Do not use Rufus to make Windows 10 install media. Rufus sucks for this purpose. It uses a weird partition scheme and custom bootloader that doesn't work with secure boot. You don't need any of this shit. Partition the drive as NTFS, mark the partition as active through Disk Management, and simply copy and paste the contents of the iso into the drive. For maximum compatibility, just use FAT32 instead of NTFS. The off…
Rufus also tends to format the drive strangely for *nix ISO files also. Last time I used it the write operation failed and I was stuck spending more time than necessary repairing the drive's partitions just to make it visible to my machine again. What compounds this is the documentation which can only be described as condescending and hostile.
If memory serves, there's a section in the documentation's FAQ where the author spends a paragraph first telling you that it's good your having problems with your USB drive since it will teach you a lesson. I can never understand why some documentation writers feel the need to take digs at their users. Very odd.