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Drug users use a lot of drugs

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Re: Drug users use a lot of drugs

#81

Post by cwkoss »

arthurcolle wrote: post #33
wincy wrote: post #23

Earlier quoted context omitted.

To be clear, 120mg is what he takes first thing in the morning. He takes more throughout the day. I’d guess he takes 500+ in a day.

That is impossible. There is no one someone's heart would be able to take that. I take 60 mg daily of Vyvanse and I'm pretty wired all day. I can't even fathom the effects of that on a human body. Is he like 300 lbs?

500mg/day was the figure cited for heavy users in the OP article.

You're right that 500mg is far into overdose territory for novice users. But, he probably has been using for a long time and has a very high tolerance.

Re: Drug users use a lot of drugs

#82

Post by loves_mangoes »

cwkoss wrote: post #79
loves_mangoes wrote: post #69

Earlier quoted context omitted.

I'll add my anecdote to the pile. I don't use ketamine a lot (it is not very good for headaches, pretty good for dulling a mosquito bite until it fades away naturally, excellent for dancing). I've taken about 1000mg over the course of several months, at irregular intervals. While it is somewhat higher than Scott's 280mg/month, it's not an order of magnitude higher. Certainly nowhere near 90,000mg/month. I can report…

> pretty good for dulling a mosquito bite until it fades away naturally Applied topically? Or in the sense that the anesthetic disassociative effects dull most sensations?

I did try rubbing some crushed powder to the bite, but could not notice any effect before I got impatient. Ketamine on my tongue has an instant numbing effect, but to my knowledge nothing transdermaly.

I took it insufflated, the short duration of action and general anesthesia makes it decently practical.

(Of course it sounds pretty silly to recommend Ketamine for a small everyday itch. But that's what I had on hand, and I happen to dislike mosquitos with a very particular intensity =] )

Re: Drug users use a lot of drugs

#83

Post by whymauri »

cwkoss wrote: post #72
heisenbit wrote: post #54

Drug processing in the body can sometimes be surprising. I learned recently about first pass effect which means the drug heads first to the liver and only what passes through is available to the body. So if one ups the dose and the liver processing is saturated a double dose can deliver much more punch than two single ones. The body has many non-linear features and extrapolating several orders of magnitude is often n…

Yep, this is why "boofing" (intrarectal) dosing has found rising popularity in the 'research chemical' scene over the past couple decades. The liver's effects on drugs is really fascinating. Grapefruit has a chemical that can inactive liver enzymes, so some drug addicts regularly drink grapefruit juice to 'get more bang for their buck'. Plain old black pepper (in large doses) inactivates a different enzyme IIRC. Ther…

>There are also some interesting anecdotal cases of people who claim to have found regimens of essential oils, which when consumed at the right schedule saturate liver enzymes to the extent that otherwise inert substances can produce recreationally psychoactive effects.

Are essential oils literally oils? Because I doubt they can have a metabolic effect due to their size and lipophilicity. My main concern is adsorption. But if they're small and greasy, then they may be promiscuous binders.

Or do the essential oils carry other molecules along?

Edit: I see now that individual oils carry many diverse constituents, including some small-to-medium sized lads. That's a pretty interesting shotgun strategy for controlling your metabolism, lol.

Re: Drug users use a lot of drugs

#84

Post by MagnumOpus »

peanut_worm wrote: post #80
beebeepka wrote: post #64

Earlier quoted context omitted.

You mean amphetamines, not stimulants in general. I've seen people do much worse when they mix this shit with alcohol, the worst offender that is still perfectly legal

What non-amphetemine stimulants are people doing recreationally?

Cocaine? MDMA?

Re: Drug users use a lot of drugs

#85

Post by pixelbro »

Zutano wrote: post #68
abstractbarista wrote: post #42

Earlier quoted context omitted.

Just have to say, a half gram dab is a fat dab . I'm sure some people do vaporize all of that at once. However, even with complete inhalation and 'swishing' it in their lungs, they will be wasting a lot of it on the exhale.

'Swishing' in their lungs? I've never heard of that, how does someone even do that?

I presume he's referring to repeatedly exhaling and inhaling a tiny amount to keep circulating smoke in the lungs without losing any to the air. Can't speak for its effectiveness.

Re: Drug users use a lot of drugs

#86

Post by loves_mangoes »

peanut_worm wrote: post #80
beebeepka wrote: post #64

Earlier quoted context omitted.

You mean amphetamines, not stimulants in general. I've seen people do much worse when they mix this shit with alcohol, the worst offender that is still perfectly legal

What non-amphetemine stimulants are people doing recreationally?

2C-B. Cathinones and other pyrovalerones.

Some people even seem to enjoy absorbing Coffee through their nose.

Re: Drug users use a lot of drugs

#87

Post by Impassionata »

agentwiggles wrote: post #74
Impassionata wrote: post #50

Earlier quoted context omitted.

There's some leaked emails where he plainly states he's chasing that audience. https://web.archive.org/web/20210217195335/https://twitter.c... I wouldn't say he's racist but it's almost worse. He didn't think about how this would go down, which is to say, when you court an audience that has a reputation of being overtly racist, your audience will become more and more racist, driving good people out.

I read through the comments he made in the images attached to those tweets, and I don't personally find what he's saying there to be especially problematic. I certainly don't read anything he's saying there as being motivated by racism, hatred, or alt-right political views. I still really appreciate you backing up your post with a link and the chance to dig into his sources. Thanks for the link.

>I don't personally find what he's saying there to be especially problematic.

And you're right in theory; in theory it's fine to give people a chance to express their opinion. In theory the out-of-mainstream views have some insight that's worth the questionable bits.

But in practice, what Scott Alexander did was cultivate a community of racists. He provided a platform, he provided cover for them.

From a purely consequential point of view Scott Alexander's political writing has been a detriment. Surely no one would consider "My community is well known as a racist gathering spot" a successful outcome.

It's not just the cost of doing business with regard to free speech norms, it's a poor application of free speech norms reproducing basic racism.

Re: Drug users use a lot of drugs

#89

Post by Stevvo »

loves_mangoes wrote: post #86
peanut_worm wrote: post #80

Earlier quoted context omitted.

What non-amphetemine stimulants are people doing recreationally?

2C-B. Cathinones and other pyrovalerones. Some people even seem to enjoy absorbing Coffee through their nose.

Cathinones are amphetamines.

Re: Drug users use a lot of drugs

#90

Post by kaybe »

Alex3917 wrote: post #77
loves_mangoes wrote: post #69

Earlier quoted context omitted.

I'll add my anecdote to the pile. I don't use ketamine a lot (it is not very good for headaches, pretty good for dulling a mosquito bite until it fades away naturally, excellent for dancing). I've taken about 1000mg over the course of several months, at irregular intervals. While it is somewhat higher than Scott's 280mg/month, it's not an order of magnitude higher. Certainly nowhere near 90,000mg/month. I can report…

Yeah I think I gave myself some minor bladder damage just by drinking iced mint tea (since it's such a strong diuretic), so I can't imagine I'd react well to ketamine even in small doses.

Wow, how much did you drink?
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