Antibody levels highly predictive of immune protection from symptomatic Covid
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Re: Antibody levels highly predictive of immune protection from symptomatic Covid
#2He'll have a test against the viruses themselves next week, but he'll need to wait 2 weeks for the result for that test.
Re: Antibody levels highly predictive of immune protection from symptomatic Covid
#3My father tested negative for spike specific antibodies 2 weeks after the 2nd Pfizer vaccine (he's not the only one), and as I didn't find any data on people who test negative (and I know that the vaccine has 94% efficiency preventing COVID), he's still mostly not leaving his apartment. He'll have a test against the viruses themselves next week, but he'll need to wait 2 weeks for the result for that test.
Re: Antibody levels highly predictive of immune protection from symptomatic Covid
#4> The estimated neutralization level for protection from severe infection is approximately sixfold lower than the level required to protect from any symptomatic infection. Thus, a higher level of protection against severe infection is expected for any given level of vaccine efficacy against mild SARS-CoV-2 infection. Assuming that this relationship remains constant over time, it appears probable that immunity to severe infection may be much more durable than overall immunity to any infection. Long-term studies of antibody responses to vaccinia, measles, mumps or rubella suggest that these responses generally stabilize with half-lives of >10 years. We therefore projected beyond the reported decay of SARS-CoV-2 responses (out to 8 months after infection5), assuming that after 8 months following the infection the decay rate will slow down. We modeled the decay rate of the neutralization titer, assuming that it slowed linearly to a 10-year half-life over 1, 1.5 or 2 years (details in Methods). This analysis predicts that even without immune boosting, a significant proportion of individuals may maintain long-term protection from severe infection by an antigenically similar strain, even though they may become susceptible to mild infection (Fig. 3b,c).
Sounds like good news. This study appears to be saying that the vaccines do a 6x better job of preventing severe covid infection than the known 94% efficacy preventing even mild symptoms from appearing, and that long term immunity [0] might be expected to last decades, similar to other vaccines.
[0], EDIT: "long term protection against severe sickness", as opposed to "immunity", as pointed out by PeterHolzwarth in comment below
Re: Antibody levels highly predictive of immune protection from symptomatic Covid
#5I wouldn't be surprised if we start seeing ADE among vaccinated individuals - there's a good chance their antibodies will be non neutralizing when challenged with live virus a year from now.
Also, it appears governments are motivated to hide information about the vaccine. It's come out the CDC is performing PCR testing for vaccinated individuals with a lower cycle count than for the unvaccinated. There's no reason to trust anything coming out of the CDC with regards to vaccination.
Re: Antibody levels highly predictive of immune protection from symptomatic Covid
#6From the article, a section called "Prediction of the potential for long term protection" at the bottom of the Results: > The estimated neutralization level for protection from severe infection is approximately sixfold lower than the level required to protect from any symptomatic infection. Thus, a higher level of protection against severe infection is expected for any given level of vaccine efficacy against mild SAR…
https://www.sciencedaily.com/releases/2021/05/210517105727.h...
Here, one of the people associated with the paper mentions:
"Vaccination works very well to prevent both symptoms and severe disease in the short to medium term, but efficacy is predicted to decline over the first few months for most of these vaccines,"
"However, it is very important to understand the difference between immunity against infection and protection from developing severe disease. Our study found that a 6-fold lower level of antibodies is required to protect against severe disease. So even though our analysis predicts that we will start losing immunity to mild infection in the first year after vaccination, protection from severe infection should be longer lived," says Dr Khoury.
Key is that distinction between immunity and protection against severe sickness.
Re: Antibody levels highly predictive of immune protection from symptomatic Covid
#7The people achieving immunity through vaccination are at a huge disadvantage compared to those with natural immunity. As shown in research from the other day, natural antibodies target several proteins and more of the spike protein than Pfizer immunity does. Additionally, natural immunity stimulates both the innate immune response and killer T cell response. I wouldn't be surprised if we start seeing ADE among vaccin…
Re: Antibody levels highly predictive of immune protection from symptomatic Covid
#8The people achieving immunity through vaccination are at a huge disadvantage compared to those with natural immunity. As shown in research from the other day, natural antibodies target several proteins and more of the spike protein than Pfizer immunity does. Additionally, natural immunity stimulates both the innate immune response and killer T cell response. I wouldn't be surprised if we start seeing ADE among vaccin…
Re: Antibody levels highly predictive of immune protection from symptomatic Covid
#9The people achieving immunity through vaccination are at a huge disadvantage compared to those with natural immunity. As shown in research from the other day, natural antibodies target several proteins and more of the spike protein than Pfizer immunity does. Additionally, natural immunity stimulates both the innate immune response and killer T cell response. I wouldn't be surprised if we start seeing ADE among vaccin…
I don’t believe this is clear at all. So far, it actually seems the mRNA vaccines as well as the viral vector vaccines greatly attenuate the severity of COVID among those who do catch a variant.
It's come out that the mass produced vaccine has significant mrna degradation. It's unclear how many people's vaccines were even effective.
Additionally you have 9 Yankees players who were fully vaccinated contracting the virus, so its not 95% effective in preventing infection and there's a very real risk of Merek's disease as a result.
Furthermore, Pfizer is on record as saying a 3rd dose will be needed. Meanwhile, natural immunity has been shown to be robust and long lasting.
Re: Antibody levels highly predictive of immune protection from symptomatic Covid
#10The people achieving immunity through vaccination are at a huge disadvantage compared to those with natural immunity. As shown in research from the other day, natural antibodies target several proteins and more of the spike protein than Pfizer immunity does. Additionally, natural immunity stimulates both the innate immune response and killer T cell response. I wouldn't be surprised if we start seeing ADE among vaccin…