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Antibody levels highly predictive of immune protection from symptomatic Covid

nature.com

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Re: Antibody levels highly predictive of immune protection from symptomatic Covid

#41

Post by [deleted] »

rgbbtc4life wrote: post #9
grej wrote: post #7

Earlier quoted context omitted.

I don’t believe this is clear at all. So far, it actually seems the mRNA vaccines as well as the viral vector vaccines greatly attenuate the severity of COVID among those who do catch a variant.

There is only one study to estimate the effectiveness of the mrna vaccines. It was quite small, and performed only on those who received pristine mrna injections. It's come out that the mass produced vaccine has significant mrna degradation. It's unclear how many people's vaccines were even effective. Additionally you have 9 Yankees players who were fully vaccinated contracting the virus, so its not 95% effective in…

[deleted]

Re: Antibody levels highly predictive of immune protection from symptomatic Covid

#42

Post by belltaco »

christkv wrote: post #28
PeterHolzwarth wrote: post #6

Earlier quoted context omitted.

I believe the paper indicates otherwise, in regards to immunity. To help make sense of the paper, I read this Science Daily article that reviews it, and contains some comments from the paper's authors. https://www.sciencedaily.com/releases/2021/05/210517105727.h... Here, one of the people associated with the paper mentions: "Vaccination works very well to prevent both symptoms and severe disease in the short to mediu…

So it will become endemic and be one of the common colds ?

Not if a significant fraction refuses to get vaccinated.

Re: Antibody levels highly predictive of immune protection from symptomatic Covid

#43

Post by standardUser »

rgbbtc4life wrote: post #5

The people achieving immunity through vaccination are at a huge disadvantage compared to those with natural immunity. As shown in research from the other day, natural antibodies target several proteins and more of the spike protein than Pfizer immunity does. Additionally, natural immunity stimulates both the innate immune response and killer T cell response. I wouldn't be surprised if we start seeing ADE among vaccin…

"It's come out the CDC is performing PCR testing for vaccinated individuals with a lower cycle count than for the unvaccinated."

Do you have anything to back up this conspiracy theory? I'm also wondering how many of the ~1 million tests per day are being performed by the CDC itself?

Re: Antibody levels highly predictive of immune protection from symptomatic Covid

#45

Post by PeterHolzwarth »

christkv wrote: post #28
PeterHolzwarth wrote: post #6

Earlier quoted context omitted.

I believe the paper indicates otherwise, in regards to immunity. To help make sense of the paper, I read this Science Daily article that reviews it, and contains some comments from the paper's authors. https://www.sciencedaily.com/releases/2021/05/210517105727.h... Here, one of the people associated with the paper mentions: "Vaccination works very well to prevent both symptoms and severe disease in the short to mediu…

So it will become endemic and be one of the common colds ?

I feel this depends on what we mean when we say "common cold."

I perceive the topic as characterized by answers to the questions of:

1. How easily can I catch the virus?

2. How likely am I to experience severe symptoms when infected?

3. Are there treatments that will significantly help me if I experience severe symptoms?

My readings indicate covid appears to be more infectious than influenza, but I do not know the comparison between the common cold viruses and covid on this front.

I am uncertain if covid is more or less likely to cause severe symptoms vs influenza. I believe, however, that the viruses that represent the common cold (rhinoviruses) can be definitely characterized as being much more benign in regards to symptoms.

I feel a key issue is #3 - there are few known compounds that can reliably aid in treatment of someone who is experiencing severe symptoms for covid. This is an area of rapidly expanding research now, of course.

Re: Antibody levels highly predictive of immune protection from symptomatic Covid

#46

Post by inter_netuser »

xiphias2 wrote: post #2

My father tested negative for spike specific antibodies 2 weeks after the 2nd Pfizer vaccine (he's not the only one), and as I didn't find any data on people who test negative (and I know that the vaccine has 94% efficiency preventing COVID), he's still mostly not leaving his apartment. He'll have a test against the viruses themselves next week, but he'll need to wait 2 weeks for the result for that test.

Has he been tested for immune deficiencies? What is his age? Have a contact that's an NIH immunologist, want to get his opinion.

tia

Re: Antibody levels highly predictive of immune protection from symptomatic Covid

#47

Post by guscost »

PeterHolzwarth wrote: post #45
christkv wrote: post #28

Earlier quoted context omitted.

So it will become endemic and be one of the common colds ?

I feel this depends on what we mean when we say "common cold." I perceive the topic as characterized by answers to the questions of: 1. How easily can I catch the virus? 2. How likely am I to experience severe symptoms when infected? 3. Are there treatments that will significantly help me if I experience severe symptoms? My readings indicate covid appears to be more infectious than influenza, but I do not know the co…

> I believe, however, that the viruses that represent the common cold (rhinoviruses) can be definitely characterized as being much more benign in regards to symptoms.

There are at least four endemic cold-coronaviruses, plus the adenovirus family, plus a bunch more. The severity of most of these respiratory infections depend a lot on patient comorbidities, and immune history.

Re: Antibody levels highly predictive of immune protection from symptomatic Covid

#48

Post by timr »

PeterHolzwarth wrote: post #45
christkv wrote: post #28

Earlier quoted context omitted.

So it will become endemic and be one of the common colds ?

I feel this depends on what we mean when we say "common cold." I perceive the topic as characterized by answers to the questions of: 1. How easily can I catch the virus? 2. How likely am I to experience severe symptoms when infected? 3. Are there treatments that will significantly help me if I experience severe symptoms? My readings indicate covid appears to be more infectious than influenza, but I do not know the co…

The OP asked a simple question that requires no definitional equivocation. You are complicating the question unnecessarily.

The question is: will the virus become endemic. The simple answer is "yes", because it is already endemic: it has multiple mammalian reservoirs, is found in every country on earth, and is ubiquitous in the human population. It is endemic.

Theories about severity, treatment, etc., are completely irrelevant.

Re: Antibody levels highly predictive of immune protection from symptomatic Covid

#49

Post by verdverm »

_coveredInBees wrote: post #40
atty wrote: post #27

Earlier quoted context omitted.

This is incorrect - from population studies, we now know that both the mRNA vaccines reduce infection rates and reduce severity of symptoms for those who do get infected. In fact, they both show about 90% efficacy at preventing infection at all. That number is probably trending down a bit with all the new strains, but it is still very high.

The Yankee players all had J&J vaccines, so not the mRNA variety.

https://www.cnn.com/2021/05/20/health/yankees-covid-19-break...

The Yankees are reported to be using the J&J vaccine, which is a viral vector product.

Re: Antibody levels highly predictive of immune protection from symptomatic Covid

#50

Post by anamexis »

timr wrote: post #48
PeterHolzwarth wrote: post #45

Earlier quoted context omitted.

I feel this depends on what we mean when we say "common cold." I perceive the topic as characterized by answers to the questions of: 1. How easily can I catch the virus? 2. How likely am I to experience severe symptoms when infected? 3. Are there treatments that will significantly help me if I experience severe symptoms? My readings indicate covid appears to be more infectious than influenza, but I do not know the co…

The OP asked a simple question that requires no definitional equivocation. You are complicating the question unnecessarily. The question is: will the virus become endemic. The simple answer is "yes", because it is already endemic : it has multiple mammalian reservoirs, is found in every country on earth, and is ubiquitous in the human population. It is endemic. Theories about severity, treatment, etc., are completely…

And the second half of the question is "and be one of the common colds," which is exactly what GP was responding to..
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