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How I learned to stop worrying and love the lab-leak theory

donaldgmcneiljr1954.medium.com

241–250 of 255 posts

Re: How I learned to stop worrying and love the lab-leak theory

#241

Earlier quoted context omitted.

I agree that the CCP's incentives are to oppose such an investigation regardless of the true origin, especially after they've spent months digging in to that position. But if our goal is to reduce the risk of future pandemics, then do you have a better idea for a policy action to achieve that?

Yes. That's why I'm pointing it out. People get Big Mad at China over the lab leak theory. I'm quite annoyed at China over deflecting investigation of the zoonotic origins because we're risking SARS-3 more or less. But the people yelling about the lab leak hypothesis are also useful idiots in deflecting investigation of the zoonotic origins, so I'm equally annoyed at them. It wasn't a lab leak. We aren't going to do…

So what policy action are you proposing? In other words, what do you think voters should push the American government (or whatever government you elect, assuming you live in a democracy) to do?

If you believe that a lab accident is so unlikely as to not be worth investigating further, then your position is rapidly becoming as fringe as the opposite was four months ago--you disagree here with Tedros, Redfield, Baltimore, Baric, any quote I've seen anywhere from the intelligence community, and many other big names. But if that's your sincere belief, why wouldn't you push for a forensic investigation of natural origin (e.g., allowing scientists not permanently under the CCP's physical control to collect samples from agricultural sites, and ship them out under seal for testing outside China)?

Finally, just for my curiosity: Do you agree with the consensus that the 1977 flu pandemic (which killed ~700k people) was probably a lab accident? Or do you think that one was definitely natural too?

Re: How I learned to stop worrying and love the lab-leak theory

#242
post #177

FWIW I'm going to defer to the virology experts on this one. I know when I am out of my depth, and when to seek expert advise. https://twitter.com/angie_rasmussen/status/13942570285586391...

Angela Rasmussen is indeed a virologist and is heavily quoted in the media, but this appears to be more because she specifically seeks that (she has a publicist!) than due to any prior distinction. Ralph Baric invented modern coronavirology. He was Zhengli Shi's mentor, and published frequently with her in the past. He signed Jesse Bloom's and Alina Chan's letter in Science calling for further investigation of the or…

> Ralph Baric invented modern coronavirology. He was Zhengli Shi's mentor, and published frequently with her in the past. He signed Jesse Bloom's and Alina Chan's letter in Science calling for further investigation of the origins of SARS-CoV-2:

I read the Science article; the way it was drafted doesn't really specifically rule any particular thing out however. It's just calling for a further investigation, and says that both hypotheses remain "viable", which is an extremely low bar in science.

Combing Jasnah's thread with another by Andersen (https://twitter.com/K_G_Andersen/status/1391507230848032772), it paints a picture that any explicit engineering seems a bit far fetched. I have yet to seen any specific responses to these critiques of lab engineered FCN site hypothesis. Instead, I see mountains of people who are not in a position to critically evaluate these claims. Science is both an institution and a process, and not everyone is equally qualified to evaluate the evidence.

Re: How I learned to stop worrying and love the lab-leak theory

#243
post #242

Earlier quoted context omitted.

Angela Rasmussen is indeed a virologist and is heavily quoted in the media, but this appears to be more because she specifically seeks that (she has a publicist!) than due to any prior distinction. Ralph Baric invented modern coronavirology. He was Zhengli Shi's mentor, and published frequently with her in the past. He signed Jesse Bloom's and Alina Chan's letter in Science calling for further investigation of the or…

> Ralph Baric invented modern coronavirology. He was Zhengli Shi's mentor, and published frequently with her in the past. He signed Jesse Bloom's and Alina Chan's letter in Science calling for further investigation of the origins of SARS-CoV-2: I read the Science article; the way it was drafted doesn't really specifically rule any particular thing out however. It's just calling for a further investigation, and says t…

That letter may seem perfectly tepid and reasonable out of context, but Andersen has publicly criticized it:

> But, “the letter suggests a false equivalence between the lab escape and natural origin scenarios,” he said. “To this day, no credible evidence has been presented to support the lab leak hypothesis, which remains grounded in speculation.”

https://www.nytimes.com/2021/05/13/science/virus-origins-lab...

Dr. Shi too (though she obviously can't deviate from the CCP's position without putting herself in physical danger):

> The chief scientist for emerging disease at the Wuhan Institute of Virology, Shi Zhengli, said in an email that the letter’s suspicions were misplaced and would damage the world’s ability to respond to pandemics. “It’s definitely not acceptable,” Shi said of the group’s call to see her lab’s records. "Who can provide an evidence that does not exist?"

https://www.technologyreview.com/2021/05/13/1024866/investig...

The controversy isn't "people who don't think lab origin merits further investigation" vs. "people who don't think natural origin merits further investigation". It's between people who think lab origin is so unlikely that no further investigation of that possibility is necessary (like Andersen and Rasmussen, along with the CCP), vs. people who think both possibilities are sufficiently likely that further investigation of both is required (like Chan, Bloom, Baric, Tedros, Redfield, etc.), as expressed in that letter. I'm obviously with the latter group. For example, I believe we should push China to release more records from the WIV, but I also believe we should keep sampling animals looking for a natural intermediate host. If you study the evidence yourself then I believe you will agree.

As I noted above, as best I can tell the FCS is mostly a distraction--interesting, but not determinative either way. (Although again, a Nobel prize winner seems to disagree with me.) I'm much more convinced by the origin city and distinctive nature of the WIV's work sampling novel viruses from nature, by the lack of an intermediate host, by China's removal of access to the WIV's database of viral genomes in September 2019, by their blocking reporters from the mine where RaTG13 was discovered, and other such non-genomic evidence. This evidence is also much easier to judge without advanced scientific background.

ETA: And for emphasis, "no genetic engineering" also doesn't imply "no lab origin". For example, it's entirely possible that SARS-CoV-2 is a naturally-evolved virus accidentally released by the WIV. They routinely sampled remote, virus-rich bat caves that no other human would enter, with nothing more than a surgical mask and nitrile gloves. They could easily have brought a virus back to Wuhan and released it before even sequencing it, whether in a lab accident there or in a researcher who became infected in the field. I urge you to research and understand this yourself, instead of deferring to strawmen set up by virologists with little distinction beyond their Twitter following.

ETA2: And note that Andersen and Rasmussen both now claim to support further investigation, but prior to the Science letter they did not. They also seem to support it only in the abstract, and to shout down any calls for specific actions (e.g., pushing China to release the WIV's virus database). This is a long story; please try to understand it in detail, and don't take any isolated claim from any side at face value.

Re: How I learned to stop worrying and love the lab-leak theory

#244
post #242

Earlier quoted context omitted.

> Ralph Baric invented modern coronavirology. He was Zhengli Shi's mentor, and published frequently with her in the past. He signed Jesse Bloom's and Alina Chan's letter in Science calling for further investigation of the origins of SARS-CoV-2: I read the Science article; the way it was drafted doesn't really specifically rule any particular thing out however. It's just calling for a further investigation, and says t…

That letter may seem perfectly tepid and reasonable out of context, but Andersen has publicly criticized it: > But, “the letter suggests a false equivalence between the lab escape and natural origin scenarios,” he said. “To this day, no credible evidence has been presented to support the lab leak hypothesis, which remains grounded in speculation.” https://www.nytimes.com/2021/05/13/science/virus-origins-lab... Dr. Sh…

Nobel peace prize winners can been frankly weirdly wrong on these topics when they overextend from their own specific domain. Think back to the AIDs crisis, where Peter Duesberg, an award winning molecular biologist, thought that AIDs couldn't possibly be caused by HIV. He was outside of his peer group that came to realize that AIDs is in fact caused by HIV. Experts can be wrong, but that is why science is not just a process, but an institution. Peer review is how we deal with these discrepancies, and "doing your own research" without expert mentorship is not a substantial substitute.

I have a PhD in bioinformatics, and yet I know that my personal expertise (and ability to consume) information about viral engineering is limited. I therefore have to rely on experts, and make a substantial effort to tune my priors to ensure I'm listening to the right sources. A single medium blog from a reporter without any editorial supervision is not an adequate substitute. When I have questions about how to adjust my priors for this subject, I have been in communication with colleagues whose expertise and knowledge are qualified to answer questions. And from all of this, there has been a general consensus from these scientists that while they cannot specifically rule out lab origin hypothesis, there does not even begin to approximate the amount of evidence we need in order to "prove" it. Remember in science we are trying to make claims that are by nature testable- if you cannot test a hypothesis, it's then just pure speculation.

If you want to waste your mental effort on "doing your own research" and making baseless speculation, fine, waste your time. Go off the deep end and find amusement of the sort of baseless conspiracy theory folks that appear on Joe Rogan. But do not for a moment bring baseless speculation into the realm of science. Too many people have spent too much time to waste it on people who cannot intellectually appreciate the differences between testable scientific hypothesis and a baseless speculative claim.

Re: How I learned to stop worrying and love the lab-leak theory

#245
post #235

I think this ignores why the "lab leak" theory was being squashed in public: 1. There was no evidence 2. The conspiracies going around in early days prompting the response was that China manufactured the virus as a weapons and/or released it on purpose. 3. There was no evidence People were reading the WHO reports as information was coming in and they were talking about no transmission outside familial groups and sayi…

No eVIdEnCE is exactly what you would expect to see from a lab leak in China, and the exact opposite of what you would expect in literally any other situation. So it's still no direct evidence, but it is increasingly strong circumstantial evidence.

Re: How I learned to stop worrying and love the lab-leak theory

#246
post #126

So if the lab leak theory turns out to be true, how will people deal with the fact that they've been vehemently disregarding it as a "Q-anon conspiracy theory"? And would it be worth questioning if any other recent topics labeled as "conspiracy theories" may in fact also be true?

This article is already taken care of that hasn't it? 80% of it is spent smearing anyone who knew from the beginning that logically this was overwhelmingly likely to be a lab leak.

Re: How I learned to stop worrying and love the lab-leak theory

#247
post #203
post #170

Earlier quoted context omitted.

Thanks for mentioning the election example. The word “lies” is a proxy for lack of rigorous journalism as well. When journalists claim that opinions / criticism about something as complicated as an election are “lies”, their bias is quite obvious. It’s as if there is no nuance allowed.

In the case of the election, "lies" is a perfectly appropriate word, since the people claiming voter fraud were lying about the possibility of fraud. No fraud was actually found, and everyone investigating found nothing to suggest any fraud was happening or likely. So yes, if you stand up and claim that there was rampant voter fraud that changed the outcome of the election, you are at best misinformed, and at worst l…

Your second paragraph is more reasonable but it is in conflict with the first.

Do you deny as stated by many news agencies that the CIA stated or leaked that Russian agents impacted the 2016 election? What about the 2020 election? Is the CIA lying? Did Russian agents or other hackers just sit that one out?

There is so much evidence of election fraud and odd irregularities throughout the United States … the question is whether there was enough of it to impact the results. Arizona came down to 0.3% of the vote and Georgia was razor thin as well. States like these are decided by how votes are counted in a single county (Fulton and Maricopa in these cases) due to the high population concentration in a region of the state. Questioning the results (regardless of which political party) is not lying especially given the thin margins; it is healthy for democracy and gives more confidence in future election results.

Re: How I learned to stop worrying and love the lab-leak theory

#248
post #244

Earlier quoted context omitted.

That letter may seem perfectly tepid and reasonable out of context, but Andersen has publicly criticized it: > But, “the letter suggests a false equivalence between the lab escape and natural origin scenarios,” he said. “To this day, no credible evidence has been presented to support the lab leak hypothesis, which remains grounded in speculation.” https://www.nytimes.com/2021/05/13/science/virus-origins-lab... Dr. Sh…

Nobel peace prize winners can been frankly weirdly wrong on these topics when they overextend from their own specific domain. Think back to the AIDs crisis, where Peter Duesberg, an award winning molecular biologist, thought that AIDs couldn't possibly be caused by HIV. He was outside of his peer group that came to realize that AIDs is in fact caused by HIV. Experts can be wrong, but that is why science is not just a…

I don't know who you think is asserting that lab origin is "proven"? The claim is that sufficient evidence exists that it should be investigated, not that investigation of all other possibilities should stop.

For a specific example, the WIV had a database of viral genomes, available on the public Internet. There was also a private, password-protected section. That entire database went offline in September 2019, and hasn't come back. The WIV has cited "hacking attempts" as the reason.

Do you find that reason credible? Do you believe that the contents of that database should be obtained and publicly disclosed, for open scientific review? If yes, then you share your desired policy action with the "baseless conspiracy folks". If no, then you share it with the CCP.

And since you say "priors": knowing that a pandemic emerged but nothing else, what's your prior that it emerged due to lab activity? I assume you're aware that the 1977 flu pandemic was probably a lab escape, and depending how you count we've had perhaps a dozen pandemics in the last fifty years; so I don't see how you can claim less than ~5%. That's far from negligible, so what evidence takes you from there to dismissing it as "baseless speculation"? It can't be the novelty of the pathogen, since a distinctive part of the WIV's research was specifically their collection of novel pathogens from nature (about 900 miles away, to be clear; Wuhan wasn't in an expected natural spillover zone).

Re: How I learned to stop worrying and love the lab-leak theory

#249

Earlier quoted context omitted.

I agree that the CCP's incentives are to oppose such an investigation regardless of the true origin, especially after they've spent months digging in to that position. But if our goal is to reduce the risk of future pandemics, then do you have a better idea for a policy action to achieve that?

Yes. That's why I'm pointing it out. People get Big Mad at China over the lab leak theory. I'm quite annoyed at China over deflecting investigation of the zoonotic origins because we're risking SARS-3 more or less. But the people yelling about the lab leak hypothesis are also useful idiots in deflecting investigation of the zoonotic origins, so I'm equally annoyed at them. It wasn't a lab leak. We aren't going to do…

This is the first time I'm seeing the word 'pox' being used by someone! Till now I've only seen it being used in books!

Re: How I learned to stop worrying and love the lab-leak theory

#250

Earlier quoted context omitted.

So one bad flew 2400 kilometers, bit some people in Wuhan, then died? It started in Wuhan spontaneously. There are no intermediary COVID19 infections in a migration trail of any kind from those bat reservoirs in Yunnan to Hubei.

> There are no intermediary COVID19 infections in a migration trail of any kind from those bat reservoirs in Yunnan to Hubei. Can you cite a few other diseases where the evolution was traced back in multiple species across that kind of distance? Where did ebola come from? MERS? At best you get the immediate host, or as with covid a somewhat close relative. You're demanding proof that simply doesn't exist for any othe…

https://pubmed.ncbi.nlm.nih.gov/29669833/

This is a paper from 2018 where they went into caves in southern China and took 1000+ samples of droppings from bats back to Wuhan and found new strains of coronaviruses.

If they did this in late 2019 of course they wouldn't have published that after a (theoretical) leak...an absence of a sample means nothing. In fact, if anything the fact they didn't publish a similar report is more telling.

If you look at pre Covid-19 reports on bat coronoaviruses in China you'll see the large majority of such bats are in Southern China - very far away from Wuhan.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466186/

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