The Achilles Heel of the Coronavirus
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Re: The Achilles Heel of the Coronavirus
#2A bit redundant.
We know how to “kill” the SARS-CoV-2 virus in vitro (in a test tube). Ammonia, bleach, UV light. Heck, even diluted mouthwash will do the trick.
The problem is that none of these approaches are safe in vivo (in the body). All of the approaches the article talks will require years of human testing. The drug EIDD-2801 does similar things but has yet to pass testing even after 12 months of studies.
Re: The Achilles Heel of the Coronavirus
#3A bit redundant. We know how to “kill” the SARS-CoV-2 virus in vitro (in a test tube). Ammonia, bleach, UV light. Heck, even diluted mouthwash will do the trick. The problem is that none of these approaches are safe in vivo (in the body). All of the approaches the article talks will require years of human testing. The drug EIDD-2801 does similar things but has yet to pass testing even after 12 months of studies.
This isn't about "killing" the virus, it's about inhibiting its ability to reproduce. Pointedly, it's about doing so without introducing mutagens like EIDD-2801, but instead by inhibiting a specific ribosomal behavior induced by a component of the virus. Finding a safe mechanism to do so is the next step in their research. I suspect your interpretation of the article might be off.
This work is a great example of the new insights we get from recent advances in cryo-electron microscopy. It's much easier to formulate responses to mechanisms when we can get clear pictures of the sites in question.
Re: The Achilles Heel of the Coronavirus
#4A bit redundant. We know how to “kill” the SARS-CoV-2 virus in vitro (in a test tube). Ammonia, bleach, UV light. Heck, even diluted mouthwash will do the trick. The problem is that none of these approaches are safe in vivo (in the body). All of the approaches the article talks will require years of human testing. The drug EIDD-2801 does similar things but has yet to pass testing even after 12 months of studies.
This isn't about "killing" the virus, it's about inhibiting its ability to reproduce. Pointedly, it's about doing so without introducing mutagens like EIDD-2801, but instead by inhibiting a specific ribosomal behavior induced by a component of the virus. Finding a safe mechanism to do so is the next step in their research. I suspect your interpretation of the article might be off. This work is a great example of the…
Suppose protein folding simulation and manufacturing can rapidly advance well beyond current levels. It seems like a hypothetical synthetic immune system that whitelists every configuration of every protein an individual can possibly generate and excludes everything else (if possible) would be a way to blanket eliminate unknown unknowns proactively like SELinux for the body.
Re: The Achilles Heel of the Coronavirus
#5Trump said UV light, the fucker was right all the time.
Re: The Achilles Heel of the Coronavirus
#6Pretty interesting how well the article explains such a complex concept.
Re: The Achilles Heel of the Coronavirus
#7Earlier quoted context omitted.
This isn't about "killing" the virus, it's about inhibiting its ability to reproduce. Pointedly, it's about doing so without introducing mutagens like EIDD-2801, but instead by inhibiting a specific ribosomal behavior induced by a component of the virus. Finding a safe mechanism to do so is the next step in their research. I suspect your interpretation of the article might be off. This work is a great example of the…
Suppose protein folding simulation and manufacturing can rapidly advance well beyond current levels. It seems like a hypothetical synthetic immune system that whitelists every configuration of every protein an individual can possibly generate and excludes everything else (if possible) would be a way to blanket eliminate unknown unknowns proactively like SELinux for the body.
I did a thought experiment about how the immune system must work and came up with a simple system using only mechanisms that I know are available molecularly.
If you could have a bunch of random protein sensors that undergo a training phase where they learn what "Host" is. Anything that makes a "detection" during training is discarded. Anything that doesn't is either never going to detect stuff, or might detect something "Foreign".
These then float around your blood stream and either do nothing until they are lost, or go crazy replicating and raising the alarm when something Foreign shows up.
A danger with this method is random sequences that are just really bad at detecting "Host" or a training period that is cut short. This might lead to autoimmune responses.
This thought might give some hints about how to combat autoimmune diseases without disrupting the greater immune system.
Re: The Achilles Heel of the Coronavirus
#8A bit redundant. We know how to “kill” the SARS-CoV-2 virus in vitro (in a test tube). Ammonia, bleach, UV light. Heck, even diluted mouthwash will do the trick. The problem is that none of these approaches are safe in vivo (in the body). All of the approaches the article talks will require years of human testing. The drug EIDD-2801 does similar things but has yet to pass testing even after 12 months of studies.
I believe Trump is famous for discovering this and they were going to try how drinking or injecting bleach could be used?
Re: The Achilles Heel of the Coronavirus
#9Earlier quoted context omitted.
Suppose protein folding simulation and manufacturing can rapidly advance well beyond current levels. It seems like a hypothetical synthetic immune system that whitelists every configuration of every protein an individual can possibly generate and excludes everything else (if possible) would be a way to blanket eliminate unknown unknowns proactively like SELinux for the body.
I did a thought experiment about how the immune system must work and came up with a simple system using only mechanisms that I know are available molecularly. If you could have a bunch of random protein sensors that undergo a training phase where they learn what "Host" is. Anything that makes a "detection" during training is discarded. Anything that doesn't is either never going to detect stuff, or might detect somet…
Perhaps an improved auto-recognition "self" system that uses something like public key crypto and a challenge-response.
Re: The Achilles Heel of the Coronavirus
#10For me sounds scary to disable a mechanism in all our cells that is "rarely used".
Negative knowledge covers what we don't know and what we don't know that we don't know, and that rarely could be less rare than we thought, doing maybe not do frequent but anyway essential things, for all or some cells.