That's why the fundamental solution to both the ageing problem and space exploration is not biological. Humans are fundamentally adapted to live/reproduce on the oxidizing and wet environment on Earth. Rather than bring out a mini Earth environ each time we go to space, we should start thinking about how we can just bring out our mind. It would be much more sustainable in the long run, maybe even on Earth itself.
Expanding beyond that lush environment needed technology. Even flintstone and animal hides are a technology.
Expanding to space needs better technology, but the first step was done when some of our ape-like ancestors bashed an antelope's skull with a rock.