Mozart was deaf and five of his six siblings died young. He was constantly I'll, couldn't figure out how to manage money, was physically deformed and died at the of 35.
https://www.grunge.com/194140/the-tragic-real-life-story-of-...
You have no doubt heard of Stephen Hawking, one of the great minds of our era and seriously physically disabled.
A controversial bit of trivia is that Ashkenazi Jews win a relatively high percentage of Nobel prizes. They also are a population that sees a lot of genetic disorders and no one knows how to really sort out if or how those two things are related.
Genius is defined in part by simply being different. Being different is often reviled.
What is a bad thing in some situations can be a good thing in others. Evolution sorts "good" adaptations from "bad" based on who survives long enough to pass on their genes and this is why Sickle Cell Anemia is common in some populations: It confers a survival advantage to the population as a whole for the gene to proliferate (though it's better for the individual to have only one copy, not two).
There is no clear bright line between disability and "normal people." We all tend to see a loss of various abilities as we age and some studies suggest that most people (around 60 percent) struggle with some ordinary tasks while two thirds of them actively eschew the label disabled.