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What can mRNA treat next?

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Re: What can mRNA treat next?

#51

Post by CorrectHorseBat »

ProjectArcturis wrote: post #35

There are a lot of folks excited about mRNA as a "programming language" for the body. And it kind of is, but it's more complicated than that. The critical thing is that mRNA is extremely immunogenic -- that is, it provokes a strong immune response. Makes sense, since evolutionarily when we had little particles delivering RNA strands to our cells, they we viruses. So, that's great for vaccine production. Not so great…

I thought they solved that by replacing U by 1-methyl-3'-pseudouridylyl in mRNA vaccines? I can imagine it's not great for vaccines either, you want the immune system attack the spike the mRNA codes for, not destroy the mRNA before it can do it's thing.

https://berthub.eu/articles/posts/reverse-engineering-source...

Re: What can mRNA treat next?

#52

Post by ratsbane »

dukeofdoom wrote: post #11

hair loss?

I think that DNA methylation is a big factor in hair loss as well as hair color changes. There are other disease processes which are also driven by DNA/RNA methylation, so a treatment for any of these might also lead to treatments for all of them. (And I don't really know what I'm talking about and I hope someone with more expertise can add to this)

Re: What can mRNA treat next?

#54

Post by cigaser »

Well, it will treat everything. Soon it will be generic technology, accessible to any low-tier lab with "RNA printer". Any country will be able to download medication from internet. And in most places it is impossible to copyright naturally occurring RNA sequence.

Re: What can mRNA treat next?

#55

Post by cigaser »

intricatedetail wrote: post #4

I would love that the state sponsored research into chronic pain. Big pharma has no incentive to find cure, they want to push a suite of addictive pills that ruin lives or they spend money to block medical cannabis. Millions of people suffer with no way out. Edit: why people downvote the truth? I guess none of you suffered this and I hope you will not, but silencing a voice like that is inhumane.

Chronic pain is just a symptom. There could be million causes that needs to be treated first. And cannabis is just another form of "addictive pill", no better than opioids.

Re: What can mRNA treat next?

#56

Post by unnouinceput »

simcop2387 wrote: post #45
im3w1l wrote: post #39

Earlier quoted context omitted.

What about hiv?

HIV is a virus, so it would seem to be a good candidate for mRNA since you'd want to make it generate an aggressive and early response to the virus. I can't even guess though what challenges would arise given that HIV likes to target the immune system itself.

This might shed some light:

https://www.businessinsider.com/new-hiv-vaccine-could-be-mod...

Re: What can mRNA treat next?

#57

Post by subpixel »

Tick-borne diseases are not all similar but many of them are very, very nasty and Lyme Disease is not the worst of them.

I’d love for my kids to be able to play in the weeds and woods with abandon the way I did.

Re: What can mRNA treat next?

#58

Post by perardi »

intricatedetail wrote: post #4

I would love that the state sponsored research into chronic pain. Big pharma has no incentive to find cure, they want to push a suite of addictive pills that ruin lives or they spend money to block medical cannabis. Millions of people suffer with no way out. Edit: why people downvote the truth? I guess none of you suffered this and I hope you will not, but silencing a voice like that is inhumane.

Well…there is state sponsorship, via the NIH.

https://www.nccih.nih.gov/nih-pain-research-center/research-...

“Pain” is almost never the disease. (OK, maybe CRPS.) There’s a lot of things that cause pain, almost self-evidently, so it’s not one particular thing to attack, unlike a virus.

(Also we are at 36 states now with medical marijuana, so I think the “pharma wants to block this” ship has sailed, especially when you consider big-hitters like California and New York have full recreational marijuana now.)

Re: What can mRNA treat next?

#60

Post by fuckyah »

ProjectArcturis wrote: post #35

There are a lot of folks excited about mRNA as a "programming language" for the body. And it kind of is, but it's more complicated than that. The critical thing is that mRNA is extremely immunogenic -- that is, it provokes a strong immune response. Makes sense, since evolutionarily when we had little particles delivering RNA strands to our cells, they we viruses. So, that's great for vaccine production. Not so great…

I wouldnt jump to conclusions, as we haven't seen the real impact of the vaccines yet. We still don't know if they actually prevent all-cause deaths. We also don't know anything about long term side effects.
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