prions - scary shit.
No evidence of prions so far.
Doctors investigate mystery brain disease in Canada
211–220 of 311 posts
Re: Doctors investigate mystery brain disease in Canada
#212> CJD test came back negative
So a CJD test is usually staining a biopsy with congo red and observing apple-green birefringence in the image. This generally works to detect amyloid plaques, which is common to all prions. So unless there was a lab mistake, the prion is localized elsewhere from where the biopsies are being done (FFI, for example, localizes to a different part of the brain) or they were using some other procedure, it's seems pretty unlikely this is a prion disease.
Re: Doctors investigate mystery brain disease in Canada
#213Earlier quoted context omitted.
Please source the MSG claim. Asians eat huge amounts of MSG and as far as i know there isn't any pandemic like mystery diseases floating around over there. Highly advanced surveillance systems in South Korea, Japan etc. would be more than able to pick up such things.
https://www.honeycolony.com/article/excitotoxins-fda-approve... For some reason my edit immediately after making the post didn’t make it but I meant to include this with a statement “I have no idea about the veracity of this claim or website”. I’m not looking to defending this with one hard but it could be right.
If you have no idea about the veracity of this claim, it's irresponsible to flat-out write "you get plenty of excitotoxins from eating MSG".
Re: Doctors investigate mystery brain disease in Canada
#214Earlier quoted context omitted.
Seems like prions only "infect" the same kind of protein, so a misfolded spike protein that the vaccine might produce would only cause other spike proteins to misfold, and they almost surely don't occur naturally in human tissue so there should be no risk at all.
Excellent explanation I guess the short term effects of producing these proteins is pretty small, that’s good to know.
As I commented below, I have only drawn loose correlations with no direct evidence as well... so to hear the mechanics of prion misfiling other same proteins is much appreciated.
Re: Doctors investigate mystery brain disease in Canada
#215The province of New Brunswick has set up a website tracking this here: https://www2.gnb.ca/content/gnb/en/departments/ocmoh/cdc/neu...
Interesting. The symptoms they list are entirely typical of FND, which accounts more than 1 in 7 referrals to a neurology department and is at least as common as MS [1]. They list 48 active cases, but there would presumably be a lot more FND cases than that in NB. Also, it seems they only uncovered this new syndrome when they actively started looking for them via the Creutzfeldt-Jakob Disease Surveillance System. Could it just be that many doctors and neurologists are unaware of FND, even though it is by far the most common neurological disorder they see?
[1] http://www.rcpe.ac.uk/journal/issue/journal_41_1/stone.pdf
Re: Doctors investigate mystery brain disease in Canada
#216Earlier quoted context omitted.
More people dead of Covid than TBC is not enough in your mind to make it a serious risk? How can you jump to prions (which no other viral disease has ever been known to cause) before simply looking at the massive death toll, despite the unprecedented restrictions?
Perhaps I’m a bit too relative in thinking our threshold for responding to pandemics should be in proportion to the response than previously seen pandemics and events... so here’s what I mean: “Any mortality comparisons between these two pandemics in the United States, 2020 and 1918, must differentiate between totals and rates. The current US population, a little more than 330 million, is more than three times larger…
Why would you compare the death rates from a pandemic that happened immediately following a devastating world war, with famine and poverty all across the globe, at the very beginning of real medicine, in a world of borders; with one happening in 2020 in a globalized world where we have access to much more advanced medical knowledge, and where an outbreak in Wuhan can become an epidemic in New York?
Not to mention, the initial death tolls in the unprepared places, like Lombardia in Italy or Iran, should be motivation enough for a quick and decisive response. Unfortunately, neither the US nor Europe nor Russia were smart enough to take such an approach, and instead of a quick and thorough lockdown + contact tracing that would have hurt daily life for maybe 2 months before back to normal, with almost no casualties (see Vietnam to note that this was entirely possible), we are getting 2 years of lukewarm responses that leave the same order of magnitude of deaths as the 1918 pandemic.
Re: Doctors investigate mystery brain disease in Canada
#217Earlier quoted context omitted.
Perhaps I’m a bit too relative in thinking our threshold for responding to pandemics should be in proportion to the response than previously seen pandemics and events... so here’s what I mean: “Any mortality comparisons between these two pandemics in the United States, 2020 and 1918, must differentiate between totals and rates. The current US population, a little more than 330 million, is more than three times larger…
Why would you compare the death rates from a pandemic that happened immediately following a devastating world war, with famine and poverty all across the globe, at the very beginning of real medicine, in a world of borders; with one happening in 2020 in a globalized world where we have access to much more advanced medical knowledge, and where an outbreak in Wuhan can become an epidemic in New York? Not to mention, th…
That’s a thoughtful discussion, and I hear your points, I’m just keeping a bit of “open weights” to the possibilities.
To your point, we are more medically advanced and can track cell phones across the globe, which in some ideas could mean we need to respond less in an aggressive amputation of economies and more focused proper risk assessments - which also means I would have advocated from the beginning to ground all travel (air esp) and any economic activity to assess the situation for a month or two.
So when evaluating Italy or Iran, we should be doing genetic testing and massive analysis on who gets severe vs mild cases, and is is a heritable trait that could explain anomalies in various communities.
Again, beautiful discussion... not saying you’re wrong, just leaving options open.
Re: Doctors investigate mystery brain disease in Canada
#218I lived in Fredericton for about 7 years and have been around the province a bit. The air in Moncton is definitely unusual. I wouldn't be surprised if it has something to do with it.
Interesting. In what way is the air unusual?
Re: Doctors investigate mystery brain disease in Canada
#219Earlier quoted context omitted.
More people dead of Covid than TBC is not enough in your mind to make it a serious risk? How can you jump to prions (which no other viral disease has ever been known to cause) before simply looking at the massive death toll, despite the unprecedented restrictions?
Perhaps I’m a bit too relative in thinking our threshold for responding to pandemics should be in proportion to the response than previously seen pandemics and events... so here’s what I mean: “Any mortality comparisons between these two pandemics in the United States, 2020 and 1918, must differentiate between totals and rates. The current US population, a little more than 330 million, is more than three times larger…
India is currently at 3.5k deaths _per day_. Anyone who's been paying attention knows that the issue at hand isn't that COVID is some kind of super-disease, but that it causes a strain on emergency medical resources that can quickly cause chaos. Ventilator resources used up, oxygen unavailable, etc.
There's no need to come up with a new conspiracy theory about COVID every day. The facts are way more boring, but it all does ultimately check out.
Re: Doctors investigate mystery brain disease in Canada
#220Earlier quoted context omitted.
Perhaps I’m a bit too relative in thinking our threshold for responding to pandemics should be in proportion to the response than previously seen pandemics and events... so here’s what I mean: “Any mortality comparisons between these two pandemics in the United States, 2020 and 1918, must differentiate between totals and rates. The current US population, a little more than 330 million, is more than three times larger…
India is currently at 3.5k deaths _per day_. Anyone who's been paying attention knows that the issue at hand isn't that COVID is some kind of super-disease, but that it causes a strain on emergency medical resources that can quickly cause chaos. Ventilator resources used up, oxygen unavailable, etc. There's no need to come up with a new conspiracy theory about COVID every day. The facts are way more boring, but it al…
Right on - I would just say fairly early on in this process we knew what Covid did when to who and how, but we didn't adjust the strategy in the US to match the new information. Which left a big gaping 'Why'? (and yes, easily filled in with p < 0.05 possibilities)