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SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2

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Re: SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2

#81

Post by nradov »

podgaj wrote: post #79
nradov wrote: post #75

Earlier quoted context omitted.

Zinc supplements are part of the recommended prevention and treatment protocol. There is some research to indicate that Quercetin facilities zinc uptake. https://covid19criticalcare.com/covid-19-protocols/i-mask-pl...

Yeah yeah yeah, but why isn’t this been blasted with the public airwaves, especially in India? Plus, they’re giving zinc to people already sick. Why not check people for zinc deficiency and supply them with the zinc they need? I know why, it’s because we don’t believe in preventative care in this country.

Yes it is disappointing how public health authorities have focused almost entirely on exposure prevention. There should be equal focus on harm reduction for people who do get exposed.

Re: SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2

#82

Post by podgaj »

TheAdamAndChe wrote: post #6
unanswered wrote: post #3

If this is a function of the spike protein, doesn't that mean the mRNA vaccines cause this effect as well?

The spike protein from the virus bands to ACE2 receptor, messing them up. The vaccine primes our bodies to attack the spike protein, preventing it from binding to ACE2 and thus preventing it from messing up ACE2 receptors.

No idea why this is being downvoted. This is exactly what happens. But the virus destroys ACE2 (not the "reception because there is no ACE2 receptor. ACE2 is an enzyme).

Re: SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2

#83

Post by podgaj »

Godel_unicode wrote: post #34
beagle3 wrote: post #21

Earlier quoted context omitted.

Indeed. But it's a nontrivial question of numbers. The vaccine has to be orders of magnitude safer than the virus, because (essentially) everyone will get the vaccine, but only some will get the disease. E.g. it might be harmful to vaccinate people in New Zealand and Australia at this point, because for now they cannot get the virus. What these papers (there are 3 independent ones showing very similar results, all co…

Myocarditis is significantly under-diagnosed in young adults, but is believed to be on the order of 10 cases per 100,00 per year in the population.

Zinc deficiency and cellular oxidative stress: prognostic implications in cardiovascular diseases https://www.nature.com/articles/aps201825 Supplementing zinc can reduce the risk of atherosclerosis and protect against myocardial infarction and ischemia/reperfusion injury.

Re: SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2

#84

Post by sudosysgen »

piva00 wrote: post #47
Alex3917 wrote: post #38

Earlier quoted context omitted.

Also women and smokers are underrepresented among hospitalized patients, which was the first confirmatory evidence from over a year ago.

I know nothing about physiology (apart from up to high school level, so... Nothing), could you expand on how smokers and women relate to ACE-2?

Nicotine upregulates ACE2 expression, but I don't know about women.

Re: SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2

#85

Post by podgaj »

nradov wrote: post #81
podgaj wrote: post #79

Earlier quoted context omitted.

Yeah yeah yeah, but why isn’t this been blasted with the public airwaves, especially in India? Plus, they’re giving zinc to people already sick. Why not check people for zinc deficiency and supply them with the zinc they need? I know why, it’s because we don’t believe in preventative care in this country.

Yes it is disappointing how public health authorities have focused almost entirely on exposure prevention. There should be equal focus on harm reduction for people who do get exposed.

The frustrating part is we know that some people are fine catching SARS2 and others die, yet the never want to compare the biology of these people. We have the largest data set ever of something that could lead to the prevention of illness yet they just want to treat everyone the same.

Re: SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2

#86

Post by unanswered »

molticrystal wrote: post #77
hourislate wrote: post #53

Earlier quoted context omitted.

Disclaimer: I am not qualified to interpret this study and have no experience in this field. So the study indicates that the Spike Protein binds to ACE2 that is found in the membranes of cells located in the lungs, arteries, heart, kidney, and intestines, and down regulates them to the point where it damages your mitochondria in those organs. So according to the research they did, it's not just the virus that can hur…

>is administered in a intramuscular area of the body (Shoulder Area), never able to live long enough (mRNA dies off quickly) to enter these areas where ACE2 is found (Heart, Lungs, Kidneys, etc) We know to where it typically tends to go now, "the muscle tissue at the site of injection, the lymphatic tissue downstream in your armpit on that side, your spleen, and (for the first day or two) your liver. " [0] [0] https:…

The funny thing is that list of places the mRNA gets to does not have any overlap with my list of "places in my body where I want SARS-CoV-2 spike protein".

Re: SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2

#87

Post by exPerTrust »

beagle3 wrote: post #62
maxerickson wrote: post #58

Earlier quoted context omitted.

There were animal studies: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449230/ I was just asking to understand your reasoning, I wasn't asking you to convince me it was correct, and I'm not trying to convince you it isn't correct.

Thank you, I failed to find this one in my previous literature search. I don't have it handy now, but for at least one SARS-Cov-1 vaccine candidate everything seemed fine, and good immediate antibody response (as in this paper), but another challenge 3 months later had an ADE response with worse outcomes than a naive infection. IIRC it was done in felines, not in primates.

Beagle don't let yourself convince so easily, you are still right, they didn't done long term studies in animals, thus its not wrong to say that they skipped long term efficacy or safety in animals. Meaning they skipped it. In who is being done the long term studies? Yes, that's what you thinking.. in humans. These should be done in animals first for years, but what have they done? They skipped it... If you read carefully the study lasted 8 weeks and 15 days only. Quote "At week 8 (4 weeks after the second vaccination), all animals were challenged with the wild virus)", then "lung sections from animals that were killed at day 14 or 15". So, only two months and 15 days max, then when the vaccine was authorized they jumped directly to humans.

While in this animal trial they only waited 4 weeks after the second vaccination and challenged, the challenge you mention that was done only 3 months later, this is a small example of a mini long term follow up. They havent done that at all.. They skipped it, just to do the follow up in.. humans, so yes humans are still being trialed with the vaccines. When the next wave comes in the winter, more than 3 months from today, 7 months ahead, in October, it will be a catastrophe caused by ADE.

Re: SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2

#88

Post by gdubs »

unanswered wrote: post #3

If this is a function of the spike protein, doesn't that mean the mRNA vaccines cause this effect as well?

Just this morning I was reading this paper [1] which is looking at the effects of the spike protein alone on pulmonary function - it’s a pretty straightforward read once you get beyond the acronyms:

https://www.mdpi.com/2076-393X/9/1/36/htm

Re: SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2

#89

Post by stjohnswarts »

treeman79 wrote: post #40
morsch wrote: post #4

"Endotheliitis is an immune response within the endothelium in blood vessels, in which they become inflamed. The condition can cause oedema of the surrounding tissue, including the stroma, and can cause irritation and pain. If it is within the cornea, it can result in permanent loss of vision. The condition can be caused by a number of factors, such as mumps and cytomegalovirus under certain circumstances." (Wikipedi…

My blood vessels get inflamed now and then. In Sjogrens world it’s known as a “flare” It’s horrifically painful. There is no sympathy from anyone since you look normal.

I had a friend with that. The flares could have her basically out of action for a month or more as she was IT and found it impossible to work during those times.

Re: SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2

#90

Post by stjohnswarts »

unanswered wrote: post #3

If this is a function of the spike protein, doesn't that mean the mRNA vaccines cause this effect as well?

Probably but it's not like they can increase exponentially in number. It's as much about the viral load as the viral type. It's not an on or off switch.
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