CRISPR gene-editor into four patients in London and two in New Zealand. The nanoparticles were absorbed by their livers, where they unleashed armies of CRISPR gene-editors. The CRISPR editor honed in on the target gene in the liver and sliced it, disabling production of the destructive protein. this is one…

[deleted]

Re: CRISPR gene-editing breakthrough opens door to treating broad array of diseases

#220

Post by oehtXRwMkIs »

esperent wrote: post #174
puchatek wrote: post #169

Earlier quoted context omitted.

If eating GMOs has you scared, this should be absolutely terrifying

So if I'm fine with GMO food (and medicine), by extension I'll fine with this. ... Or is that a logical fallacy?

The inverse of a conditional is not logically equivalent.
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