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CRISPR gene-editing breakthrough opens door to treating broad array of diseases

npr.org

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Re: CRISPR gene-editing breakthrough opens door to treating broad array of diseases

#71

Post by stuntkite »

shpongled wrote: post #65
stuntkite wrote: post #29

Earlier quoted context omitted.

Interesting. I have watched nearly all of The Thought Emporium’s videos (so clearly I’m an expert, lol) and I think he uses the term plasmid to describe DNA he’s working on in the crazy bio IDE he uses. I think in this instance he applied it to a yeast that he cultured and put into pills and swallowed. He really is doing some neat stuff though. He’s inspired me to do some small bio hacking experiments and it ALMOST m…

Plasmid is the correct term!

I am not being sarcastic when I say thank you for confirming that. If someone didn’t confirm it it would pop back in my head for days, “maaan, you fucked it up and now some other nerds are gonna use the term wrong and that’s really not helping anyone.” heh. Cheers. :)

Re: CRISPR gene-editing breakthrough opens door to treating broad array of diseases

#72

Post by nr2x »

cj wrote: post #70
DoctorNick wrote: post #60

Earlier quoted context omitted.

The record breaking temperatures that I'm suffering in the PNW right now serves as a grim reminder that we won't have much of a future, even with all this cool tech.

It’s not impossible to speculate the possibility that in 50-100 years, climate change could be reversed through a CRISPR-like technology (e.g. something that can be released and replicate in the environment, thereby changing it). Or at the very least, I can see a future where gene editing could relieve your suffering from heat by raising the threshold your body can tolerate :)

At current rates of carbon outlay, there won’t be much of a world left to save in 100 years.

Re: CRISPR gene-editing breakthrough opens door to treating broad array of diseases

#73

Post by dcwardell »

Crazy genetics ideas I would like explored

A modified tree that drops nuts of (nearly) pure graphite or some other form of nondecomposable carbon which we can easily harvest and sequester.

Photosynthesis in humans to supplement our energy consumption. Shoutout to Knights of Sidonia.

I understand the ethical issues surrounding the second one.

Re: CRISPR gene-editing breakthrough opens door to treating broad array of diseases

#74

Post by ProjectArcturis »

cj wrote: post #70
DoctorNick wrote: post #60

Earlier quoted context omitted.

The record breaking temperatures that I'm suffering in the PNW right now serves as a grim reminder that we won't have much of a future, even with all this cool tech.

It’s not impossible to speculate the possibility that in 50-100 years, climate change could be reversed through a CRISPR-like technology (e.g. something that can be released and replicate in the environment, thereby changing it). Or at the very least, I can see a future where gene editing could relieve your suffering from heat by raising the threshold your body can tolerate :)

You want something that replicates in the environment and removes carbon? We have those. They're called "plants."

Re: CRISPR gene-editing breakthrough opens door to treating broad array of diseases

#75

Post by MrDresden »

palijer wrote: post #35

I feel like I missed something, and now everywhere I look we have headlines like this. What's wrong with "CRISPR gene editing shown to cure Transthyretin amyloidosis in patient study" Maybe I'm now one of the old people who doesn't understand new usage of language. But I understand that usage dictates grammar rules, but I feel I missed something.

I believe the metaphore of the inverted pyramid used in journalism plays a part here.

edit: Strike that, hadn't realized that the article title and the HN link differed so much.

Re: CRISPR gene-editing breakthrough opens door to treating broad array of diseases

#76

Post by PixelOfDeath »

cj wrote: post #70
DoctorNick wrote: post #60

Earlier quoted context omitted.

The record breaking temperatures that I'm suffering in the PNW right now serves as a grim reminder that we won't have much of a future, even with all this cool tech.

It’s not impossible to speculate the possibility that in 50-100 years, climate change could be reversed through a CRISPR-like technology (e.g. something that can be released and replicate in the environment, thereby changing it). Or at the very least, I can see a future where gene editing could relieve your suffering from heat by raising the threshold your body can tolerate :)

Looking at the world right now, I hope for the best with that gene therapy against sociopathic billionaires.

Re: CRISPR gene-editing breakthrough opens door to treating broad array of diseases

#77

Post by nr2x »

ProjectArcturis wrote: post #74
cj wrote: post #70

Earlier quoted context omitted.

It’s not impossible to speculate the possibility that in 50-100 years, climate change could be reversed through a CRISPR-like technology (e.g. something that can be released and replicate in the environment, thereby changing it). Or at the very least, I can see a future where gene editing could relieve your suffering from heat by raising the threshold your body can tolerate :)

You want something that replicates in the environment and removes carbon? We have those. They're called "plants."

Even if we reforested every possible area, the current rate of carbon outlay exceeds capacity to absorb.

Well explained in the Economist video: https://youtu.be/EXkbdELr4EQ

Re: CRISPR gene-editing breakthrough opens door to treating broad array of diseases

#78

Post by rolleiflex »

noveltyaccount wrote: post #68
ausbah wrote: post #43

>Doctors infused billions of microscopic structures known as nanoparticles carrying genetic instructions for the CRISPR gene-editor into four patients in London and two in New Zealand. The nanoparticles were absorbed by their livers, where they unleashed armies of CRISPR gene-editors. The CRISPR editor honed in on the target gene in the liver and sliced it, disabling production of the destructive protein. this is one…

Is this a one-time treatment? Does it remove all of the offending genetic material, and then when those cells divide they are cured? Or does it require ongoing treatment?

It’s editing the genes of the cells of the liver, so presumably when those liver cells divide and multiply, the change would also be copied along as well.

What isn’t clear to me is that if this is targeted at the liver cells in particular, or splicing it for every cell in the body. In other words, this could be a germline mutation (passed to children) or it could be a somatic mutation (no change to future children), it depends on how targeted the treatment was.

Re: CRISPR gene-editing breakthrough opens door to treating broad array of diseases

#79

Post by correcthorse123 »

calrueb wrote: post #19

The fact that we can apply these sort of therapies to an adult human who consists of millions upon millions of cells blows my mind. Having the ability to fix our "buggy" genetic code while we are alive is amazing.

I think targetting tbe liver is far easier than most other tissues though, unfortunately.
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