SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2
1–10 of 100 posts
Re: SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2
#2Link to full PDF: https://www.biorxiv.org/content/biorxiv/early/2020/12/04/202...
Re: SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2
#3If this is a function of the spike protein, doesn't that mean the mRNA vaccines cause this effect as well?
Re: SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2
#4"Endotheliitis is an immune response within the endothelium in blood vessels, in which they become inflamed. The condition can cause oedema of the surrounding tissue, including the stroma, and can cause irritation and pain. If it is within the cornea, it can result in permanent loss of vision. The condition can be caused by a number of factors, such as mumps and cytomegalovirus under certain circumstances." (Wikipedia)
And, as to the first question that came to my mind, from the paper: "Collectively, our results suggest that the S protein-exerted EC damage overrides the decreased virus infectivity. This conclusion suggests that vaccination-generated antibody and/or exogenous antibody against S protein not only protects the host from SARS-CoV-2 infectivity but also inhibits S protein-imposed endothelial injury and ultimately decrease cardiovascular complication-associated mortality in COVID-19 patients."
Re: SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2
#5Yeah we've known this for over 10 years, zero surprise here. There were literally popular books written saying that this would be the mechanism of action for novel coronavirus pandemics (and how to treat them) years before the current pandemic even started, e.g.:
https://www.amazon.com/Herbal-Antivirals-Remedies-Resistant-...
Here is the direct quote from the book, published in 2013:
"Once receptors on these cells are compromised there is enhanced vascular permeability, increased lung edema, neutrophil accumulation, and worsened lung function. In essence, once the virus begins attaching to ACE-2, ACE-2 function begins to be destroyed. ACE-2 function also tends to be less dynamic as people grow older, hence the more negative the effects of SARS infection on the elderly. [...] ACE (in contrast with ACE-2) inhibitors increase the presence of ACE-2 and help protect the lungs from injury."
Re: SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2
#6If this is a function of the spike protein, doesn't that mean the mRNA vaccines cause this effect as well?
The spike protein from the virus bands to ACE2 receptor, messing them up. The vaccine primes our bodies to attack the spike protein, preventing it from binding to ACE2 and thus preventing it from messing up ACE2 receptors.
Re: SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2
#7Yeah we've known this for over 10 years, zero surprise here. There were literally popular books written saying that this would be the mechanism of action for novel coronavirus pandemics (and how to treat them) years before the current pandemic even started, e.g.: https://www.amazon.com/Herbal-Antivirals-Remedies-Resistant-... Here is the direct quote from the book, published in 2013: "Once receptors on these cells ar…
Yes, that's why they went looking to verify that hypothesis and lay out the mechanism that the virus acts...
Re: SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2
#8If this is a function of the spike protein, doesn't that mean the mRNA vaccines cause this effect as well?
The spike protein from the virus bands to ACE2 receptor, messing them up. The vaccine primes our bodies to attack the spike protein, preventing it from binding to ACE2 and thus preventing it from messing up ACE2 receptors.
But the vaccine causes the body to produce spike protein. The CDC emphasizes the spike protein is harmless, but this new research finds that the spike protein itself can cause damage.
https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different...
Re: SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2
#9If this is a function of the spike protein, doesn't that mean the mRNA vaccines cause this effect as well?
this is a relevent question, the difference between the two cases, is that the virus is mobile and has opportunity to travel through the entire endothelial tissue structure, interacting with many molecular types and situations
the vaccine causes a small volume of stationary cells in the muscle mass of the shoulder to express the S protien on the surface, staying in place but providing signal to the immune system
[adndm] keep in mind the virus replicates, inside you, the vaccine doesnt, and the vaccine stays where you put it, it doesnt spread out everywhere that has a receptor
Re: SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2
#10Earlier quoted context omitted.
The spike protein from the virus bands to ACE2 receptor, messing them up. The vaccine primes our bodies to attack the spike protein, preventing it from binding to ACE2 and thus preventing it from messing up ACE2 receptors.
But the vaccine causes the body to produce spike protein. The CDC emphasizes the spike protein is harmless, but this new research finds that the spike protein itself can cause damage. https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different...
This has been the clever guy hot take for a few days now. Yet millions of people are walking around vaccinated without damage, so....