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Heart inflammation cases in young men higher than expected after mRNA vaccines

reuters.com

31–40 of 415 posts

Re: Heart inflammation cases in young men higher than expected after mRNA vaccines

#31

I think that many people who did not have heart issues before don't know what to look for or how it feels. Personally, I did not know I had palpitations until I googled it later. Similarly, I suspect, that some kids/young adults may have had symptoms but don't report.

That can be covered by double blind tests.

Re: Heart inflammation cases in young men higher than expected after mRNA vaccines

#32

Earlier quoted context omitted.

I had this after COVID in April last year right at the beginning. I suspect it is an immune reaction to the virus not the vaccine itself.

But the Pfizer vaccine doesn't contain any of the virus, unless it's just the immune reaction to the spike protein that causes the problem?

https://blogs.sciencemag.org/pipeline/archives/2021/05/04/sp...

Derek Lowe has a post that discusses this.

In short from what I remember, the vaccine is administered in the deltoid, so most of the spike proteins should remain there. Some may travel throughout the body, but overall it is much much less than a natural infection.

That’s why I’m curious to compare myocarditis rates after vaccination to those after infection, because from what we know, natural infection should result in a higher rate of myocarditis than vaccination.

Re: Heart inflammation cases in young men higher than expected after mRNA vaccines

#33

Earlier quoted context omitted.

Agreed. Context matters here. I'd hate for this to get blown out of proportion like the blood clot issue did, causing massive confidence declines in places all over, especially those struggling to roll out vaccines and keep their COVID cases under control. Obviously, if the numbers are alarming, we must react accordingly.

They are alarming based on the measure of Observed vs. Expected cases. Observed (O) cases in that age group: 283 Expected (E) cases in that age group: 10-102 So at least double the top of the confidence interval, for expected.

but that's out of 13m doses, so ~200 out of 13m. I'm not sure how that compares to the expected harm from catching covid but I imagine the vaccine still ends up massively favourable

Re: Heart inflammation cases in young men higher than expected after mRNA vaccines

#34
post #24

Earlier quoted context omitted.

But the Pfizer vaccine doesn't contain any of the virus, unless it's just the immune reaction to the spike protein that causes the problem?

Maybe having immune system working hard somehow naturally puts strain on cardiovascular systems?

A theory (far from proved, but certainly also nothing I'd consider "disproved") is that the spike protein itself may be dangerous, in which case injecting something into yourself that causes your body to deliberately produce it may not be an unmitigated good.

I don't think we have the data either way to be sure the spike protein is completely harmless, though obviously how dangerous it is is bounded by the fact that many people experience no ill effects. (That is, it obviously can't be super-ultra-deadly, because it's not killing everyone instantly. How dangerous it could possibly be is bounded by the fact that many people have received the vaccine.)

Re: Heart inflammation cases in young men higher than expected after mRNA vaccines

#35
This is based on VAERS data. I encourage the curious to look at this data. I did. I would characterize its quality as so poor that probably no conclusions at all can be drawn from it. And I usually find myself defending the use of noisy and/or small data in similar situations.

Re: Heart inflammation cases in young men higher than expected after mRNA vaccines

#36
post #25

Very interesting given one of the lesser known complications of covid can be myocarditis in otherwise healthy individuals with few or no other covid symptoms. In fact, it’s likely the incidence of covid-induced myocarditis is vastly underreported given it often shows no symptoms and can only reasonably be diagnosed with a cardiac MRI which is not always widely available or advised for less-serious heart conditions. I…

The spike protein causes cellular damage, doesn’t matter if it comes from the vaccine or virus

Re: Heart inflammation cases in young men higher than expected after mRNA vaccines

#37
post #6

The interesting table with absolute numbers is on page 18 of [0]. Expected and observed cases are cases of myocarditis / pericarditis here. Crude rate is the number of cases per 1 million administered doses. Use landscape mode if you are reading this from a mobile device, the table is narrow enough for that. Age group Doses Crude Expected Observed administ. rate cases cases 12–15 yrs 134,041 22.4 0–1 2 16–17 yrs 2,25…

That's about the same rate as clots in AstraZeneca's vaccine.

Re: Heart inflammation cases in young men higher than expected after mRNA vaccines

#38
Slightly off topic, but it is quite interesting that US media very consistently uses "Pfizer" if the news is good and some variant of "Pfizer/Biontec" if the news is bad. The opposite holds of course for the German press, which addresses the vaccine as "Biontec" when the news is good.

Re: Heart inflammation cases in young men higher than expected after mRNA vaccines

#39
post #25

Very interesting given one of the lesser known complications of covid can be myocarditis in otherwise healthy individuals with few or no other covid symptoms. In fact, it’s likely the incidence of covid-induced myocarditis is vastly underreported given it often shows no symptoms and can only reasonably be diagnosed with a cardiac MRI which is not always widely available or advised for less-serious heart conditions. I…

The spike protein causes cellular damage, doesn’t matter if it comes from the vaccine or virus

Yes, but the route in which a vaccination takes place (IM injection into deltoid) should mean that much much less of the spike protein ends up in the heart and lungs vs a natural infection. As well, the overall amount of spike protein in the body will be less.

https://blogs.sciencemag.org/pipeline/archives/2021/05/04/sp...

“Consider what happens when you’re infected by the actual coronavirus. We know now that the huge majority of such infections are spread by inhalation of virus-laden droplets from other infected people, so the route of administration is via the nose and/or lungs, and the cells lining your airway are thus the first ones to get infected. The viral infection process leads at the end to lysis of the the host cell and subsequent dumping of a load of new viral particles – and these get dumped into the cellular neighborhood and into the bloodstream. They then have a clear shot at the endothelial cells lining the airway vasculature, which are the very focus of these two new papers.

Compare this, though, to what happens in vaccination. The injection is intramuscular, not into the bloodstream. That’s why a muscle like the deltoid is preferred, because it’s a good target of thicker muscle tissue without any easily hit veins or arteries at the site of injection. The big surface vein in that region is the cephalic vein, and it’s down along where the deltoid and pectoral muscles meet, not high up in the shoulder. In earlier animal model studies of mRNA vaccines, such administration was clearly preferred over a straight i.v. injection; the effects were much stronger. So the muscle cells around the injection are hit by the vaccine (whether mRNA-containing lipid nanoparticles or adenovirus vectors) while a good portion of the remaining dose is in the intercellular fluid and thus drains through the lymphatic system, not the bloodstream. That’s what you want, since the lymph nodes are a major site of immune response. The draining lymph nodes for the deltoid are going to be the deltoid/pectoral ones where those two muscles meet, and the larger axillary lymph nodes down in the armpit on that side.”

Re: Heart inflammation cases in young men higher than expected after mRNA vaccines

#40
post #4

Can the government present anything in a useful manner? The most important information, i.e. if the young men engaged in heavy sports right after getting the vaccine, is missing. Heavy sports is obviously also dangerous while recovering from the flu. But the disorganized chaotic government presentation doesn't give any useful information.

Be careful criticizing government on HN it will be buried in down votes by the fanatics for whatever party is currently in power.

Please don't break the site guidelines like this. Comments like this are tedious and the perceptions are notoriously in the eye of the beholder.

(No, we don't care if people criticize the government. We care about comment quality and ensuing discussion quality.)

https://news.ycombinator.com/newsguidelines.html

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