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Antibody levels highly predictive of immune protection from symptomatic Covid

nature.com

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Re: Antibody levels highly predictive of immune protection from symptomatic Covid

#11

Post by rgbbtc4life »

bandyaboot wrote: post #10
rgbbtc4life wrote: post #5

The people achieving immunity through vaccination are at a huge disadvantage compared to those with natural immunity. As shown in research from the other day, natural antibodies target several proteins and more of the spike protein than Pfizer immunity does. Additionally, natural immunity stimulates both the innate immune response and killer T cell response. I wouldn't be surprised if we start seeing ADE among vaccin…

Do you have a link to the research you’re citing from the other day? Also the basis for your implication that there’s a known difference in T cell response for natural immunity vs vaccine immunity?

Natural antibodies target several proteins: https://directorsblog.nih.gov/2021/05/18/human-antibodies-ta...

Natural immunity robust and long lasting: https://www.nytimes.com/2020/11/17/health/coronavirus-immuni...

Killer t cell importance: https://www.nature.com/articles/d41586-021-00367-7

Re: Antibody levels highly predictive of immune protection from symptomatic Covid

#12

Post by rgbbtc4life »

xiphias2 wrote: post #2

My father tested negative for spike specific antibodies 2 weeks after the 2nd Pfizer vaccine (he's not the only one), and as I didn't find any data on people who test negative (and I know that the vaccine has 94% efficiency preventing COVID), he's still mostly not leaving his apartment. He'll have a test against the viruses themselves next week, but he'll need to wait 2 weeks for the result for that test.

If the vaccine is truly 95% effective in preventing infection, how did 9 fully vaccinated Yankees players all contract the virus?

Re: Antibody levels highly predictive of immune protection from symptomatic Covid

#13

Post by t-writescode »

rgbbtc4life wrote: post #5

The people achieving immunity through vaccination are at a huge disadvantage compared to those with natural immunity. As shown in research from the other day, natural antibodies target several proteins and more of the spike protein than Pfizer immunity does. Additionally, natural immunity stimulates both the innate immune response and killer T cell response. I wouldn't be surprised if we start seeing ADE among vaccin…

How does your argument here correspond with the numerous articles discussing how the mRNA vaccines are effective against the numerous variants?

There's a big scare every time there's a new variant, followed by another article a couple weeks later about how the vaccine is X > 50% effective against [ new variant ].

Re: Antibody levels highly predictive of immune protection from symptomatic Covid

#14

Post by t-writescode »

rgbbtc4life wrote: post #9
grej wrote: post #7

Earlier quoted context omitted.

I don’t believe this is clear at all. So far, it actually seems the mRNA vaccines as well as the viral vector vaccines greatly attenuate the severity of COVID among those who do catch a variant.

There is only one study to estimate the effectiveness of the mrna vaccines. It was quite small, and performed only on those who received pristine mrna injections. It's come out that the mass produced vaccine has significant mrna degradation. It's unclear how many people's vaccines were even effective. Additionally you have 9 Yankees players who were fully vaccinated contracting the virus, so its not 95% effective in…

The Yankees were given the J&J vaccine, not an mRNA vaccine. https://edition.cnn.com/2021/05/13/sport/yankees-test-positi...

Are you scared? Or intentionally spreading misinformation?

Re: Antibody levels highly predictive of immune protection from symptomatic Covid

#16

Post by xiphias2 »

tdeck wrote: post #3
xiphias2 wrote: post #2

My father tested negative for spike specific antibodies 2 weeks after the 2nd Pfizer vaccine (he's not the only one), and as I didn't find any data on people who test negative (and I know that the vaccine has 94% efficiency preventing COVID), he's still mostly not leaving his apartment. He'll have a test against the viruses themselves next week, but he'll need to wait 2 weeks for the result for that test.

How did he happen to get that antibody test?

A nurse came to his apartment to take the test (I payed for it)

Re: Antibody levels highly predictive of immune protection from symptomatic Covid

#17

Post by verdverm »

rgbbtc4life wrote: post #12
xiphias2 wrote: post #2

My father tested negative for spike specific antibodies 2 weeks after the 2nd Pfizer vaccine (he's not the only one), and as I didn't find any data on people who test negative (and I know that the vaccine has 94% efficiency preventing COVID), he's still mostly not leaving his apartment. He'll have a test against the viruses themselves next week, but he'll need to wait 2 weeks for the result for that test.

If the vaccine is truly 95% effective in preventing infection, how did 9 fully vaccinated Yankees players all contract the virus?

1. It was a single player, the rest were other staff

2. Vaccines don't prevent infection, they reduce severity by training the body's immune system. Natural exposure works the same way. This it is not surprising that 8/9 Yankees which tested positive were asymptomatic

Re: Antibody levels highly predictive of immune protection from symptomatic Covid

#18

Post by [deleted] »

rgbbtc4life wrote: post #5

The people achieving immunity through vaccination are at a huge disadvantage compared to those with natural immunity. As shown in research from the other day, natural antibodies target several proteins and more of the spike protein than Pfizer immunity does. Additionally, natural immunity stimulates both the innate immune response and killer T cell response. I wouldn't be surprised if we start seeing ADE among vaccin…

[deleted]

Re: Antibody levels highly predictive of immune protection from symptomatic Covid

#19

Post by bandyaboot »

rgbbtc4life wrote: post #11
bandyaboot wrote: post #10

Earlier quoted context omitted.

Do you have a link to the research you’re citing from the other day? Also the basis for your implication that there’s a known difference in T cell response for natural immunity vs vaccine immunity?

Natural antibodies target several proteins: https://directorsblog.nih.gov/2021/05/18/human-antibodies-ta... Natural immunity robust and long lasting: https://www.nytimes.com/2020/11/17/health/coronavirus-immuni... Killer t cell importance: https://www.nature.com/articles/d41586-021-00367-7

That antibody research doesn’t seem to support your initial assertion of vaccinated individuals being at a huge disadvantage compared to those with natural immunity. Your point about T cell response seems reasonable. A natural T cell response may be able to target internal viral proteins. But backing up a bit, I’m struggling to find the overall “so what”. If a person is worried about getting covid and doesn’t want to be at a “disadvantage” they should...get covid?

Re: Antibody levels highly predictive of immune protection from symptomatic Covid

#20

Post by legobmw99 »

rgbbtc4life wrote: post #12
xiphias2 wrote: post #2

My father tested negative for spike specific antibodies 2 weeks after the 2nd Pfizer vaccine (he's not the only one), and as I didn't find any data on people who test negative (and I know that the vaccine has 94% efficiency preventing COVID), he's still mostly not leaving his apartment. He'll have a test against the viruses themselves next week, but he'll need to wait 2 weeks for the result for that test.

If the vaccine is truly 95% effective in preventing infection, how did 9 fully vaccinated Yankees players all contract the virus?

I think most ball players got J&J, which has a decently lower prevention number. The encouraging news was that they all ended up asymptomatic, which is the next best thing
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