Earlier quoted context omitted.
50 jurisdictions, actually. Less considering that some states don't have sales tax and still more aren't going this route.
actually there are far more than 50, as many counties and municipalities have their own sales tax rates on top of their state's rate. not only that, but it is far more complex than just one fixnum per jurisdiction as each is able to establish rules on what is taxed and what is not. the prime example is food, where the local laws on what counts as non-taxed food always seem a bit byzantine.
I'd still note that every single national retailer manages to do it ok.