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What can mRNA treat next?

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Re: What can mRNA treat next?

#131

Post by parshua »

lazide wrote: post #100
DocTomoe wrote: post #90

Earlier quoted context omitted.

This honestly is highly concerning - if that can be done for species, the next step could be to target ethnicity. I feel like this is one of those Oppenheimeresque moments in human history.

It’s been tried and done before via chemical and biological methods (if you don’t want to sleep for awhile, check out what has been declassified on THOSE topics and realize that is what they were OK releasing to the public!). The problem of course is that in deploying it, you’ll inevitably kill a bunch of your own - no population is so consistent you won’t kill a bunch of senior leaders who had parents 3 generations…

Why do you bring Iran or NK into this? Let's get it straight: Until now, the only counties who have actually tried genocide on industrial scale, have performed inhumane tests on live subjects of other cultures or used Nukes on civilian targets have been mostly western. Heck, they were literally wiping each other out right until 75 years ago. They are also the ones actively ganging up and invading others TODAY. What delusion suddenly caused you to think it is again 'others' who are trying to wipe you out?

Re: What can mRNA treat next?

#132

Post by [deleted] »

r3pl4y wrote: post #126

#ExplainLikeImFive Could somebody explain to me what a PVC (Personalized Cancer Vaccine) is? Like what is the personalized part in there? Is there really a realistic scenario in which we'll get some regular vaccination and then we'll be cancer free in the future?

[deleted]

Re: What can mRNA treat next?

#133

Post by stefantalpalaru »

est31 wrote: post #64
ecedeno wrote: post #53

Moderna has a public development pipeline. It shows they are working on, among other things, an HIV vaccine and vaccines/therapies for multiple types of cancer. https://www.modernatx.com/pipeline

Plus a flu vaccine: > mRNA vaccines [...] generate a much stronger immune response than responses that are generated to the protein in a normal flu vaccine [...] > One limitation of the current flu vaccines is that they take about six months to develop, meaning scientists must choose which strains they think will be prevalent in the next flu season — even before the current one is over. So by the time the vaccines ar…

> mRNA vaccines [...] generate a much stronger immune response than responses that are generated to the protein in a normal flu vaccine [...]

That's probably due to the immunogenicity of those lipid nanoparticles used to encapsulate the mRNA (particularly the cationic lipid): https://www.biorxiv.org/content/10.1101/2021.03.04.430128v1....

Re: What can mRNA treat next?

#134

Post by lucb1e »

Because it's buried in some two thousand words:

> helping cells produce tissue to heal from events such as cardiac arrest

> beyond simple vaccines [...] mRNA therapeutics might be tailored to instruct a person’s immune system to fight their specific type of cancer, or target protein deficiencies in specific organs, and without the toxic side effects of traditional medications.

> “My personal moonshot is snake venom, and antivenoms for snake bites,” he says. [...] “You inject it into a person, and within hours the protein that you wish is being expressed,” he explains. The final product of such research, he imagines, would be an antidote that could work for the most lethal species of a specific area, delivered in a way that can be preserved for long times in very remote areas—for instance, a powder that can be stored for long periods of time and reconstituted quickly.

This is literally all the info I found that is actually relevant to the interesting headline. The rest of the article is about this person's career and what funding vaccine companies got in 2020.

Re: What can mRNA treat next?

#137

Post by throwaway879 »

throwaway879 wrote: post #129

Do the concerns raised here have any merit? https://osf.io/epr24/

Why would anyone down-vote a question asking if there is any merit to some concerns raised by a clinical researcher? The target audience is people working on mRNA vaccines who might be able to shed some light.

Re: What can mRNA treat next?

#138

Post by tecleandor »

da_big_ghey wrote: post #102
toast0 wrote: post #88

Earlier quoted context omitted.

Now that mRNA is productionized (or at least on the path towards it), and has been used in hundreds of millions of people without apparent major negative short term effects, the barrier is lower for other targets which no longer have to prove the whole technology is safe, effective, and producable. We have two examples of safe (so far), effective and mass produced mrna vaccines; so it's probably easier to get funding…

how much money in cure HIV? largest endemic area is probably subsaharan Africa, not much in money there. In western nation it mostly is disease for gays or ocasional unlucky blood transfusion receive person [0]. i am not say that cure for it is bad - it is in obvious good - why did Moderna make choice for to research this cure in specific over other? https://www.cdc.gov/nchhstp/newsroom/docs/factsheets/cdc-msm...

That's an answer right from the 80s and it's completely wrong and against the same statistics you link. In the US heterosexuals account for more than 25% of AIDS infections, not accounting bisexuals and undetermined infections.

Re: What can mRNA treat next?

#139

Post by dinkleberg »

da_big_ghey wrote: post #102
toast0 wrote: post #88

Earlier quoted context omitted.

Now that mRNA is productionized (or at least on the path towards it), and has been used in hundreds of millions of people without apparent major negative short term effects, the barrier is lower for other targets which no longer have to prove the whole technology is safe, effective, and producable. We have two examples of safe (so far), effective and mass produced mrna vaccines; so it's probably easier to get funding…

how much money in cure HIV? largest endemic area is probably subsaharan Africa, not much in money there. In western nation it mostly is disease for gays or ocasional unlucky blood transfusion receive person [0]. i am not say that cure for it is bad - it is in obvious good - why did Moderna make choice for to research this cure in specific over other? https://www.cdc.gov/nchhstp/newsroom/docs/factsheets/cdc-msm...

Do you ever read what you write before posting it and do a basic morality review?

I’m sure there are many valid points to debate which diseases to go after next, but you only consider the money. I’m a capitalist and love making money, but come on!

Questioning the choice to go after HIV because the primary people benefiting are too poor or gay? That is insanity.

Re: What can mRNA treat next?

#140

Post by roywiggins »

entee wrote: post #106
lisper wrote: post #73

Earlier quoted context omitted.

OK, but that doesn't really answer my question. Turns out the answer can be found here: https://www.cdc.gov/flu/about/viruses/types.htm "There are four types of influenza viruses: A, B, C and D. Human influenza A and B viruses cause seasonal epidemics of disease (known as the flu season) almost every winter in the United States. Influenza A viruses are the only influenza viruses known to cause flu pandemics, i.e., gl…

I don't think that's quite right. Even if you have a flu strain with a particular name (H1N1) there are a number of variants within the H1 and/or N1 proteins that the vaccine will be targeted to as well, so the number is quite a bit larger than 198/131. It's not that hard to make a new vaccine, the process for flu is very accelerated because they're just a variation on the original theme which has been proven to be s…

It would be especially worth it to have approved mRNA flu vaccine in hand for the next pandemic flu. You'd might be able to actually vaccinate your way out of it.
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