Live data from Hacker News

What can mRNA treat next?

qz.com

151–160 of 197 posts

Re: What can mRNA treat next?

#152

What can companies do to ease the public's worry about mRNA vaccines? I work with a number of people who will not get an mRNA vaccine until they are better understood.

The answer seems straightforward then. More research to better understand mRNA vaccines and their consequences plus an effort to communicate what is found in a way that is digestible for lay people.

How much more easily digestible can you get than this?

https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different...

Re: What can mRNA treat next?

#153

Earlier quoted context omitted.

The answer seems straightforward then. More research to better understand mRNA vaccines and their consequences plus an effort to communicate what is found in a way that is digestible for lay people.

How much more easily digestible can you get than this? https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different...

I suppose that gets points for being easily digestible, but it is also from a source that has knowingly lied to the public about covid safety in the past year (masks), it doesn't address any specific concerns related to the vaccine, and this document itself is obviously wrong. For example, it calls the vaccine a "a harmless piece" of mRNA when side-effects to the vaccine that are fairly considered harmful (fever, feeling bad, malaise, etc) are well documented and commonly known.

If they wanted to do a good job, the information should come from a trustworthy source, it should present the best arguments against the vaccine, and discuss the merits and lack thereof of those arguments. It should genuinely present the risks and the benefits and a good analysis of the tradeoffs. This document clearly falls well short.

You can't expect to convince people like this.

Re: What can mRNA treat next?

#154
post #134

Because it's buried in some two thousand words: > helping cells produce tissue to heal from events such as cardiac arrest > beyond simple vaccines [...] mRNA therapeutics might be tailored to instruct a person’s immune system to fight their specific type of cancer, or target protein deficiencies in specific organs, and without the toxic side effects of traditional medications. > “My personal moonshot is snake venom,…

Thank you for the summary. We know we're deep in the weeds when heart disease and cancer are the afterthoughts among candidate diseases to treat.

Re: What can mRNA treat next?

#155
post #134

Because it's buried in some two thousand words: > helping cells produce tissue to heal from events such as cardiac arrest > beyond simple vaccines [...] mRNA therapeutics might be tailored to instruct a person’s immune system to fight their specific type of cancer, or target protein deficiencies in specific organs, and without the toxic side effects of traditional medications. > “My personal moonshot is snake venom,…

I think another key takeaway is that mRNA didn't really seem to interest anyone until the pandemic came along.

Re: What can mRNA treat next?

#156
post #134

Because it's buried in some two thousand words: > helping cells produce tissue to heal from events such as cardiac arrest > beyond simple vaccines [...] mRNA therapeutics might be tailored to instruct a person’s immune system to fight their specific type of cancer, or target protein deficiencies in specific organs, and without the toxic side effects of traditional medications. > “My personal moonshot is snake venom,…

Yes, thanks for that. I seem to not even be able to access the article.

Re: What can mRNA treat next?

#157
post #134

Because it's buried in some two thousand words: > helping cells produce tissue to heal from events such as cardiac arrest > beyond simple vaccines [...] mRNA therapeutics might be tailored to instruct a person’s immune system to fight their specific type of cancer, or target protein deficiencies in specific organs, and without the toxic side effects of traditional medications. > “My personal moonshot is snake venom,…

Yes, thanks for that. I seem to not even be able to access the article.

Here you go: https://archive.is/LPONQ

Re: What can mRNA treat next?

#158
post #75

Scientifically and medically, vaccines seem extraordinarily exciting as a simple tool that can permanently eliminate problems. Treatments sound very exciting if I were running a business, but scientifically less so. I'm really glad that we've developed these great mRNA vaccines, and I hope that a business drive for recurring revenue doesn't chase people back to merely looking for treatments.

Permanently? I thought the standard of performance has become “reducing symptoms, maybe, we think, we’re not really sure. This is probably safe though”

True for anti-depressants. Evidence is extremely weak and the large majority of the effect in anyone below severe depression is known to be placebo.

Re: What can mRNA treat next?

#159
post #157

Earlier quoted context omitted.

Yes, thanks for that. I seem to not even be able to access the article.

Here you go: https://archive.is/LPONQ

Thank you very much. I found one I inferred from the above quotes but wasn't listed:

Rossi was instead interested in using mRNA technology to treat rare genetic diseases which couldn’t be cured by other means.

And I'm not done reading. I just know something about genetic disorders and the stuff about proteins hinted at this possiblity in my mind.

Re: What can mRNA treat next?

#160
> Derrick Rossi doesn’t quite see it this way, but he kind of saved the world. > > In 2008, he began researching messenger RNA (mRNA), building on the long-ignored work of Hungarian researcher Katalin Karikó

What?! Katalin Karikó is an SVP at BioNTech, the lab that created Pfizer's vaccine.

Post reply on HN