Current RNA vaccines protect against worrying coronavirus variants
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Re: Current RNA vaccines protect against worrying coronavirus variants
#2So, then I would assume this means people with antibodies from the initial wave of infections are also protected
Re: Current RNA vaccines protect against worrying coronavirus variants
#3So, then I would assume this means people with antibodies from the initial wave of infections are also protected
Interestingly, the mRNA vaccines produce superior immunity compared to getting infected, due mainly to the two dose regimen. For similarly long-lasting natural immunity you'd probably need to get infected with covid twice.
Re: Current RNA vaccines protect against worrying coronavirus variants
#4So, then I would assume this means people with antibodies from the initial wave of infections are also protected
Not necessarily [1]. COVID vaccines particularly give you far higher neutralization titers than a prior infection.
[1] A glaring counterexample to your hypothesis is Brazil (Manuas) where prior infections (as high as 60%) didn't stop the P1 variant from ripping through.
Re: Current RNA vaccines protect against worrying coronavirus variants
#5So, then I would assume this means people with antibodies from the initial wave of infections are also protected
Not necessarily [1]. COVID vaccines particularly give you far higher neutralization titers than a prior infection. [1] A glaring counterexample to your hypothesis is Brazil (Manuas) where prior infections (as high as 60%) didn't stop the P1 variant from ripping through.
> COVID vaccines particularly give you far higher neutralization titers than a prior infection.
Do you have a source for that?
Re: Current RNA vaccines protect against worrying coronavirus variants
#6So, then I would assume this means people with antibodies from the initial wave of infections are also protected
Interestingly, the mRNA vaccines produce superior immunity compared to getting infected, due mainly to the two dose regimen. For similarly long-lasting natural immunity you'd probably need to get infected with covid twice.
Do you have a source for that?
Re: Current RNA vaccines protect against worrying coronavirus variants
#7Earlier quoted context omitted.
Not necessarily [1]. COVID vaccines particularly give you far higher neutralization titers than a prior infection. [1] A glaring counterexample to your hypothesis is Brazil (Manuas) where prior infections (as high as 60%) didn't stop the P1 variant from ripping through.
> COVID vaccines particularly give you far higher neutralization titers than a prior infection. Do you have a source for that?
Re: Current RNA vaccines protect against worrying coronavirus variants
#8So, then I would assume this means people with antibodies from the initial wave of infections are also protected
Not necessarily [1]. COVID vaccines particularly give you far higher neutralization titers than a prior infection. [1] A glaring counterexample to your hypothesis is Brazil (Manuas) where prior infections (as high as 60%) didn't stop the P1 variant from ripping through.
> glaring counterexample to your hypothesis is Brazil (Manuas) where prior infections (as high as 60%) didn't stop the P1 variant from ripping through
This says nothing about the strength of a previous infection. It very plausibly just says that R > 1.7, ie it is infecting the remaining 40%.
Re: Current RNA vaccines protect against worrying coronavirus variants
#9So, then I would assume this means people with antibodies from the initial wave of infections are also protected
Not necessarily [1]. COVID vaccines particularly give you far higher neutralization titers than a prior infection. [1] A glaring counterexample to your hypothesis is Brazil (Manuas) where prior infections (as high as 60%) didn't stop the P1 variant from ripping through.
> [1] A glaring counterexample to your hypothesis is Brazil (Manuas) where prior infections (as high as 60%) didn't stop the P1 variant from ripping through.
The prior infection estimates for Manaus were simply wrong. They were based on a paper that "adjusted" the observed seroprevalence rates upward by a factor of ~3x. The parsimonious conclusion is that these corrections were too aggressive and ended up over-estimating infections. See Figure 2a in the paper, here:
https://pubmed.ncbi.nlm.nih.gov/33293339/#&gid=article-figur...
It is a "glaring" example only of how the low editorial standards of major journals during this pandemic has led to a wave of confusion amongst the public.
Re: Current RNA vaccines protect against worrying coronavirus variants
#10So, then I would assume this means people with antibodies from the initial wave of infections are also protected
Interestingly, the mRNA vaccines produce superior immunity compared to getting infected, due mainly to the two dose regimen. For similarly long-lasting natural immunity you'd probably need to get infected with covid twice.
There's also the benefit that with the mRNA vaccines (and the adenovirus vaccines as well), your body is developing antibodies specifically for the spike protein, which is highly conserved. Your body's immune response to actual covid may, just by chance, focus on a less strongly conserved target.