What can mRNA treat next?
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Re: What can mRNA treat next?
#2I am so excited for the prospect of mRNA treatments, especially in the field of auto immune conditions like multiple sclerosis. Those scientists are heroes.
Re: What can mRNA treat next?
#3Hopefully my height. Hello, 6 feet.
Re: What can mRNA treat next?
#4I would love that the state sponsored research into chronic pain. Big pharma has no incentive to find cure, they want to push a suite of addictive pills that ruin lives or they spend money to block medical cannabis. Millions of people suffer with no way out.
Edit: why people downvote the truth? I guess none of you suffered this and I hope you will not, but silencing a voice like that is inhumane.
Re: What can mRNA treat next?
#5I am so excited for the prospect of mRNA treatments, especially in the field of auto immune conditions like multiple sclerosis. Those scientists are heroes.
If that's possible, curing type 1 diabetes would be on the horizon as well. There's some evidence that people with t1d have latent beta cells that could be reactivated to restore normal(ish?) insulin response. That would be incredible.
Re: What can mRNA treat next?
#6I am so excited for the prospect of mRNA treatments, especially in the field of auto immune conditions like multiple sclerosis. Those scientists are heroes.
Are there any online resources where I could learn more about what mRNA treatments could theoretically cure? Take Hashimoto's disease for example, a disease where your thyroid gland slowly gets destroyed by your immune system. If I understand correctly, mRNA could stop your thyroid gland from getting destroyed in the first place, but it cannot regenerate the thyroid gland if it has already been destroyed. Is that correct?
Re: What can mRNA treat next?
#7It's an indictment of something that we've had this amazing new tool for vaccine production in existence for a decade but we never even tried to use it for that until COVID because "vaccines typically don’t make much money" and "vaccines just aren’t that exciting" scientifically: "it’s nice and easy," to quote Rossi from the article.
If it really does turn out that effective mRNA vaccines can be created in a straightforward way for a host of new diseases, that's ten years of deaths and misery that we as a society just allowed to happen unnecessarily. I don't know how to fix that: maybe the market-based incentive structures that work for acute disease treatments aren't a good fit for broad preventative public health measures like vaccines.
Re: What can mRNA treat next?
#8Hopefully my height. Hello, 6 feet.
Probably a niche application. Most persons want exactly two.
Re: What can mRNA treat next?
#9Many cancers exhibit immunosuppressive qualities that allow them to co-exist in a healthy immune system. It seems possible that mRNA-based therapies could be used to interfere with those mechanisms (eg binding to PD-L1, etc).
The delivery mechanism for the mRNA appears to be the primary innovation and I wonder if it would be possible to target it at specific cells. In the cancer context if you could differentially target the mRNA delivery to cancerous tissue, the 'payload' could be more generally cytotoxic but only affect tissue proximate to cancer cells.
This seems like it's on the order of CRISPR for potential to change the landscape of medicine in the next 50 years.
Re: What can mRNA treat next?
#10I would love that the state sponsored research into chronic pain. Big pharma has no incentive to find cure, they want to push a suite of addictive pills that ruin lives or they spend money to block medical cannabis. Millions of people suffer with no way out. Edit: why people downvote the truth? I guess none of you suffered this and I hope you will not, but silencing a voice like that is inhumane.
I didn't downvote, but if I had to guess, I suspect it's because your comment seems to have very little to do with the article (apart from the fact that the article is about medical research and you are advocating for a different sort of medical research). If there's a specific reason to think that mRNA could be used in treating chronic pain, including that could make your comment more obviously on-topic. (Not that your underlying point is a bad one! It's just hard to see how it fits in a discussion of this particular article.)